(Q51608953)

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Copper(I) and copper(II) inhibit Aβ peptides proteolysis by insulin-degrading enzyme differently: implications for metallostasis alteration in Alzheimer's disease.

scientific article published on 27 January 2011

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Europe PubMed Central

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21 January 2020

Copper(I) and copper(II) inhibit Aβ peptides proteolysis by insulin-degrading enzyme differently: implications for metallostasis alteration in Alzheimer's disease (English)

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21 January 2020

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Giuseppe Grasso

1

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21 January 2020

Enrico Rizzarelli

8

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21 January 2020

Adriana Pietropaolo

2

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21 January 2020

Giuseppe Pappalardo

4

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21 January 2020

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Giuseppe Spoto

3

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21 January 2020

Grazia Raffaella Tundo

5

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21 January 2020

Chiara Ciaccio

6

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21 January 2020

Massimo Coletta

7

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21 January 2020

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27 January 2011

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21 January 2020

Chemistry—A European Journal

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21 January 2020

17

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21 January 2020

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21 January 2020

2752-2762

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21 January 2020

Roles of amyloid beta-peptide-associated oxidative stress and brain protein modifications in the pathogenesis of Alzheimer's disease and mild cognitive impairment

1 reference

https://api.crossref.org/works/10.1002%2FCHEM.201002809

21 January 2018

Oligomeric and fibrillar species of amyloid-beta peptides differentially affect neuronal viability.

1 reference

https://api.crossref.org/works/10.1002%2FCHEM.201002809

21 January 2018

Insulin-degrading enzyme regulates extracellular levels of amyloid beta-protein by degradation

1 reference

https://api.crossref.org/works/10.1002%2FCHEM.201002809

21 January 2018

Metal ion physiopathology in neurodegenerative disorders

1 reference

https://api.crossref.org/works/10.1002%2FCHEM.201002809

21 January 2018

Therapeutics for Alzheimer's disease based on the metal hypothesis

1 reference

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21 January 2018

Zinc in the physiology and pathology of the CNS.

1 reference

https://api.crossref.org/works/10.1002%2FCHEM.201002809

21 January 2018

Copper in the brain and Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1002%2FCHEM.201002809

21 January 2018

Therapeutic treatments for Alzheimer's disease based on metal bioavailability

1 reference

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21 January 2018

The role of metals in modulating metalloprotease activity in the AD brain.

1 reference

https://api.crossref.org/works/10.1002%2FCHEM.201002809

21 January 2018

Copper inhibits beta-amyloid production and stimulates the non-amyloidogenic pathway of amyloid-precursor-protein secretion

1 reference

https://api.crossref.org/works/10.1002%2FCHEM.201002809

21 January 2018

Dietary Cu stabilizes brain superoxide dismutase 1 activity and reduces amyloid Abeta production in APP23 transgenic mice

1 reference

https://api.crossref.org/works/10.1002%2FCHEM.201002809

21 January 2018

In vivo reduction of amyloid-beta by a mutant copper transporter

1 reference

https://api.crossref.org/works/10.1002%2FCHEM.201002809

21 January 2018

Synchrotron X-ray imaging reveals a correlation of tumor copper speciation with Clioquinol's anticancer activity

1 reference

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21 January 2018

Amyloid beta-degrading cryptidases: insulin degrading enzyme, presequence peptidase, and neprilysin

1 reference

https://api.crossref.org/works/10.1002%2FCHEM.201002809

21 January 2018

The proteolytic activity of insulin-degrading enzyme: a mass spectrometry study

1 reference

https://api.crossref.org/works/10.1002%2FCHEM.201002809

21 January 2018

Restored degradation of the Alzheimer's amyloid-beta peptide by targeting amyloid formation

1 reference

https://api.crossref.org/works/10.1002%2FCHEM.201002809

21 January 2018

Degradation of the Alzheimer disease amyloid beta-peptide by metal-dependent up-regulation of metalloprotease activity

