(Q51905139)

17 April 2018

title

Physiologically based pharmacokinetic modelling: a sub-compartmentalized model of tissue distribution. (English)

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17 April 2018

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1

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17 April 2018

author name string

Wilhelm Huisinga

series ordinal

2

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17 April 2018

publication date

25 September 2007

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17 April 2018

Journal of Pharmacokinetics and Pharmacodynamics

published in

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17 April 2018

volume

34

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17 April 2018

issue

6

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17 April 2018

page(s)

789-806

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17 April 2018

https://scigraph.springernature.com/pub.10.1007/s10928-007-9071-3

exact match

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cites work

Physiological parameter values for physiologically based pharmacokinetic models

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Lumping of whole-body physiologically based pharmacokinetic models

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Physiologically Based Pharmacokinetic Modeling

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Prediction of adipose tissue: plasma partition coefficients for structurally unrelated drugs

21 January 2018

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12 December 2020

ADMET in silico modelling: towards prediction paradise?

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A physiologically based pharmacokinetic model of zidovudine (AZT) in the mouse: model development and scale-up to humans

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Prediction of pharmacokinetics prior to in vivo studies. II. Generic physiologically based pharmacokinetic models of drug disposition

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Human extrahepatic cytochromes P450: function in xenobiotic metabolism and tissue-selective chemical toxicity in the respiratory and gastrointestinal tracts

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Physiologically-based pharmacokinetic simulation modelling.

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A priori prediction of tissue:plasma partition coefficients of drugs to facilitate the use of physiologically-based pharmacokinetic models in drug discovery.

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An evaluation of the utility of physiologically based models of pharmacokinetics in early drug discovery.

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Prediction of pharmacokinetics prior to in vivo studies. 1. Mechanism-based prediction of volume of distribution.

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Utility of physiologically based pharmacokinetic models to drug development and rational drug discovery candidate selection.

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Can the pharmaceutical industry reduce attrition rates?

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Physiologically based pharmacokinetic modelling 2: predicting the tissue distribution of acids, very weak bases, neutrals and zwitterions.

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Volume of distribution at steady state for a linear pharmacokinetic system with peripheral elimination

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Lumping in pharmacokinetics.

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Tissue distribution and pharmacodynamics: a complicated relationship

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A novel strategy for physiologically based predictions of human pharmacokinetics

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Physiologically Based Pharmacokinetic Modeling: Principles and Applications

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Physiologically based pharmacokinetic modeling 1: predicting the tissue distribution of moderate-to-strong bases.

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From physicochemistry to absorption and distribution: predictive mechanistic modelling and computational tools

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Red blood cells: a neglected compartment in pharmacokinetics and pharmacodynamics.

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Mechanistic approaches to volume of distribution predictions: understanding the processes.

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Development and application of physiologically based pharmacokinetic-modeling tools to support drug discovery.

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Physiologically based pharmacokinetics of drug-drug interaction: a study of tolbutamide-sulfonamide interaction in rats.

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Physiologically based pharmacokinetics of cyclosporine A: extension to tissue distribution kinetics in rats and scale-up to human

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Development of physiologically based pharmacokinetic and physiologically based pharmacodynamic models for applications in toxicology and risk assessment.

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12 December 2020

10.1007/S10928-007-9071-3

Identifiers

DOI

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17 April 2018

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17 April 2018