(Q51043312)

27 March 2018

title

Sustained T cell Rap1 signaling is protective in the collagen-induced arthritis model of rheumatoid arthritis. (English)

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Aleksander M. Grabiec

4

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Martijn A. Nolte

6

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Paul P Tak

7

object named as

Paul P Tak

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author name string

Joana R F Abreu

1

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Sarah Krausz

2

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Wendy Dontje

3

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Daphne de Launay

5

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Kris A Reedquist

8

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publication date

1 November 2010

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published in

Arthritis & Rheumatology

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volume

62

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issue

11

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page(s)

3289-3299

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Cells of the synovium in rheumatoid arthritis. T lymphocytes.

cites work

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TCRzetadim lymphocytes define populations of circulating effector cells that migrate to inflamed tissues

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Rap1 signaling is required for suppression of Ras-generated reactive oxygen species and protection against oxidative stress in T lymphocytes

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CD28 and the tyrosine kinase lck stimulate mitogen-activated protein kinase activity in T cells via inhibition of the small G protein Rap1.

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Rap1a null mice have altered myeloid cell functions suggesting distinct roles for the closely related Rap1a and 1b proteins

21 January 2018

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Rap1A positively regulates T cells via integrin activation rather than inhibiting lymphocyte signaling

21 January 2018

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Treatment with recombinant interferon-beta reduces inflammation and slows cartilage destruction in the collagen-induced arthritis model of rheumatoid arthritis

21 January 2018

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Rap-specific GTPase activating protein follows an alternative mechanism

21 January 2018

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High avidity autoreactive T cells with a low signalling capacity through the T-cell receptor: central to rheumatoid arthritis pathogenesis?

21 January 2018

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Effect of redox balance alterations on cellular localization of LAT and downstream T-cell receptor signaling pathways

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21 January 2018

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Inducible costimulator is essential for collagen-induced arthritis

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Functional CD40 ligand is expressed by T cells in rheumatoid arthritis

21 January 2018

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Rap1 functions as a key regulator of T-cell and antigen-presenting cell interactions and modulates T-cell responses

21 January 2018

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21 January 2018

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21 January 2018

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CD40 engagement on synovial fibroblast up-regulates production of vascular endothelial growth factor

21 January 2018

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21 January 2018

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Evidence that rheumatoid arthritis synovial T cells are similar to cytokine-activated T cells: involvement of phosphatidylinositol 3-kinase and nuclear factor kappaB pathways in tumor necrosis factor alpha production in rheumatoid arthritis

21 January 2018

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Efficacy and safety of the selective co-stimulation modulator abatacept following 2 years of treatment in patients with rheumatoid arthritis and an inadequate response to anti-tumour necrosis factor therapy

21 January 2018

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CTLA-4IG suppresses reactive oxygen species by preventing synovial adherent cell-induced inactivation of Rap1, a Ras family GTPASE mediator of oxidative stress in rheumatoid arthritis T cells

21 January 2018

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21 January 2018

Identifiers

DOI

10.1002/ART.27656

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27 March 2018

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