(Q51157184)

31 March 2018

title

Engineering human cytochrome P450 enzymes into catalytically self-sufficient chimeras using molecular Lego. (English)

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31 March 2018

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3

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31 March 2018

author name string

Vikash Rajnikant Dodhia

series ordinal

1

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31 March 2018

Andrea Fantuzzi

series ordinal

2

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31 March 2018

publication date

22 July 2006

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31 March 2018

Journal of Biological Inorganic Chemistry

published in

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31 March 2018

volume

11

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31 March 2018

issue

7

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31 March 2018

page(s)

903-916

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31 March 2018

Analysis of the structural stability of the multidomain enzyme flavocytochrome P-450 BM3

cites work

1 reference

Crossref

https://api.crossref.org/works/10.1007%2FS00775-006-0144-3

Expression, purification, and characterization of a catalytically active human cytochrome P450 1A2:rat NADPH-cytochrome P450 reductase fusion protein.

21 January 2018

1 reference

12 December 2020

Different contributions of cytochrome P450 2C19 and 3A4 in the oxidation of omeprazole by human liver microsomes: effects of contents of these two forms in individual human samples

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12 December 2020

High-level expression in Escherichia coli of enzymatically active fusion proteins containing the domains of mammalian cytochromes P450 and NADPH-P450 reductase flavoprotein

1 reference

12 December 2020

The many roles of cytochrome b5

1 reference

12 December 2020

Identification of residues 99, 220, and 221 of human cytochrome P450 2C19 as key determinants of omeprazole activity

1 reference

12 December 2020

Catalytic activities of human liver cytochrome P-450 IIIA4 expressed in Saccharomyces cerevisiae

1 reference

12 December 2020

Association of cytochromes P450 with their reductases: opposite sign of the electrostatic interactions in P450BM-3 as compared with the microsomal 2B4 system

1 reference

12 December 2020

Engineering proteins, subcloning and hyperexpressing oxidoreductase genes

1 reference

12 December 2020

Amino acid 305 determines catalytic center accessibility in CYP3A4.

1 reference

12 December 2020

The effects of cytochrome b5, NADPH-P450 reductase, and lipid on the rate of 6 beta-hydroxylation of testosterone as catalyzed by a human P450 3A4 fusion protein

1 reference

12 December 2020

Activation of cytochrome P450 2C9-mediated metabolism: mechanistic evidence in support of kinetic observations

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12 December 2020

Validated assays for human cytochrome P450 activities

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12 December 2020

Arginines 97 and 108 in CYP2C9 are important determinants of the catalytic function

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12 December 2020

Evidence for conformational dynamics and molecular aggregation in cytochrome P450 102 (BM-3)

1 reference

12 December 2020

CYP3A4 active site volume modification by mutagenesis of leucine 211.

1 reference

12 December 2020

Probing electron transfer in flavocytochrome P-450 BM3 and its component domains.

1 reference

12 December 2020

The structure of human microsomal cytochrome P450 3A4 determined by X-ray crystallography to 2.05-A resolution

1 reference

12 December 2020

Substrate selectivity of human cytochrome P450 2C9: importance of residues 476, 365, and 114 in recognition of diclofenac and sulfaphenazole and in mechanism-based inactivation by tienilic acid

1 reference

12 December 2020

Purification and enzymatic properties of a recombinant fusion protein expressed in Escherichia coli containing the domains of bovine P450 17A and rat NADPH-P450 reductase.

1 reference

12 December 2020

THE CARBON MONOXIDE-BINDING PIGMENT OF LIVER MICROSOMES. I. EVIDENCE FOR ITS HEMOPROTEIN NATURE

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12 December 2020

Role of conserved Asp293 of cytochrome P450 2C9 in substrate recognition and catalytic activity.

1 reference

12 December 2020

Human cytochrome P450s: selectivity and measurement in vivo

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12 December 2020

Functional characterisation of an engineered multidomain human P450 2E1 by molecular Lego.

1 reference

12 December 2020

The catalytic pathway of cytochrome p450cam at atomic resolution

1 reference

12 December 2020

DICHROWEB: an interactive website for the analysis of protein secondary structure from circular dichroism spectra.

1 reference

12 December 2020

A universal approach to the expression of human and rabbit cytochrome P450s of the 2C subfamily in Escherichia coli

1 reference

12 December 2020

Differential roles of Arg97, Asp293, and Arg108 in enzyme stability and substrate specificity of CYP2C9.

