(Q51025659)

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p62/SQSTM1 differentially removes the toxic mutant androgen receptor via autophagy and inclusion formation in a spinal and bulbar muscular atrophy mouse model.

scientific article published in May 2013

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29 February 2020

p62/SQSTM1 differentially removes the toxic mutant androgen receptor via autophagy and inclusion formation in a spinal and bulbar muscular atrophy mouse model (English)

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29 February 2020

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muscular atrophy

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29 February 2020

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Hideki Doi

1

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29 February 2020

Masahisa Katsuno

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29 February 2020

Makoto Minamiyama

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29 February 2020

Shinjiro Matsumoto

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29 February 2020

Naohide Kondo

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29 February 2020

Yu Miyazaki

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29 February 2020

Madoka Iida

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29 February 2020

Genki Tohnai

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29 February 2020

Qiang Qiang

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29 February 2020

Fumiaki Tanaka

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29 February 2020

Toru Yanagawa

12

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29 February 2020

Eiji Warabi

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29 February 2020

Tetsuro Ishii

14

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29 February 2020

Gen Sobue

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29 February 2020

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1 May 2013

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29 February 2020

Journal of Neuroscience

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29 February 2020

33

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29 February 2020

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29 February 2020

7710-7727

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29 February 2020

Transgenic mice with an expanded CAG repeat controlled by the human AR promoter show polyglutamine nuclear inclusions and neuronal dysfunction without neuronal cell death

1 reference

https://pubmed.ncbi.nlm.nih.gov/23637164

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ubiquitin-binding protein p62 is present in neuronal and glial inclusions in human tauopathies and synucleinopathies

1 reference

https://pubmed.ncbi.nlm.nih.gov/23637164

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Molecular chaperones enhance the degradation of expanded polyglutamine repeat androgen receptor in a cellular model of spinal and bulbar muscular atrophy

1 reference

https://pubmed.ncbi.nlm.nih.gov/23637164

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A long CAG repeat in the mouse Sca1 locus replicates SCA1 features and reveals the impact of protein solubility on selective neurodegeneration.

1 reference

https://pubmed.ncbi.nlm.nih.gov/23637164

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Altered transcriptional regulation in cells expressing the expanded polyglutamine androgen receptor

1 reference

https://pubmed.ncbi.nlm.nih.gov/23637164

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Testosterone reduction prevents phenotypic expression in a transgenic mouse model of spinal and bulbar muscular atrophy

1 reference

https://pubmed.ncbi.nlm.nih.gov/23637164

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ligand promotes intranuclear inclusions in a novel cell model of spinal and bulbar muscular atrophy

1 reference

https://pubmed.ncbi.nlm.nih.gov/23637164

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

SCA7 knockin mice model human SCA7 and reveal gradual accumulation of mutant ataxin-7 in neurons and abnormalities in short-term plasticity.

1 reference

https://pubmed.ncbi.nlm.nih.gov/23637164

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Leuprorelin rescues polyglutamine-dependent phenotypes in a transgenic mouse model of spinal and bulbar muscular atrophy

1 reference

https://pubmed.ncbi.nlm.nih.gov/23637164

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Interaction codes within the family of mammalian Phox and Bem1p domain-containing proteins

1 reference

https://pubmed.ncbi.nlm.nih.gov/23637164

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Two novel mutations at exon 8 of the Sequestosome 1 (SQSTM1) gene in an Italian series of patients affected by Paget's disease of bone (PDB).

