(Q51722272)

10 April 2018

title

Discovery of highly soluble antibodies prior to purification using affinity-capture self-interaction nanoparticle spectroscopy. (English)

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8

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author name string

Jiemin Wu

1

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Jason S Schultz

2

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Caroline L Weldon

3

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Shantanu V Sule

4

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10 April 2018

Qing Chai

5

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Steven B Geng

6

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Craig D Dickinson

7

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publication date

12 September 2015

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10 April 2018

Protein Engineering Design and Selection

published in

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10 April 2018

volume

28

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issue

10

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page(s)

403-414

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High-throughput biophysical analysis and data visualization of conformational stability of an IgG1 monoclonal antibody after deglycosylation

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Reversible self-association increases the viscosity of a concentrated monoclonal antibody in aqueous solution

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High-throughput screening for developability during early-stage antibody discovery using self-interaction nanoparticle spectroscopy

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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Epitope mapping of anti-interleukin-13 neutralizing antibody CNTO607

21 January 2018

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Emerging methods for identifying monoclonal antibodies with low propensity to self-associate during the early discovery process.

21 January 2018

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21 January 2018

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Structure-based engineering of a monoclonal antibody for improved solubility

21 January 2018

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Addressing polyspecificity of antibodies selected from an in vitro yeast presentation system: a FACS-based, high-throughput selection and analytical tool

21 January 2018

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Establishing a link between amino acid sequences and self-associating and viscoelastic behavior of two closely related monoclonal antibodies

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FPROTEIN%2FGZV045

Application of a kosmotrope-based solubility assay to multiple protein therapeutic classes indicates broad use as a high-throughput screen for protein therapeutic aggregation propensity

21 January 2018

1 reference

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Evaluation of the aggregation states of monoclonal antibodies by diverse and complementary methods.

21 January 2018

1 reference

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21 January 2018

Identifiers

DOI

10.1093/PROTEIN/GZV045

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10 April 2018

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10 April 2018