(Q51753834)

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A targeted deletion/insertion in the mouse Pcsk1 locus is associated with homozygous embryo preimplantation lethality, mutant allele preferential transmission and heterozygous female susceptibility to dietary fat.

scientific article published in April 2007

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30 December 2019

A targeted deletion/insertion in the mouse Pcsk1 locus is associated with homozygous embryo preimplantation lethality, mutant allele preferential transmission and heterozygous female susceptibility to dietary fat (English)

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30 December 2019

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30 December 2019

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30 December 2019

Michel Chrétien

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30 December 2019

Gilles Croissandeau

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Gilles Croissandeau

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30 December 2019

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Janice Mayne

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30 December 2019

Francine Sirois

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Francine Sirois

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30 December 2019

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Younes Anini

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1 April 2007

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30 December 2019

Developmental Biology

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30 December 2019

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30 December 2019

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30 December 2019

584-598

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30 December 2019

MicroRNA functions in animal development and human disease

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7B2 is a specific intracellular binding protein of the prohormone convertase PC2

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Alpha1-antitrypsin Portland inhibits processing of precursors mediated by proprotein convertases primarily within the constitutive secretory pathway

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7B2 is a neuroendocrine chaperone that transiently interacts with prohormone convertase PC2 in the secretory pathway

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GnRH mRNA and protein expression in human preimplantation embryos.

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Quantitative neuropeptidomics of microwave-irradiated mouse brain and pituitary

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Chemistry and biosynthesis of pro-opiomelanocortin. ACTH, MSH's, endorphins and their related peptides

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Analysis of the expression of growth factor, interleukin-1, and lactoferrin genes and the distribution of inflammatory leukocytes in the preimplantation mouse oviduct

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Furin and prohormone convertase 1/3 are major convertases in the processing of mouse pro-growth hormone-releasing hormone

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Temporal pattern of IGF-I expression during mouse preimplantation embryogenesis.

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Inhibitory effect of IGF-I on induced apoptosis in mouse preimplantation embryos cultured in vitro.

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Identification and characterization of proSAAS, a granin-like neuroendocrine peptide precursor that inhibits prohormone processing

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Gene organization of the mouse pro-hormone and pro-protein convertase PC1.

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Inhibitory potency and specificity of subtilase-like pro-protein convertase (SPC) prodomains

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Detection of specific polymerase chain reaction product by utilizing the 5'----3' exonuclease activity of Thermus aquaticus DNA polymerase

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Obesity and impaired prohormone processing associated with mutations in the human prohormone convertase 1 gene

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Small-intestinal dysfunction accompanies the complex endocrinopathy of human proprotein convertase 1 deficiency

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Insulin-like growth factor-I as a survival factor for the bovine preimplantation embryo exposed to heat shock

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Two activation states of the prohormone convertase PC1 in the secretory pathway

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A predicted alpha -helix mediates targeting of the proprotein convertase PC1 to the regulated secretory pathway

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Gonadotropin-releasing hormone I analog acts as an antiapoptotic factor in mouse blastocysts

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Immunocytochemical localization of prohormone convertases PC1 and PC2 in the mouse thyroid gland and respiratory tract

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Culture of preimplantation embryos

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Prohormone convertase 1 (PC1) processing and sorting: effect of PC1 propeptide and proSAAS.

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Expression of mRNA for the insulin-like growth factors and their receptors in human preimplantation embryos.

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Obesity, hyperphagia and increased metabolic efficiency in Pc1 mutant mice

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Transmission Ratio Distortion in Mice

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Electron microscopic immunocytochemical evidence for the involvement of the convertases PC1 and PC2 in the processing of proinsulin in pancreatic beta-cells

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Ontogeny of the prohormone convertases PC1 and PC2 in the mouse hypophysis and their colocalization with corticotropin and alpha-melanotropin

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Impaired fertility in mice deficient for the testicular germ-cell protease PC4

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