(Q34574339)

3 August 2017

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title

Protein folding and unfolding at atomic resolution (English)

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3 August 2017

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1

Alan R Fersht

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3 August 2017

2

Valerie Daggett

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PubMed ID

11909527

3 August 2017

language of work or name

English

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publication date

1 February 2002

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3 August 2017

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3 August 2017

108

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3 August 2017

573-582

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3 August 2017

4

1 reference

Contributions of hydrogen bonds of Thr 157 to the thermodynamic stability of phage T4 lysozyme

3 August 2017

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900620-7

7 January 2021

Can non-mechanical proteins withstand force? Stretching barnase by atomic force microscopy and molecular dynamics simulation.

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900620-7

7 January 2021

Characterization of residual structure in the thermally denatured state of barnase by simulation and experiment: description of the folding pathway

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900620-7

7 January 2021

Funnels, pathways, and the energy landscape of protein folding: a synthesis

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900620-7

7 January 2021

Molecular dynamics simulation of protein denaturation: solvation of the hydrophobic cores and secondary structure of barnase

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900620-7

7 January 2021

Acid and thermal denaturation of barnase investigated by molecular dynamics simulations

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900620-7

7 January 2021

Toward a mechanism for GroEL.GroES chaperone activity: an ATPase-gated and -pulsed folding and annealing cage

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900620-7

7 January 2021

Long timescale simulations

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https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900620-7

7 January 2021

A model of the molten globule state from molecular dynamics simulations

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900620-7

7 January 2021

Structure of the transition state for folding of a protein derived from experiment and simulation.

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900620-7

7 January 2021

Submillisecond kinetics of protein folding

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900620-7

7 January 2021

Using flexible loop mimetics to extend -value analysis to secondary structure interactions

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900620-7

7 January 2021

Optimization of rates of protein folding: the nucleation-condensation mechanism and its implications

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900620-7

7 January 2021

Nucleation mechanisms in protein folding

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900620-7

7 January 2021

Quantitative analysis of structure–activity relationships in engineered proteins by linear free-energy relationships

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900620-7

7 January 2021

Structure-activity relationships in engineered proteins: analysis of use of binding energy by linear free energy relationships

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900620-7

7 January 2021

The folding of an enzyme. I. Theory of protein engineering analysis of stability and pathway of protein folding

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900620-7

7 January 2021

Single versus parallel pathways of protein folding and fractional formation of structure in the transition state

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900620-7

7 January 2021

Mapping the folding pathway of an immunoglobulin domain: structural detail from Phi value analysis and movement of the transition state

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900620-7

7 January 2021

Folding of a nascent polypeptide chain in vitro: cooperative formation of structure in a protein module.

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900620-7

7 January 2021

Mapping the conformational wave of acetylcholine receptor channel gating

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900620-7

7 January 2021

Mitochondria Unfold Precursor Proteins by Unraveling Them From Their N-termini

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900620-7

7 January 2021

The Structure of the Transition State for Folding of Chymotrypsin Inhibitor 2 Analysed by Protein Engineering Methods: Evidence for a Nucleation-condensation Mechanism for Protein Folding

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900620-7

7 January 2021

Folding of chymotrypsin inhibitor 2. 1. Evidence for a two-state transition

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900620-7

7 January 2021

The folding mechanism of a beta-sheet: the WW domain

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900620-7

7 January 2021

Protein folding dynamics: the diffusion-collision model and experimental data

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900620-7

7 January 2021

Protein folding from a highly disordered denatured state: the folding pathway of chymotrypsin inhibitor 2 at atomic resolution

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900620-7

7 January 2021

Specific intermediates in the folding reactions of small proteins and the mechanism of protein folding

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900620-7

7 January 2021

Synergy between simulation and experiment in describing the energy landscape of protein folding

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900620-7

7 January 2021

"New view" of protein folding reconciled with the old through multiple unfolding simulations.

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900620-7

7 January 2021

ATP-dependent proteases degrade their substrates by processively unraveling them from the degradation signal

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900620-7

7 January 2021

Characterization of the transition state of protein unfolding by use of molecular dynamics: chymotrypsin inhibitor 2

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900620-7

7 January 2021

Identification and characterization of the unfolding transition state of chymotrypsin inhibitor 2 by molecular dynamics simulations.

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900620-7

7 January 2021

Molecular dynamics simulation of the unfolding of barnase: characterization of the major intermediate.

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900620-7

7 January 2021

Constructing, verifying, and dissecting the folding transition state of chymotrypsin inhibitor 2 with all-atom simulations

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900620-7

7 January 2021

Mapping the transition state and pathway of protein folding by protein engineering

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900620-7

7 January 2021

Exploring the energy surface of protein folding by structure-reactivity relationships and engineered proteins: observation of Hammond behavior for the gross structure of the transition state and anti-Hammond behavior for structural elements for unfo

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900620-7

7 January 2021

Protein folding and unfolding in microseconds to nanoseconds by experiment and simulation

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900620-7

7 January 2021

Dynamics of folded proteins

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900620-7

7 January 2021

Exploring the folding funnel of a polypeptide chain by biophysical studies on protein fragments

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900620-7

7 January 2021

Following co-operative formation of secondary and tertiary structure in a single protein module

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900620-7

7 January 2021

Characterisation of the transition states for protein folding: towards a new level of mechanistic detail in protein engineering analysis

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900620-7

7 January 2021

The energy landscape theory of protein folding: insights into folding mechanisms and scenarios

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900620-7

7 January 2021

Structure of the transition state for the folding/unfolding of the barley chymotrypsin inhibitor 2 and its implications for mechanisms of protein folding.

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900620-7

7 January 2021

The folding of an enzyme. III. Structure of the transition state for unfolding of barnase analysed by a protein engineering procedure

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900620-7

7 January 2021

Conserved residues and the mechanism of protein folding

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900620-7

7 January 2021

From folding theories to folding proteins: a review and assessment of simulation studies of protein folding and unfolding

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900620-7

7 January 2021

Guanidine hydrochloride denaturation studies of mutant forms of staphylococcal nuclease

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900620-7

7 January 2021

Persistence of native-like topology in a denatured protein in 8 M urea

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900620-7

7 January 2021

Three key residues form a critical contact network in a protein folding transition state

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900620-7

7 January 2021

Characterization of the active intermediate of a GroEL-GroES-mediated protein folding reaction

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900620-7

7 January 2021

Towards a complete description of the structural and dynamic properties of the denatured state of barnase and the role of residual structure in folding

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900620-7

7 January 2021

Beta-hairpin folding simulations in atomistic detail using an implicit solvent model

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900620-7

7 January 2021

10.1016/S0092-8674(02)00620-7

Identifiers

DOI

1 reference

3 August 2017

1 reference

PubMed ID

11909527