(Q51555047)

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Diverse role of conformational dynamics in carboxypeptidase A-driven peptide and ester hydrolyses: disclosing the "perfect induced fit" and "protein local unfolding" pathways by altering protein stability.

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scholarly article

1 reference

Europe PubMed Central

7 April 2018

http://europepmc.org/abstract/MED/21698595

Diverse role of conformational dynamics in carboxypeptidase A-driven peptide and ester hydrolyses: disclosing the "perfect induced fit" and "protein local unfolding" pathways by altering protein stability. (English)

1 reference

Europe PubMed Central

7 April 2018

http://europepmc.org/abstract/MED/21698595

5

object named as

Rudi van Eldik

1 reference

Europe PubMed Central

7 April 2018

author name string

Mikhael Shushanyan

1

1 reference

Europe PubMed Central

7 April 2018

http://europepmc.org/abstract/MED/21698595

Dimitri E Khoshtariya

2

1 reference

Europe PubMed Central

7 April 2018

http://europepmc.org/abstract/MED/21698595

Tatyana Tretyakova

3

1 reference

Europe PubMed Central

7 April 2018

http://europepmc.org/abstract/MED/21698595

Maya Makharadze

4

1 reference

Europe PubMed Central

7 April 2018

http://europepmc.org/abstract/MED/21698595

publication date

22 June 2011

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Europe PubMed Central

7 April 2018

http://europepmc.org/abstract/MED/21698595

1 reference

Europe PubMed Central

7 April 2018

http://europepmc.org/abstract/MED/21698595

95

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Europe PubMed Central

7 April 2018

http://europepmc.org/abstract/MED/21698595

852-870

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Europe PubMed Central

7 April 2018

http://europepmc.org/abstract/MED/21698595

12

1 reference

Europe PubMed Central

7 April 2018

http://europepmc.org/abstract/MED/21698595

On the size of the active site in proteases. II. Carboxypeptidase-A.

1 reference

https://api.crossref.org/works/10.1002%2FBIP.21688

21 January 2018

Carboxypeptidase A. Differences in the mechanisms of ester and peptide hydrolysis

1 reference

https://api.crossref.org/works/10.1002%2FBIP.21688

21 January 2018

Bovine procarboxypeptidase A: kinetics of peptide and ester hydrolysis

1 reference

https://api.crossref.org/works/10.1002%2FBIP.21688

21 January 2018

Unified picture of mechanisms of catalysis by carboxypeptidase A

1 reference

https://api.crossref.org/works/10.1002%2FBIP.21688

21 January 2018

Comparison of the structures of three carboxypeptidase A-phosphonate complexes determined by X-ray crystallography

1 reference

https://api.crossref.org/works/10.1002%2FBIP.21688

21 January 2018

Three-dimensional structure of porcine pancreatic procarboxypeptidase A. A comparison of the A and B zymogens and their determinants for inhibition and activation.

1 reference

https://api.crossref.org/works/10.1002%2FBIP.21688

21 January 2018

Zinc coordination, function, and structure of zinc enzymes and other proteins

1 reference

https://api.crossref.org/works/10.1002%2FBIP.21688

21 January 2018

Kinetics of carboxypeptidase A. I. Hydrolysis of carbobenzoxyglycyl-l-phenylalanine, benzoylglycyl-l-phenylalanine, and hippuryl-dl-beta-phenyllactic acid by metal-substituted and acetylated carboxypeptidases

1 reference

https://api.crossref.org/works/10.1002%2FBIP.21688

21 January 2018

Kinetics of carboxypeptidase A. II. Inhibitors of the hydrolysis of oligopeptides

1 reference

https://api.crossref.org/works/10.1002%2FBIP.21688

21 January 2018

Mechanism of action of carboxypeptidase A in ester hydrolysis

1 reference

https://api.crossref.org/works/10.1002%2FBIP.21688

21 January 2018

Site-directed mutagenesis shows that tyrosine 248 of carboxypeptidase A does not play a crucial role in catalysis

1 reference

https://api.crossref.org/works/10.1002%2FBIP.21688

21 January 2018

Substrate specificity of solvent viscosity effects in carboxypeptidase A catalyzed peptide hydrolysis.

1 reference

https://api.crossref.org/works/10.1002%2FBIP.21688

21 January 2018

Hippuryl-alpha-methylphenylalanine and hippuryl-alpha-methylphenyllactic acid as substrates for carboxypeptidase A. Syntheses, kinetic evaluation and mechanistic implication

1 reference

https://api.crossref.org/works/10.1002%2FBIP.21688

21 January 2018

The role of Tyr248 probed by mutant bovine carboxypeptidase A: insight into the catalytic mechanism of carboxypeptidase A.