1 reference

https://pubmed.ncbi.nlm.nih.gov/23637164

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inclusion body formation reduces levels of mutant huntingtin and the risk of neuronal death

1 reference

https://pubmed.ncbi.nlm.nih.gov/23637164

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Widespread nuclear and cytoplasmic accumulation of mutant androgen receptor in SBMA patients

1 reference

https://pubmed.ncbi.nlm.nih.gov/23637164

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neuronal dysfunction in a polyglutamine disease model occurs in the absence of ubiquitin-proteasome system impairment and inversely correlates with the degree of nuclear inclusion formation

1 reference

https://pubmed.ncbi.nlm.nih.gov/23637164

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

17-AAG, an Hsp90 inhibitor, ameliorates polyglutamine-mediated motor neuron degeneration

1 reference

https://pubmed.ncbi.nlm.nih.gov/23637164

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Therapeutics development for triplet repeat expansion diseases

1 reference

https://pubmed.ncbi.nlm.nih.gov/23637164

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

p62/SQSTM1 forms protein aggregates degraded by autophagy and has a protective effect on huntingtin-induced cell death

1 reference

https://pubmed.ncbi.nlm.nih.gov/23637164

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

BIOMEDICINE: One Misfolded Protein Allows Others to Sneak By.

1 reference

https://pubmed.ncbi.nlm.nih.gov/23637164

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Efficient selection for high-expression transfectants with a novel eukaryotic vector

1 reference

https://pubmed.ncbi.nlm.nih.gov/23637164

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

p62 accumulates and enhances aggregate formation in model systems of familial amyotrophic lateral sclerosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/23637164

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pathogenesis and molecular targeted therapy of spinal and bulbar muscular atrophy.

1 reference

https://pubmed.ncbi.nlm.nih.gov/23637164

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A toxic monomeric conformer of the polyglutamine protein

1 reference

https://pubmed.ncbi.nlm.nih.gov/23637164

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

p62/SQSTM1 binds directly to Atg8/LC3 to facilitate degradation of ubiquitinated protein aggregates by autophagy

1 reference

https://pubmed.ncbi.nlm.nih.gov/23637164

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Use of p62/SQSTM1 antibodies for neuropathological diagnosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/23637164

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Homeostatic levels of p62 control cytoplasmic inclusion body formation in autophagy-deficient mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/23637164

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Structural basis for sorting mechanism of p62 in selective autophagy

1 reference

https://pubmed.ncbi.nlm.nih.gov/23637164

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

17-DMAG ameliorates polyglutamine-mediated motor neuron degeneration through well-preserved proteasome function in an SBMA model mouse

1 reference

https://pubmed.ncbi.nlm.nih.gov/23637164

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Autophagy inhibition compromises degradation of ubiquitin-proteasome pathway substrates.

1 reference

https://pubmed.ncbi.nlm.nih.gov/23637164

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cytoplasmic retention of polyglutamine-expanded androgen receptor ameliorates disease via autophagy in a mouse model of spinal and bulbar muscular atrophy

1 reference

https://pubmed.ncbi.nlm.nih.gov/23637164

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Molecular pathogenesis of protein misfolding diseases: pathological molecular environments versus quality control systems against misfolded proteins

1 reference

https://pubmed.ncbi.nlm.nih.gov/23637164

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The pathogenic mechanisms of polyglutamine diseases and current therapeutic strategies

1 reference

https://pubmed.ncbi.nlm.nih.gov/23637164

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Overexpression of IGF-1 in muscle attenuates disease in a mouse model of spinal and bulbar muscular atrophy

1 reference

https://pubmed.ncbi.nlm.nih.gov/23637164

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identical oligomeric and fibrillar structures captured from the brains of R6/2 and knock-in mouse models of Huntington's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/23637164

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Heat shock proteins in neurodegenerative diseases: pathogenic roles and therapeutic implications

1 reference

https://pubmed.ncbi.nlm.nih.gov/23637164

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

PINK1/Parkin-mediated mitophagy is dependent on VDAC1 and p62/SQSTM1

1 reference

https://pubmed.ncbi.nlm.nih.gov/23637164

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Methods in mammalian autophagy research

1 reference

https://pubmed.ncbi.nlm.nih.gov/23637164

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neurotoxic protein oligomerisation associated with polyglutamine diseases

1 reference

https://pubmed.ncbi.nlm.nih.gov/23637164

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Efficacy and safety of leuprorelin in patients with spinal and bulbar muscular atrophy (JASMITT study): a multicentre, randomised, double-blind, placebo-controlled trial