1 reference

https://api.crossref.org/works/10.1002%2FCHEM.201002809

21 January 2018

Increasing Cu bioavailability inhibits Abeta oligomers and tau phosphorylation

1 reference

https://api.crossref.org/works/10.1002%2FCHEM.201002809

21 January 2018

The insulysin (insulin degrading enzyme) enigma

1 reference

https://api.crossref.org/works/10.1002%2FCHEM.201002809

21 January 2018

Insulin degrading enzyme is localized predominantly at the cell surface of polarized and unpolarized human cerebrovascular endothelial cell cultures

1 reference

https://api.crossref.org/works/10.1002%2FCHEM.201002809

21 January 2018

Alternative splicing of human insulin-degrading enzyme yields a novel isoform with a decreased ability to degrade insulin and amyloid beta-protein

1 reference

https://api.crossref.org/works/10.1002%2FCHEM.201002809

21 January 2018

Hyperinsulinemia and risk of Alzheimer disease.

1 reference

https://api.crossref.org/works/10.1002%2FCHEM.201002809

21 January 2018

Neprilysin and insulin-degrading enzyme levels are increased in Alzheimer disease in relation to disease severity

1 reference

https://api.crossref.org/works/10.1002%2FCHEM.201002809

21 January 2018

Structures of human insulin-degrading enzyme reveal a new substrate recognition mechanism

1 reference

https://api.crossref.org/works/10.1002%2FCHEM.201002809

21 January 2018

An unusual active site identified in a family of zinc metalloendopeptidases

1 reference

https://api.crossref.org/works/10.1002%2FCHEM.201002809

21 January 2018

Insulin, insulin-degrading enzyme and amyloid-beta peptide in Alzheimer's disease: review and hypothesis.

1 reference

https://api.crossref.org/works/10.1002%2FCHEM.201002809

21 January 2018

Molecular Bases for the Recognition of Short Peptide Substrates and Cysteine-Directed Modifications of Human Insulin-Degrading Enzyme †

1 reference

https://api.crossref.org/works/10.1002%2FCHEM.201002809

21 January 2018

Molecular basis for the thiol sensitivity of insulin-degrading enzyme

1 reference

https://api.crossref.org/works/10.1002%2FCHEM.201002809

21 January 2018

Protective role of Cys-178 against the inactivation and oligomerization of human insulin-degrading enzyme by oxidation and nitrosylation

1 reference

https://api.crossref.org/works/10.1002%2FCHEM.201002809

21 January 2018

Nitric oxide inhibits insulin-degrading enzyme activity and function through S-nitrosylation

1 reference

https://api.crossref.org/works/10.1002%2FCHEM.201002809

21 January 2018

Somatostatin: a novel substrate and a modulator of insulin-degrading enzyme activity

1 reference

https://api.crossref.org/works/10.1002%2FCHEM.201002809

21 January 2018

How the binding and degrading capabilities of insulin degrading enzyme are affected by ubiquitin

1 reference

https://api.crossref.org/works/10.1002%2FCHEM.201002809

21 January 2018

Structural and functional implications of metal ion selection in aminopeptidase P, a metalloprotease with a dinuclear metal center.

1 reference

https://api.crossref.org/works/10.1002%2FCHEM.201002809

21 January 2018

The Cu(II) complex of Abeta40 peptide in ammonium acetate solutions. Evidence for ternary species formation

1 reference

https://api.crossref.org/works/10.1002%2FCHEM.201002809

21 January 2018

Copper homeostasis and neurodegenerative disorders (Alzheimer's, prion, and Parkinson's diseases and amyotrophic lateral sclerosis).

