(Q51052754)

27 March 2018

title

Induction of autoimmune diabetes in non-obese diabetic mice requires interleukin-21-dependent activation of autoreactive CD8⁺ T cells. (English)

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27 March 2018

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X-L Chen

1

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27 March 2018

D Bobbala

2

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27 March 2018

G M Rodriguez

3

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M Mayhue

4

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27 March 2018

Y-G Chen

5

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27 March 2018

S Ilangumaran

6

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27 March 2018

S Ramanathan

7

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27 March 2018

publication date

1 August 2013

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27 March 2018

Clinical and Experimental Immunology

published in

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27 March 2018

volume

173

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27 March 2018

issue

2

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page(s)

184-194

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27 March 2018

Interleukin-2 gene variation impairs regulatory T cell function and causes autoimmunity

cites work

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Homeostatic expansion of T cells during immune insufficiency generates autoimmunity.

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IL-2 and its high-affinity receptor: genetic control of immunoregulation and autoimmunity.

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Resistance alleles at two non-major histocompatibility complex-linked insulin-dependent diabetes loci on chromosome 3, Idd3 and Idd10, protect nonobese diabetic mice from diabetes

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Loss of parity between IL-2 and IL-21 in the NOD Idd3 locus

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IL-21 signaling is critical for the development of type I diabetes in the NOD mouse

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Interleukin-21 is required for the development of type 1 diabetes in NOD mice

21 January 2018

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Interleukin-21 is critically required in autoimmune and allogeneic responses to islet tissue in murine models.

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Interleukin-21 receptor-mediated signals control autoreactive T cell infiltration in pancreatic islets

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A fundamental role for interleukin-21 in the generation of T follicular helper cells

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Essential autocrine regulation by IL-21 in the generation of inflammatory T cells

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Interleukin-21: Basic Biology and Implications for Cancer and Autoimmunity

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IL-21 and TGF-beta are required for differentiation of human T(H)17 cells

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Th17 cell differentiation: the long and winding road

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Regulation of gut inflammation and th17 cell response by interleukin-21.

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A critical role for IL-21 receptor signaling in the pathogenesis of systemic lupus erythematosus in BXSB-Yaa mice

21 January 2018

1 reference

Inflammatory tendencies and overproduction of IL-17 in the colon of young NOD mice are counteracted with diet change

21 January 2018

1 reference

Adjuvant treatment suppresses IL-17 production by T cell-independent myeloid sources in nonobese diabetic mice.

21 January 2018

1 reference

Interleukin-17-producing gammadelta+ T cells protect NOD mice from type 1 diabetes through a mechanism involving transforming growth factor-beta

21 January 2018

1 reference

Inhibition of type 1 diabetes correlated to a Lactobacillus johnsonii N6.2-mediated Th17 bias.

21 January 2018

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Th17 polarized cells from nonobese diabetic mice following mycobacterial adjuvant immunotherapy delay type 1 diabetes.

21 January 2018

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CD8+ T cells in autoimmunity

21 January 2018

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IL-21R on T cells is critical for sustained functionality and control of chronic viral infection

21 January 2018

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A vital role for interleukin-21 in the control of a chronic viral infection

21 January 2018

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IL-21 is required to control chronic viral infection

21 January 2018

1 reference

Critical role for IL-21 in both primary and memory anti-viral CD8+ T-cell responses

21 January 2018

1 reference

IL-21 deficiency influences CD8 T cell quality and recall responses following an acute viral infection

21 January 2018

1 reference

Exposure to IL-15 and IL-21 enables autoreactive CD8 T cells to respond to weak antigens and cause disease in a mouse model of autoimmune diabetes.

21 January 2018

1 reference

Spontaneous autoimmune diabetes in monoclonal T cell nonobese diabetic mice

21 January 2018

1 reference

IL-6, in synergy with IL-7 or IL-15, stimulates TCR-independent proliferation and functional differentiation of CD8+ T lymphocytes

21 January 2018

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Suppressor of cytokine signaling 1 stringently regulates distinct functions of IL-7 and IL-15 in vivo during T lymphocyte development and homeostasis.

21 January 2018

1 reference

Identification of the beta cell antigen targeted by a prevalent population of pathogenic CD8+ T cells in autoimmune diabetes.

21 January 2018

1 reference

Prediction of spontaneous autoimmune diabetes in NOD mice by quantification of autoreactive T cells in peripheral blood

21 January 2018

1 reference

Frontline: An in-depth evaluation of the production of IL-2 by antigen-specific CD8 T cells in vivo

21 January 2018

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Interleukin-2 signals during priming are required for secondary expansion of CD8+ memory T cells.

21 January 2018

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Il2 transcription unleashed by active DNA demethylation.

21 January 2018

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Recent developments in the transcriptional regulation of cytolytic effector cells

21 January 2018

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DNA methylation and the expanding epigenetics of T cell lineage commitment

21 January 2018

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Epigenetic remodeling of the IL-2 and IFN-gamma loci in memory CD8 T cells is influenced by CD4 T cells.

21 January 2018

1 reference

Immunology. A chronic need for IL-21

21 January 2018

1 reference

Endogenous IL-21 restricts CD8+ T cell expansion and is not required for tumor immunity.

21 January 2018

1 reference

IL-21 can supplement suboptimal Lck-independent MAPK activation in a STAT-3-dependent manner in human CD8(+) T cells

21 January 2018

1 reference

STAT5-mediated signals sustain a TCR-initiated gene expression program toward differentiation of CD8 T cell effectors

21 January 2018

1 reference

Interleukin-15 plays an essential role in the pathogenesis of autoimmune diabetes in the NOD mouse.

21 January 2018

1 reference

Interleukin-21 and the IL-21 receptor: novel effectors of NK and T cell responses

21 January 2018

1 reference

PubMed Central

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3722919

SNPs upstream of the minimal promoter control IL-2 expression and are candidates for the autoimmune disease-susceptibility locus Aod2/Idd3/Eae3

4 October 2018

1 reference

IL-2 gets with the program

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/23607664

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

A Functional Role for Interleukin-21 in Promoting the Synthesis of the T-Cell Chemoattractant, MIP-3α, by Gut Epithelial Cells

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/23607664

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

A Subset of Interleukin-21+ Chemokine Receptor CCR9+ T Helper Cells Target Accessory Organs of the Digestive System in Autoimmunity

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/23607664

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1111/CEI.12108

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27 March 2018

0 references

1 reference

27 March 2018