1 reference

https://api.crossref.org/works/10.1002%2FBIP.21688

21 January 2018

Inhibition Effects in the Hydrolysis Reactions of Esters and Peptides Catalyzed by Carboxypeptidase A: An Example of Cooperative Binding Effects with a Monomeric Enzyme

1 reference

https://api.crossref.org/works/10.1002%2FBIP.21688

21 January 2018

On the origin of the catalytic power of carboxypeptidase A and other metalloenzymes

1 reference

https://api.crossref.org/works/10.1002%2FBIP.21688

21 January 2018

Quantum mechanical/molecular mechanical and density functional theory studies of a prototypical zinc peptidase (carboxypeptidase A) suggest a general acid-general base mechanism

1 reference

https://api.crossref.org/works/10.1002%2FBIP.21688

21 January 2018

Catalysis of carboxypeptidase A: promoted-water versus nucleophilic pathways.

1 reference

https://api.crossref.org/works/10.1002%2FBIP.21688

21 January 2018

The effect of temperature on the individual stages of the hydrolysis of non-specific-p-nitrophenol esters by alpha-chymotrypsin

1 reference

https://api.crossref.org/works/10.1002%2FBIP.21688

21 January 2018

The specificity in the elementary steps of alpha-chymotrypsin catalysis. A temperature study with a series of N-acetyl-L-amino acid methyl esters.

1 reference

https://api.crossref.org/works/10.1002%2FBIP.21688

21 January 2018

A method to describe enzyme-catalyzed reactions by combining steady state and time course enzyme kinetic parameters

1 reference

https://api.crossref.org/works/10.1002%2FBIP.21688

21 January 2018

Explicit reformulations of time-dependent solution for a Michaelis-Menten enzyme reaction model.

1 reference

https://api.crossref.org/works/10.1002%2FBIP.21688

21 January 2018

Viscosity-dependent structural fluctuations in enzyme catalysis

1 reference

https://api.crossref.org/works/10.1002%2FBIP.21688

21 January 2018

Solvent viscosity and protein dynamics

1 reference

https://api.crossref.org/works/10.1002%2FBIP.21688

21 January 2018

Thermodynamic Quantities for the Ionization Reactions of Buffers

1 reference

https://api.crossref.org/works/10.1002%2FBIP.21688

21 January 2018

The kinetics of some carboxypeptidase A and acetylcarboxypeptidase A catalyzed hydrolyses.

1 reference

https://api.crossref.org/works/10.1002%2FBIP.21688

21 January 2018

Chemical and Electrochemical Electron-Transfer Theory

1 reference

https://api.crossref.org/works/10.1002%2FBIP.21688

21 January 2018

Electron transfers in chemistry and biology

1 reference

https://api.crossref.org/works/10.1002%2FBIP.21688

21 January 2018

H and other transfers in enzymes and in solution: theory and computations, a unified view. 2. Applications to experiment and computations.

1 reference

https://api.crossref.org/works/10.1002%2FBIP.21688

21 January 2018

Multidimensional tunneling, recrossing, and the transmission coefficient for enzymatic reactions

1 reference

https://api.crossref.org/works/10.1002%2FBIP.21688

21 January 2018

Kinetics of carboxypeptidase A. pH and temperature dependence of tripeptide hydrolysis

1 reference

https://api.crossref.org/works/10.1002%2FBIP.21688

21 January 2018

Counteraction of urea by trimethylamine N-oxide is due to direct interaction

1 reference

https://api.crossref.org/works/10.1002%2FBIP.21688

21 January 2018

Influence of osmolytes and denaturants on the structure and enzyme activity of alpha-chymotrypsin.

1 reference

https://api.crossref.org/works/10.1002%2FBIP.21688

21 January 2018

Rate theories and puzzles of hemeprotein kinetics

1 reference

https://api.crossref.org/works/10.1002%2FBIP.21688

21 January 2018

The mechanism of the proton transfer: an outline

1 reference

https://api.crossref.org/works/10.1002%2FBIP.21688

21 January 2018

Fluctuations in biological and bioinspired electron-transfer reactions

1 reference

https://api.crossref.org/works/10.1002%2FBIP.21688

21 January 2018

Effect of D2O on the carboxypeptidase-catalyzed hydrolysis of O-(trans-cinnamoyl)-L-beta-phenyllactate and N-(N-benzoylglycyl)-L-phenylalanine

1 reference

https://api.crossref.org/works/10.1002%2FBIP.21688

21 January 2018

Charge-transfer mechanism for cytochrome c adsorbed on nanometer thick films. Distinguishing frictional control from conformational gating.