1 reference

https://api.crossref.org/works/10.1002%2FCHEM.201002809

21 January 2018

Molecular Basis for the Recognition and Cleavages of IGF-II, TGF-α, and Amylin by Human Insulin-Degrading Enzyme

1 reference

https://api.crossref.org/works/10.1002%2FCHEM.201002809

21 January 2018

Metal loading capacity of Abeta N-terminus: a combined potentiometric and spectroscopic study of zinc(II) complexes with Abeta(1-16), its short or mutated peptide fragments and its polyethylene glycol-ylated analogue

1 reference

https://api.crossref.org/works/10.1002%2FCHEM.201002809

21 January 2018

Insulin-degrading enzyme is exported via an unconventional protein secretion pathway

1 reference

https://api.crossref.org/works/10.1002%2FCHEM.201002809

21 January 2018

AP/MALDI-MS complete characterization of the proteolytic fragments produced by the interaction of insulin degrading enzyme with bovine insulin

1 reference

https://api.crossref.org/works/10.1002%2FCHEM.201002809

21 January 2018

A bis-acetonitrile two-coordinate copper(I) complex: synthesis and characterization of highly soluble B(C(6)F(5))(4)(-) salts of [Cu(MeCN)(2)](+) and [Cu(MeCN)(4)](+).

1 reference

https://api.crossref.org/works/10.1002%2FCHEM.201002809

21 January 2018

Structure of substrate-free human insulin-degrading enzyme (IDE) and biophysical analysis of ATP-induced conformational switch of IDE

1 reference

https://api.crossref.org/works/10.1002%2FCHEM.201002809

21 January 2018

Scalable molecular dynamics with NAMD

1 reference

https://api.crossref.org/works/10.1002%2FCHEM.201002809

21 January 2018

Comparison of simple potential functions for simulating liquid water

1 reference

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21 January 2018

New model potentials for sulfur-copper(I) and sulfur-mercury(II) interactions in proteins: from ab initio to molecular dynamics.

1 reference

https://api.crossref.org/works/10.1002%2FCHEM.201002809

21 January 2018

Solution structure of the Cu(I) and apo forms of the yeast metallochaperone, Atx1

1 reference

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21 January 2018

Evaluation of the efficiency of in-gel digestion of proteins by peptide isotopic labeling and MALDI mass spectrometry

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21 January 2018

Degradation of soluble amyloid beta-peptides 1-40, 1-42, and the Dutch variant 1-40Q by insulin degrading enzyme from Alzheimer disease and control brains.

1 reference

https://api.crossref.org/works/10.1002%2FCHEM.201002809

21 January 2018

The Cu(II)/Abeta/human serum albumin model of control mechanism for copper-related amyloid neurotoxicity

1 reference

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21 January 2018

High-resolution NMR studies of the zinc-binding site of the Alzheimer's amyloid beta-peptide.

1 reference

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21 January 2018

Identifying the minimal copper- and zinc-binding site sequence in amyloid-beta peptides

1 reference

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21 January 2018

Metal binding modes of Alzheimer's amyloid beta-peptide in insoluble aggregates and soluble complexes.

1 reference

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21 January 2018

The catalytic domain of insulin-degrading enzyme forms a denaturant-resistant complex with amyloid beta peptide: implications for Alzheimer disease pathogenesis

1 reference

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21 January 2018

Elucidation of insulin degrading enzyme catalyzed site specific hydrolytic cleavage of amyloid beta peptide: a comparative density functional theory study.

1 reference

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21 January 2018

Elucidation of interactions of Alzheimer amyloid beta peptides (Abeta40 and Abeta42) with insulin degrading enzyme: a molecular dynamics study

1 reference

https://api.crossref.org/works/10.1002%2FCHEM.201002809

21 January 2018

Human insulin-degrading enzyme working mechanism

1 reference

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21 January 2018

Particle mesh Ewald: An N⋅log(N) method for Ewald sums in large systems

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21 January 2018

Zinc Binding to Alzheimer's Aβ(1–16) Peptide Results in Stable Soluble Complex

1 reference

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21 January 2018

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