(Q52039310)

20 April 2018

review article

1 reference

title

The roles of antibody variable region hypermutation and selection in the development of the memory B-cell compartment. (English)

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20 April 2018

author name string

Manser T

1

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20 April 2018

Tumas-Brundage KM

2

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20 April 2018

Casson LP

3

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20 April 2018

Giusti AM

4

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20 April 2018

Hande S

5

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20 April 2018

Notidis E

6

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20 April 2018

Vora KA

7

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20 April 2018

publication date

1 April 1998

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20 April 2018

published in

Immunological Reviews

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20 April 2018

volume

162

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20 April 2018

page(s)

183-196

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20 April 2018

Somatic hypermutation of an immunoglobulin transgene in kappa transgenic mice

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Hypermutation is observed only in antibody H chain V region transgenes that have recombined with endogenous immunoglobulin H DNA: implications for the location of cis-acting elements required for somatic mutation

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21 January 2018

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Boundaries of somatic mutation in rearranged immunoglobulin genes: 5' boundary is near the promoter, and 3' boundary is approximately 1 kb from V(D)J gene

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The transcriptional promoter regulates hypermutation of the antibody heavy chain locus

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B lymphocytes of xeroderma pigmentosum or Cockayne syndrome patients with inherited defects in nucleotide excision repair are fully capable of somatic hypermutation of immunoglobulin genes

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In situ studies of the primary immune response to (4-hydroxy-3-nitrophenyl)acetyl. I. The architecture and dynamics of responding cell populations

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Germinal centres in T-cell-dependent antibody responses

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The maturation of the immune response

21 January 2018

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B-cell memory is short-lived in the absence of antigen.

21 January 2018

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Somatically mutated forms of a major anti-p-azophenylarsonate antibody variable region with drastically reduced affinity for p-azophenylarsonate. By-products of an antigen-driven immune response?

21 January 2018

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In situ studies of the primary immune response to (4-hydroxy-3-nitrophenyl)acetyl. III. The kinetics of V region mutation and selection in germinal center B cells

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Generation and analysis of random point mutations in an antibody CDR2 sequence: many mutated antibodies lose their ability to bind antigen

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Analysis of somatic mutation and class switching in naive and memory B cells generating adoptive primary and secondary responses

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Molecular analysis of original antigenic sin. I. Clonal selection, somatic mutation, and isotype switching during a memory B cell response

21 January 2018

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Intraclonal generation of antibody mutants in germinal centres

21 January 2018

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Maturation of the immune response in germinal centers

21 January 2018

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Cyclic re-entry of germinal center B cells and the efficiency of affinity maturation

21 January 2018

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Different epitope structures select distinct mutant forms of an antibody variable region for expression during the immune response

21 January 2018

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The natural autoantibodies system: between hypotheses and facts

21 January 2018

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A single germline VH gene segment of normal A/J mice encodes autoantibodies characteristic of systemic lupus erythematosus

21 January 2018

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Evolution of antibody structure during the immune response. The differentiative potential of a single B lymphocyte

21 January 2018

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Inter- and intraclonal diversity in the antibody response to influenza hemagglutinin

21 January 2018

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Immunological tolerance in germinal centres

21 January 2018

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Random mutagenesis of two complementarity determining region amino acids yields an unexpectedly high frequency of antibodies with increased affinity for both cognate antigen and autoantigen

21 January 2018

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The role of germline gene expression and somatic mutation in the generation of autoantibodies to DNA.

21 January 2018

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bcl-2-immunoglobulin transgenic mice demonstrate extended B cell survival and follicular lymphoproliferation

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1600-065X.1998.TB01441.X

bcl-2 inhibits multiple forms of apoptosis but not negative selection in thymocytes

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1600-065X.1998.TB01441.X

The bcl-2 gene product inhibits clonal deletion of self-reactive B lymphocytes in the periphery but not in the bone marrow

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.1998.TB01441.X

Differentiation of B cells in the nonlymphoid tissue of the synovial membrane of patients with rheumatoid arthritis

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.1998.TB01441.X

In situ studies of the primary immune response to (4-hydroxy-3-nitrophenyl)acetyl. IV. Affinity-dependent, antigen-driven B cell apoptosis in germinal centers as a mechanism for maintaining self-tolerance

21 January 2018

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Soluble antigen can cause enhanced apoptosis of germinal-centre B cells.

21 January 2018

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Antigen-induced B-cell death and elimination during germinal-centre immune responses

21 January 2018

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CD95 (Fas)-dependent elimination of self-reactive B cells upon interaction with CD4+T cells

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1600-065X.1998.TB01441.X

Protection against Fas-dependent Th1-mediated apoptosis by antigen receptor engagement in B cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.1998.TB01441.X

Human germinal center B cells express the apoptosis-inducing genes Fas, c-myc, P53, and Bax but not the survival gene bcl-2

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.1998.TB01441.X

Pathogenic autoantibodies are routinely generated during the response to foreign antigen: a paradigm for autoimmune disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.1998.TB01441.X

Elements regulating somatic hypermutation of an immunoglobulin κ gene: Critical role for the intron enhancer/matrix attachment region

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.1998.TB01441.X

Somatic hypermutation of immunoglobulin genes is linked to transcription initiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.1998.TB01441.X

Evaluation of the role of the 3'alpha heavy chain enhancer [3'alpha E(hs1,2)] in Vh gene somatic hypermutation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.1998.TB01441.X

Autoantibodies and the physiological role of immunoglobulins

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.1998.TB01441.X

A substantial proportion of the adult BALB/c available B cell repertoire consists of multireactive B cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.1998.TB01441.X

Anatomy of autoantibody production: Dominant localization of antibody-producing cells to T cell zones in fas-deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.1998.TB01441.X

Selection under a somatic model

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.1998.TB01441.X

10.1111/J.1600-065X.1998.TB01441.X

21 January 2018

Identifiers

DOI

1 reference

20 April 2018

1 reference

20 April 2018