(Q51554260)

7 April 2018

title

Inhibition of mTOR with sirolimus does not attenuate progression of liver and kidney disease in PCK rats. (English)

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7 April 2018

Dagmar-Christiane Fischer

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2

object named as

Dagmar-Christiane Fischer

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7 April 2018

author name string

Catharina Renken

1

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7 April 2018

Günther Kundt

3

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7 April 2018

Norbert Gretz

4

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7 April 2018

Dieter Haffner

5

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7 April 2018

language of work or name

English

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publication date

7 July 2010

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7 April 2018

Nephrology Dialysis Transplantation

published in

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7 April 2018

volume

26

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7 April 2018

issue

1

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7 April 2018

page(s)

92-100

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7 April 2018

Diagnosis, pathogenesis, and treatment prospects in cystic kidney disease

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PKHD1, the polycystic kidney and hepatic disease 1 gene, encodes a novel large protein containing multiple immunoglobulin-like plexin-transcription-factor domains and parallel beta-helix 1 repeats

21 January 2018

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The gene mutated in autosomal recessive polycystic kidney disease encodes a large, receptor-like protein

21 January 2018

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G8: a novel domain associated with polycystic kidney disease and non-syndromic hearing loss

21 January 2018

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Proteolytic cleavage and nuclear translocation of fibrocystin is regulated by intracellular Ca2+ and activation of protein kinase C.

21 January 2018

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Polyductin undergoes notch-like processing and regulated release from primary cilia

21 January 2018

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Molecular basis of polycystic kidney disease: PKD1, PKD2 and PKHD1.

21 January 2018

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Fibrocystin/polyductin modulates renal tubular formation by regulating polycystin-2 expression and function

21 January 2018

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Polycystin-2 expression is regulated by a PC2-binding domain in the intracellular portion of fibrocystin

21 January 2018

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Fibrocystin/polyductin, found in the same protein complex with polycystin-2, regulates calcium responses in kidney epithelia.

21 January 2018

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Kinesin-2 mediates physical and functional interactions between polycystin-2 and fibrocystin.

21 January 2018

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A comparison of the predictive performance of different methods of kidney function estimation in a well-characterized HIV-infected population.

21 January 2018

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The mTOR pathway is regulated by polycystin-1, and its inhibition reverses renal cystogenesis in polycystic kidney disease

21 January 2018

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Inhibition of mTOR with sirolimus slows disease progression in Han:SPRD rats with autosomal dominant polycystic kidney disease (ADPKD).

21 January 2018

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Sirolimus reduces polycystic liver volume in ADPKD patients

21 January 2018

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Mitotic activation of Akt signalling pathway in Han:SPRD rats with polycystic kidney disease.

21 January 2018

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Clinical proof-of-concept trial to assess the therapeutic effect of sirolimus in patients with autosomal dominant polycystic kidney disease: SUISSE ADPKD study

21 January 2018

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Safety and tolerability of sirolimus treatment in patients with autosomal dominant polycystic kidney disease.

21 January 2018

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Activation of the AKT/mTOR pathway in autosomal recessive polycystic kidney disease (ARPKD).

21 January 2018

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Biliary dysgenesis in the PCK rat, an orthologous model of autosomal recessive polycystic kidney disease

21 January 2018

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Development and characterization of a cholangiocyte cell line from the PCK rat, an animal model of Autosomal Recessive Polycystic Kidney Disease

21 January 2018

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The pck rat: a new model that resembles human autosomal dominant polycystic kidney and liver disease

21 January 2018

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Simultaneous observation of collagen and elastin in normal and pathological tissues: analysis of Sirius-red-stained sections by fluorescence microscopy.

21 January 2018

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Src inhibition ameliorates polycystic kidney disease

21 January 2018

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Calcium channel inhibition accelerates polycystic kidney disease progression in the Cy/+ rat.

21 January 2018

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mTOR is out of control in polycystic kidney disease

21 January 2018

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Stress and mTORture signaling

21 January 2018

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Upstream and downstream of mTOR

21 January 2018

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The mTOR pathway in the control of protein synthesis

21 January 2018

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TOR signaling in growth and metabolism

21 January 2018

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Long-term rapamycin therapy in the Han:SPRD rat model of polycystic kidney disease (PKD).

21 January 2018

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Comparative study analyzing effects of sirolimus-cyclosporin and sirolimus-tacrolimus combinations on bile flow in the rat.

21 January 2018

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Rapamycin: something old, something new, sometimes borrowed and now renewed

21 January 2018

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https://api.crossref.org/works/10.1093%2FNDT%2FGFQ384

Upstream of the mammalian target of rapamycin: do all roads pass through mTOR?

21 January 2018

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https://api.crossref.org/works/10.1093%2FNDT%2FGFQ384

Signalling to translation: how signal transduction pathways control the protein synthetic machinery

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FNDT%2FGFQ384

Targeting mTOR with rapamycin: one dose does not fit all

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FNDT%2FGFQ384

4E-binding proteins, the suppressors of eukaryotic initiation factor 4E, are down-regulated in cells with acquired or intrinsic resistance to rapamycin

21 January 2018

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Rapamycin induces transactivation of the EGFR and increases cell survival

21 January 2018

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TOR complex 2: a signaling pathway of its own.

21 January 2018

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https://api.crossref.org/works/10.1093%2FNDT%2FGFQ384

Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FNDT%2FGFQ384

Predicted mechanisms of resistance to mTOR inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FNDT%2FGFQ384

The role of the mammalian target of rapamycin (mTOR) in renal disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FNDT%2FGFQ384

Epidermal growth factor receptor tyrosine kinase inhibition is not protective in PCK rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FNDT%2FGFQ384

21 January 2018

Identifiers

DOI

10.1093/NDT/GFQ384

1 reference

7 April 2018

1 reference

7 April 2018