1 reference

https://pubmed.ncbi.nlm.nih.gov/23637164

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Selective degradation of p62 by autophagy

1 reference

https://pubmed.ncbi.nlm.nih.gov/23637164

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

An Interdomain Interaction of the Androgen Receptor Is Required for Its Aggregation and Toxicity in Spinal and Bulbar Muscular Atrophy

1 reference

https://pubmed.ncbi.nlm.nih.gov/23637164

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Protein quality control in the cytosol and the endoplasmic reticulum: brothers in arms.

1 reference

https://pubmed.ncbi.nlm.nih.gov/23637164

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ubiquitinated, p62 immunopositive cerebellar cortical neuronal inclusions are evident across the spectrum of TDP-43 proteinopathies but are only rarely additionally immunopositive for phosphorylation-dependent TDP-43

1 reference

https://pubmed.ncbi.nlm.nih.gov/23637164

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Selective autophagy mediated by autophagic adapter proteins

1 reference

https://pubmed.ncbi.nlm.nih.gov/23637164

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Efficacy and safety of dutasteride in patients with spinal and bulbar muscular atrophy: a randomised placebo-controlled trial.

1 reference

https://pubmed.ncbi.nlm.nih.gov/23637164

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

p62 Targeting to the autophagosome formation site requires self-oligomerization but not LC3 binding

1 reference

https://pubmed.ncbi.nlm.nih.gov/23637164

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Altered chromatin architecture underlies progressive impairment of the heat shock response in mouse models of Huntington disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/23637164

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Serine 403 phosphorylation of p62/SQSTM1 regulates selective autophagic clearance of ubiquitinated proteins

1 reference

https://pubmed.ncbi.nlm.nih.gov/23637164

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Autophagy: renovation of cells and tissues

1 reference

https://pubmed.ncbi.nlm.nih.gov/23637164

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

p62 positive, TDP-43 negative, neuronal cytoplasmic and intranuclear inclusions in the cerebellum and hippocampus define the pathology of C9orf72-linked FTLD and MND/ALS

1 reference

https://pubmed.ncbi.nlm.nih.gov/23637164

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

SIRT1 modulates aggregation and toxicity through deacetylation of the androgen receptor in cell models of SBMA.

1 reference

https://pubmed.ncbi.nlm.nih.gov/23637164

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

An MND/ALS phenotype associated with C9orf72 repeat expansion: abundant p62-positive, TDP-43-negative inclusions in cerebral cortex, hippocampus and cerebellum but without associated cognitive decline.

1 reference

https://pubmed.ncbi.nlm.nih.gov/23637164

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Suppression of protein aggregation by chaperone modification of high molecular weight complexes

1 reference

https://pubmed.ncbi.nlm.nih.gov/23637164

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Viral delivery of miR-196a ameliorates the SBMA phenotype via the silencing of CELF2

1 reference

https://pubmed.ncbi.nlm.nih.gov/23637164

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

X-linked recessive bulbospinal neuronopathy. A clinicopathological study

1 reference

https://pubmed.ncbi.nlm.nih.gov/23637164

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Nuclear inclusions of the androgen receptor protein in spinal and bulbar muscular atrophy

1 reference

https://pubmed.ncbi.nlm.nih.gov/23637164

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ataxin-1 nuclear localization and aggregation: role in polyglutamine-induced disease in SCA1 transgenic mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/23637164

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Huntingtin acts in the nucleus to induce apoptosis but death does not correlate with the formation of intranuclear inclusions.

1 reference

https://pubmed.ncbi.nlm.nih.gov/23637164

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1523/JNEUROSCI.3021-12.2013

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Europe PubMed Central

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29 February 2020

PMC publication ID

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23637164%20AND%20SRC:MED&resulttype=core&format=json

29 February 2020

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23637164%20AND%20SRC:MED&resulttype=core&format=json

29 February 2020

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