(Q51393004)

4 April 2018

title

Exercise training reduces insulin resistance and upregulates the mTOR/p70S6k pathway in cardiac muscle of diet-induced obesity rats. (English)

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6

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Lício Velloso

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object named as

Lício A Velloso

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author name string

Cleber Medeiros

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Marisa J Frederico

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Gabrielle da Luz

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José R Pauli

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Adelino S R Silva

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Eduardo R Ropelle

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Cláudio T De Souza

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publication date

1 March 2011

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Journal of Cellular Physiology

published in

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volume

226

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issue

3

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page(s)

666-674

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No-flow ischemia inhibits insulin signaling in heart by decreasing intracellular pH.

cites work

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Insulin signalling in the heart

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Estimates of in vivo insulin action in man: comparison of insulin tolerance tests with euglycemic and hyperglycemic glucose clamp studies.

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Akt induces enhanced myocardial contractility and cell size in vivo in transgenic mice

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Integrin-linked kinase at the heart of cardiac contractility, repair, and disease.

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Raptor, a binding partner of target of rapamycin (TOR), mediates TOR action

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Upstream and downstream of mTOR

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A central role for JNK in obesity and insulin resistance

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Balancing muscle hypertrophy and atrophy

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PTEN expression contributes to the regulation of muscle protein degradation in diabetes.

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Cardiac muscle protein catabolism in diabetes mellitus: activation of the ubiquitin-proteasome system by insulin deficiency

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Lipid-induced insulin resistance in human muscle is associated with changes in diacylglycerol, protein kinase C, and IkappaB-alpha

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Myocardial protection by insulin at reperfusion requires early administration and is mediated via Akt and p70s6 kinase cell-survival signaling

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Activation or inactivation of cardiac Akt/mTOR signaling diverges physiological from pathological hypertrophy

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Inflammatory cytokines inhibit myogenic differentiation through activation of nuclear factor-kappaB.

21 January 2018

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Atrogin-1 inhibits Akt-dependent cardiac hypertrophy in mice via ubiquitin-dependent coactivation of Forkhead proteins

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The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate

21 January 2018

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Coordinate regulation of translation by the PI 3-kinase and mTOR pathways

21 January 2018

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Suppression of cardiomyocyte hypertrophy by inhibition of the ubiquitin-proteasome system

21 January 2018

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TNF induction of atrogin-1/MAFbx mRNA depends on Foxo4 expression but not AKT-Foxo1/3 signaling.

21 January 2018

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The transition from fetal growth restriction to accelerated postnatal growth: a potential role for insulin signalling in skeletal muscle.

21 January 2018

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The mammalian target of rapamycin (mTOR) partner, raptor, binds the mTOR substrates p70 S6 kinase and 4E-BP1 through their TOR signaling (TOS) motif

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Myocardial insulin action and the contribution of insulin resistance to the pathogenesis of diabetic cardiomyopathy.

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Regulation of protein kinase B and 4E-BP1 by oxidative stress in cardiac myocytes

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Regulation of cardiac myocyte protein synthesis through phosphatidylinositol 3' kinase and protein kinase B.

21 January 2018

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Tumor necrosis factor-alpha induces skeletal muscle insulin resistance in healthy human subjects via inhibition of Akt substrate 160 phosphorylation

21 January 2018

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Increased transcription of ubiquitin-proteasome system components: molecular responses associated with muscle atrophy

21 January 2018

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SOCS-1 and SOCS-3 block insulin signaling by ubiquitin-mediated degradation of IRS1 and IRS2

21 January 2018

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Foxo transcription factors induce the atrophy-related ubiquitin ligase atrogin-1 and cause skeletal muscle atrophy

21 January 2018

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Acute exercise increases triglyceride synthesis in skeletal muscle and prevents fatty acid-induced insulin resistance

21 January 2018

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A method for the simultaneous measurement of insulin release and B cell membrane potential in single mouse islets of Langerhans

21 January 2018

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Glucose phosphorylation is required for insulin-dependent mTOR signalling in the heart

21 January 2018

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Cardiac restricted overexpression of kinase-dead mammalian target of rapamycin (mTOR) mutant impairs the mTOR-mediated signaling and cardiac function

21 January 2018

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Akt/protein kinase B promotes organ growth in transgenic mice

21 January 2018

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Akt signaling mediates postnatal heart growth in response to insulin and nutritional status

21 January 2018

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Obesity as a cardiovascular risk factor

21 January 2018

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Reduced skeletal muscle inhibitor of kappaB beta content is associated with insulin resistance in subjects with type 2 diabetes: reversal by exercise training

21 January 2018

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Interleukin-6 markedly decreases skeletal muscle protein turnover and increases nonmuscle amino acid utilization in healthy individuals

21 January 2018

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Insulin resistance accelerates muscle protein degradation: Activation of the ubiquitin-proteasome pathway by defects in muscle cell signaling

21 January 2018

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21 January 2018

Identifiers

DOI

10.1002/JCP.22387

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