(Q51601398)

7 April 2018

title

Runx2/Cbfa1 stimulates transdifferentiation of primary skeletal myoblasts into a mineralizing osteoblastic phenotype. (English)

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7 April 2018

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3

Grace K Pavlath

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7 April 2018

author name string

Charles A Gersbach

series ordinal

1

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7 April 2018

Benjamin A Byers

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2

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7 April 2018

Andrés J García

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4

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7 April 2018

language of work or name

English

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publication date

1 November 2004

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7 April 2018

Experimental Cell Research

published in

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7 April 2018

volume

300

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7 April 2018

issue

2

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7 April 2018

page(s)

406-417

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7 April 2018

Bone morphogenetic proteins: an update on basic biology and clinical relevance

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Runx2 is a common target of transforming growth factor beta1 and bone morphogenetic protein 2, and cooperation between Runx2 and Smad5 induces osteoblast-specific gene expression in the pluripotent mesenchymal precursor cell line C2C12.

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7 January 2021

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Bone morphogenetic protein 2 transiently enhances expression of a gene, Id (inhibitor of differentiation), encoding a helix-loop-helix molecule in osteoblast-like cells

7 January 2021

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Osf2/Cbfa1: a transcriptional activator of osteoblast differentiation

7 January 2021

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Targeted disruption of Cbfa1 results in a complete lack of bone formation owing to maturational arrest of osteoblasts

7 January 2021

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Mutations involving the transcription factor CBFA1 cause cleidocranial dysplasia

7 January 2021

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A RUNX2/PEBP2alpha A/CBFA1 mutation displaying impaired transactivation and Smad interaction in cleidocranial dysplasia

7 January 2021

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Cell-type-dependent up-regulation of in vitro mineralization after overexpression of the osteoblast-specific transcription factor Runx2/Cbfal

7 January 2021

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Structural basis of BMP signalling inhibition by the cystine knot protein Noggin

7 January 2021

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Noggin arrests stromal cell differentiation in vitro☆☆This work was supported by Grant AR21707 from the National Institute of Arthritis and Musculoskeletal and Skin Diseases, and Grant DK45227 from the National Institute of Diabetes, Digestive an

7 January 2021

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A SMAD ubiquitin ligase targets the BMP pathway and affects embryonic pattern formation

7 January 2021

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Smurf1 facilitates myogenic differentiation and antagonizes the bone morphogenetic protein-2-induced osteoblast conversion by targeting Smad5 for degradation

7 January 2021

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The mammalian basic helix loop helix protein HES-1 binds to and modulates the transactivating function of the runt-related factor Cbfa1

7 January 2021

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Ectopic Msx2 overexpression inhibits and Msx2 antisense stimulates calvarial osteoblast differentiation

7 January 2021

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Regulation of the activity of the transcription factor Runx2 by two homeobox proteins, Msx2 and Dlx5

7 January 2021

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BMP-2-induced Runx2 expression is mediated by Dlx5, and TGF-beta 1 opposes the BMP-2-induced osteoblast differentiation by suppression of Dlx5 expression

7 January 2021

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Expression and regulation of Runx2/Cbfa1 and osteoblast phenotypic markers during the growth and differentiation of human osteoblasts

7 January 2021

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In vitro and in vivo synergistic interactions between the Runx2/Cbfa1 transcription factor and bone morphogenetic protein-2 in stimulating osteoblast differentiation

7 January 2021

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Transplantation of skin fibroblasts expressing BMP-2 promotes bone repair more effectively than those expressing Runx2

7 January 2021

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Primary mouse myoblast purification, characterization, and transplantation for cell-mediated gene therapy

7 January 2021

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Cbfa1 isoforms exert functional differences in osteoblast differentiation

7 January 2021

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High-efficiency retroviral infection of primary myoblasts

7 January 2021

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The mature osteoblast phenotype is characterized by extensive plasticity

7 January 2021

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Molecular markers of bone turnover: biochemical, technical and analytical aspects.

7 January 2021

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The novel zinc finger-containing transcription factor osterix is required for osteoblast differentiation and bone formation

7 January 2021

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Overexpression of Dlx5 in chicken calvarial cells accelerates osteoblastic differentiation

7 January 2021

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Differential roles for bone morphogenetic protein (BMP) receptor type IB and IA in differentiation and specification of mesenchymal precursor cells to osteoblast and adipocyte lineages

7 January 2021

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Role of Runx genes in chondrocyte differentiation

7 January 2021

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Plasticity of adult stem cells

7 January 2021

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Muscle-derived stem cells

7 January 2021

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Bone morphogenetic proteins, extracellular matrix, and mitogen-activated protein kinase signaling pathways are required for osteoblast-specific gene expression and differentiation in MC3T3-E1 cells

7 January 2021

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Protein kinase C-independent activation of protein kinase D is involved in BMP-2-induced activation of stress mitogen-activated protein kinases JNK and p38 and osteoblastic cell differentiation

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2004.07.031

Bone morphogenetic protein-2 promotes osteoblast apoptosis through a Smad-independent, protein kinase C-dependent signaling pathway

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2004.07.031

MAPK pathways activate and phosphorylate the osteoblast-specific transcription factor, Cbfa1.

7 January 2021

1 reference

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Activation of mitogen-activated protein kinase cascades is involved in regulation of bone morphogenetic protein-2-induced osteoblast differentiation in pluripotent C2C12 cells

7 January 2021

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Initiation of Smad-dependent and Smad-independent signaling via distinct BMP-receptor complexes.

7 January 2021

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Stimulation of Smad1 transcriptional activity by Ras-extracellular signal-regulated kinase pathway: a possible mechanism for collagen-dependent osteoblastic differentiation

7 January 2021

1 reference

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Activation of p38 Mitogen-Activated Protein Kinase and c-Jun-NH2-Terminal Kinase by BMP-2 and Their Implication in the Stimulation of Osteoblastic Cell Differentiation

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2004.07.031

Both the Smad and p38 MAPK pathways play a crucial role in Runx2 expression following induction by transforming growth factor-beta and bone morphogenetic protein

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2004.07.031

Osteoprogenitor cells within skeletal muscle

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2004.07.031

Translational regulation is a control point in RUNX2/Cbfa1 gene expression

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2004.07.031

Fibroblast growth factor 2 induction of the osteocalcin gene requires MAPK activity and phosphorylation of the osteoblast transcription factor, Cbfa1/Runx2.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2004.07.031

The bone-specific transcriptional regulator Cbfa1 is a target of mechanical signals in osteoblastic cells.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2004.07.031

Parathyroid hormone regulation of the rat collagenase-3 promoter by protein kinase A-dependent transactivation of core binding factor alpha1.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2004.07.031

Regulation of the osteoblast-specific transcription factor, Runx2: responsiveness to multiple signal transduction pathways

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2004.07.031

Expression of the osteoblast differentiation factor RUNX2 (Cbfa1/AML3/Pebp2alpha A) is inhibited by tumor necrosis factor-alpha

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2004.07.031

BMP-2-induced Osterix expression is mediated by Dlx5 but is independent of Runx2.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2004.07.031

Mechanism of action of beta-glycerophosphate on bone cell mineralization

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2004.07.031

von Kossa staining alone is not sufficient to confirm that mineralization in vitro represents bone formation

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2004.07.031

10.1016/J.YEXCR.2004.07.031

7 January 2021

Identifiers

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7 April 2018

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7 April 2018