(Q24657471)

1

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Rubén D Garcia-Ordoñez

2

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Todd P Logan

3

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Lilin Li

5

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Lael Reinstatler

6

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Malcolm A Leissring

Proceedings of the National Academy of Sciences of the United States of America

7

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language of work or name

English

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publication date

15 July 2008

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published in

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volume

105

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issue

28

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page(s)

9582-7

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cites work

Structure of substrate-free human insulin-degrading enzyme (IDE) and biophysical analysis of ATP-induced conformational switch of IDE

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2474492

Structures of human insulin-degrading enzyme reveal a new substrate recognition mechanism

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2474492

Alternative translation initiation generates a novel isoform of insulin-degrading enzyme targeted to mitochondria

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2474492

Insulin-degrading enzyme regulates the levels of insulin, amyloid beta-protein, and the beta-amyloid precursor protein intracellular domain in vivo

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2474492

A genome-wide association study identifies novel risk loci for type 2 diabetes

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2474492

Decreased catalytic activity of the insulin-degrading enzyme in chromosome 10-linked Alzheimer disease families

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2474492

The insulysin (insulin degrading enzyme) enigma

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2474492

Comparison of the enzymatic and biochemical properties of human insulin-degrading enzyme and Escherichia coli protease III

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2474492

Replication of genome-wide association signals in UK samples reveals risk loci for type 2 diabetes

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2474492

Mutation of active site residues of insulin-degrading enzyme alters allosteric interactions

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2474492

Neurons regulate extracellular levels of amyloid beta-protein via proteolysis by insulin-degrading enzyme

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2474492

A new model for vitamin K-dependent carboxylation: the catalytic base that deprotonates vitamin K hydroquinone is not Cys but an activated amine

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2474492

Clearance of Alzheimer's Abeta peptide: the many roads to perdition.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2474492

Partial loss-of-function mutations in insulin-degrading enzyme that induce diabetes also impair degradation of amyloid beta-protein

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2474492

Amyloid-beta peptide levels in brain are inversely correlated with insulysin activity levels in vivo

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2474492

Insulin-degrading enzyme identified as a candidate diabetes susceptibility gene in GK rats

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2474492

An unusual active site identified in a family of zinc metalloendopeptidases

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2474492

Isolation and characterization of an insulin-degrading enzyme from Drosophila melanogaster.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2474492

Susceptibility locus for Alzheimer's disease on chromosome 10.

30 May 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0801261105

Diabetes mellitus and the risk of dementia: The Rotterdam Study.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0801261105

Enhanced proteolysis of beta-amyloid in APP transgenic mice prevents plaque formation, secondary pathology, and premature death.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0801261105

Insulin degrading enzyme activity selectively decreases in the hippocampal formation of cases at high risk to develop Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0801261105

Age- and region-dependent alterations in Abeta-degrading enzymes: implications for Abeta-induced disorders

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0801261105

Alternative splicing of human insulin-degrading enzyme yields a novel isoform with a decreased ability to degrade insulin and amyloid beta-protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0801261105

Kinetics of amyloid beta-protein degradation determined by novel fluorescence- and fluorescence polarization-based assays

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0801261105

Susceptibility of amyloid beta peptide degrading enzymes to oxidative damage: a potential Alzheimer's disease spiral

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0801261105

Functional analysis of conserved residues in the active site of insulin-degrading enzyme.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2474492

Evidence for genetic linkage of Alzheimer's disease to chromosome 10q

28 November 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/18621727

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Linkage of plasma Abeta42 to a quantitative locus on chromosome 10 in late-onset Alzheimer's disease pedigrees

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/18621727

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Insulysin and pitrilysin: insulin-degrading enzymes of mammals and bacteria

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/18621727