1 reference

https://api.crossref.org/works/10.1002%2FBIP.21688

21 January 2018

Kinetic, thermodynamic, and mechanistic patterns for free (unbound) cytochrome c at Au/SAM junctions: impact of electronic coupling, hydrostatic pressure, and stabilizing/denaturing additives.

1 reference

https://api.crossref.org/works/10.1002%2FBIP.21688

21 January 2018

Fundamental signatures of short- and long-range electron transfer for the blue copper protein azurin at Au/SAM junctions

1 reference

https://api.crossref.org/works/10.1002%2FBIP.21688

21 January 2018

The Energy Landscapes and Motions of Proteins

1 reference

https://api.crossref.org/works/10.1002%2FBIP.21688

21 January 2018

A hierarchy of functionally important relaxations within myoglobin based on solvent effects, mutations and kinetic model

1 reference

https://api.crossref.org/works/10.1002%2FBIP.21688

21 January 2018

Linkage between dynamics and catalysis in a thermophilic-mesophilic enzyme pair

1 reference

https://api.crossref.org/works/10.1002%2FBIP.21688

21 January 2018

Intrinsic motions along an enzymatic reaction trajectory

1 reference

https://api.crossref.org/works/10.1002%2FBIP.21688

21 January 2018

Dynamic personalities of proteins

1 reference

https://api.crossref.org/works/10.1002%2FBIP.21688

21 January 2018

Role of conformation transitions in adenylate kinase

1 reference

https://api.crossref.org/works/10.1002%2FBIP.21688

21 January 2018

Theory of protein folding: the energy landscape perspective

1 reference

https://api.crossref.org/works/10.1002%2FBIP.21688

21 January 2018

Searching for "downhill scenarios" in protein folding

1 reference

https://api.crossref.org/works/10.1002%2FBIP.21688

21 January 2018

Protein folding and unfolding at atomic resolution

1 reference

https://api.crossref.org/works/10.1002%2FBIP.21688

21 January 2018

Direct observation of ultrafast folding and denatured state dynamics in single protein molecules

1 reference

https://api.crossref.org/works/10.1002%2FBIP.21688

21 January 2018

Kinetics of chain motions within a protein-folding intermediate

1 reference

https://api.crossref.org/works/10.1002%2FBIP.21688

21 January 2018

Thermal unfolding kinetics of ubiquitin in the microsecond-to-second time range probed by Tyr-59 fluorescence.

1 reference

https://api.crossref.org/works/10.1002%2FBIP.21688

21 January 2018

Dynamics of biochemical and biophysical reactions: insight from computer simulations

1 reference

https://api.crossref.org/works/10.1002%2FBIP.21688

21 January 2018

Enzyme millisecond conformational dynamics do not catalyze the chemical step

1 reference

https://api.crossref.org/works/10.1002%2FBIP.21688

21 January 2018

Reexamination of induced fit as a determinant of substrate specificity in enzymatic reactions.

1 reference

https://api.crossref.org/works/10.1002%2FBIP.21688

21 January 2018

Role of induced fit in enzyme specificity: a molecular forward/reverse switch

1 reference

https://api.crossref.org/works/10.1002%2FBIP.21688

21 January 2018

Multiple mechanisms for elongation processivity within the reconstituted tetrahymena telomerase holoenzyme

1 reference

https://api.crossref.org/works/10.1002%2FBIP.21688

21 January 2018

Nonlinear elasticity, proteinquakes, and the energy landscapes of functional transitions in proteins

1 reference

https://api.crossref.org/works/10.1002%2FBIP.21688

21 January 2018

Energy landscape along an enzymatic reaction trajectory: hinges or cracks?

1 reference

https://api.crossref.org/works/10.1002%2FBIP.21688

21 January 2018

A thermodynamic approach to the problem of stabilization of globular protein structure: a calorimetric study

1 reference

https://api.crossref.org/works/10.1002%2FBIP.21688

21 January 2018

Protein dynamics control the kinetics of initial electron transfer in photosynthesis

1 reference

https://api.crossref.org/works/10.1002%2FBIP.21688

21 January 2018

Biochemistry. Photosynthesis from the protein's perspective

1 reference

https://api.crossref.org/works/10.1002%2FBIP.21688

21 January 2018

Reply to Karplus: Conformational dynamics have no role in the chemical step

1 reference

https://api.crossref.org/works/10.1002%2FBIP.21688

21 January 2018

Identifiers

10.1002/BIP.21688

1 reference

Europe PubMed Central

7 April 2018

http://europepmc.org/abstract/MED/21698595

1 reference

Europe PubMed Central

7 April 2018

http://europepmc.org/abstract/MED/21698595

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