1 reference

12 December 2020

Mutagenesis study of Asp-290 in cytochrome P450 2B11 using a fusion protein with rat NADPH-cytochrome P450 reductase.

1 reference

12 December 2020

Human cytochrome P450 3A4: enzymatic properties of a purified recombinant fusion protein containing NADPH-P450 reductase

1 reference

12 December 2020

Direct electrochemistry of immobilized human cytochrome P450 2E1.

1 reference

12 December 2020

Evaluation of secondary structure of proteins from UV circular dichroism spectra using an unsupervised learning neural network.

1 reference

12 December 2020

Electron shuttle between membrane-bound cytochrome P450 3A4 and b5 rules uncoupling mechanisms

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12 December 2020

Crystal structure of human cytochrome P450 2C9 with bound warfarin

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12 December 2020

Cytochrome P450 and the individuality of species

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12 December 2020

Expression, purification, and biochemical characterization of a human cytochrome P450 CYP2D6-NADPH cytochrome P450 reductase fusion protein

1 reference

12 December 2020

Molecular Lego: design of molecular assemblies of P450 enzymes for nanobiotechnology

1 reference

12 December 2020

Denaturation of cytochrome P450 2B1 by guanidine hydrochloride and urea: evidence for a metastable intermediate state of the active site

1 reference

12 December 2020

The structure of human cytochrome P450 2C9 complexed with flurbiprofen at 2.0-A resolution

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12 December 2020

Purification of octyl beta-D-glucopyranoside and re-estimation of its micellar size

1 reference

12 December 2020

High catalytic activity of human cytochrome P450 co-expressed with human NADPH-cytochrome P450 reductase in Escherichia coli

1 reference

12 December 2020

Identification and characterization of two functional domains in cytochrome P-450BM-3, a catalytically self-sufficient monooxygenase induced by barbiturates in Bacillus megaterium

1 reference

12 December 2020

Assay of formaldehyde generated during microsomal oxidation reactions

1 reference

12 December 2020

Roles of key active-site residues in flavocytochrome P450 BM3

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12 December 2020

Functional Interactions in Cytochrome P450BM3: Flavin Semiquinone Intermediates, Role of NADP(H), and Mechanism of Electron Transfer by the Flavoprotein Domain†

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12 December 2020

Common and uncommon cytochrome P450 reactions related to metabolism and chemical toxicity

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12 December 2020

Human cytochrome P450 3A4-catalyzed testosterone 6 beta-hydroxylation and erythromycin N-demethylation. Competition during catalysis.

1 reference

12 December 2020

Biochemical characterization of rat P450 2C11 fused to rat or bacterial NADPH-P450 reductase domains

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12 December 2020

Redox control of the catalytic cycle of flavocytochrome P-450 BM3.

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12 December 2020

Fatty acid monooxygenation by cytochrome P-450BM-3.

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12 December 2020

P450 BM3: the very model of a modern flavocytochrome

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12 December 2020

Engineering microsomal cytochrome P450 2C5 to be a soluble, monomeric enzyme. Mutations that alter aggregation, phospholipid dependence of catalysis, and membrane binding

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12 December 2020

The dimeric form of flavocytochrome P450 BM3 is catalytically functional as a fatty acid hydroxylase.

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12 December 2020

Structural and enzymological analysis of the interaction of isolated domains of cytochrome P-450 BM3.

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12 December 2020

Expression of modified human cytochrome P450 3A4 in Escherichia coli and purification and reconstitution of the enzyme.

1 reference

12 December 2020

Construction of a human cytochrome P450 1A1: rat NADPH-cytochrome P450 reductase fusion protein cDNA and expression in Escherichia coli, purification, and catalytic properties of the enzyme in bacterial cells and after purification.

1 reference

12 December 2020

Characterization of a catalytically self-sufficient 119,000-dalton cytochrome P-450 monooxygenase induced by barbiturates in Bacillus megaterium.

1 reference

12 December 2020

Effect of mutations of ionic amino acids of cytochrome P450 1A2 on catalytic activities toward 7-ethoxycoumarin and methanol

1 reference

12 December 2020

10.1007/S00775-006-0144-3

Identifiers

DOI

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31 March 2018

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31 March 2018