(Q52093756)

22 April 2018

title

Duration of TCR signaling controls CD4-CD8 lineage differentiation in vivo (English)

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22 April 2018

author name string

Xiaolong Liu

series ordinal

1

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22 April 2018

Rémy Bosselut

series ordinal

2

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22 April 2018

language of work or name

English

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publication date

8 February 2004

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22 April 2018

published in

Nature Immunology

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22 April 2018

volume

5

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22 April 2018

issue

3

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22 April 2018

page(s)

280-288

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22 April 2018

Signals and signs for lymphocyte responses

cites work

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Signal transduction by lymphocyte antigen receptors

21 January 2018

1 reference

Differential requirements for Runx proteins in CD4 repression and epigenetic silencing during T lymphocyte development

21 January 2018

1 reference

Signal strength in thymic selection and lineage commitment.

21 January 2018

1 reference

New perspectives on a developmental dilemma: the kinetic signaling model and the importance of signal duration for the CD4/CD8 lineage decision

21 January 2018

1 reference

T-cell development and the CD4-CD8 lineage decision

21 January 2018

1 reference

The cytoplasmic domain of CD4 promotes the development of CD4 lineage T cells

21 January 2018

1 reference

MHC class II-specific T cells can develop in the CD8 lineage when CD4 is absent

21 January 2018

1 reference

The Influence of the MAPK Pathway on T Cell Lineage Commitment

21 January 2018

1 reference

Signals through CD8 or CD4 can induce commitment to the CD4 lineage in the thymus

21 January 2018

1 reference

Lck activity controls CD4/CD8 T cell lineage commitment.

21 January 2018

1 reference

Requirement for sustained MAPK signaling in both CD4 and CD8 lineage commitment: a threshold model

21 January 2018

1 reference

Defective T-cell receptor signalling and positive selection of Vav-deficient CD4+ CD8+ thymocytes

21 January 2018

1 reference

Defective antigen receptor-mediated proliferation of B and T cells in the absence of Vav.

21 January 2018

1 reference

Defective signalling through the T- and B-cell antigen receptors in lymphoid cells lacking the vav proto-oncogene

21 January 2018

1 reference

Requirement for p56lck tyrosine kinase activation in T cell receptor-mediated thymic selection

21 January 2018

1 reference

Role of the multiple T cell receptor (TCR)-zeta chain signaling motifs in selection of the T cell repertoire

21 January 2018

1 reference

The duration of antigen receptor signalling determines CD4+ versus CD8+ T-cell lineage fate

21 January 2018

1 reference

Unraveling a revealing paradox: Why major histocompatibility complex I-signaled thymocytes "paradoxically" appear as CD4+8lo transitional cells during positive selection of CD8+ T cells

21 January 2018

1 reference

ZAP-70: a 70 kd protein-tyrosine kinase that associates with the TCR zeta chain

21 January 2018

1 reference

Sequential interactions of the TCR with two distinct cytoplasmic tyrosine kinases

21 January 2018

1 reference

Essential role for ZAP-70 in both positive and negative selection of thymocytes

21 January 2018

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Restricting Zap70 expression to CD4+CD8+ thymocytes reveals a T cell receptor-dependent proofreading mechanism controlling the completion of positive selection

21 January 2018

1 reference

Evidence for a complex regulatory array in the first intron of the human adenosine deaminase gene

21 January 2018

1 reference

Intermediate steps in positive selection: differentiation of CD4+8int TCRint thymocytes into CD4-8+TCRhi thymocytes

21 January 2018

1 reference

Asymmetric signaling requirements for thymocyte commitment to the CD4+ versus CD8+ T cell lineages: a new perspective on thymic commitment and selection

21 January 2018

1 reference

CD69 expression during selection and maturation of CD4+8+ thymocytes.

21 January 2018

1 reference

Peptide-induced positive selection of TCR transgenic thymocytes in a coreceptor-independent manner.

21 January 2018

1 reference

Runx3 and Runx1 are required for CD8 T cell development during thymopoiesis

21 January 2018

1 reference

GATA-3 expression is controlled by TCR signals and regulates CD4/CD8 differentiation

21 January 2018

1 reference

Critical roles for transcription factor GATA-3 in thymocyte development

21 January 2018

1 reference

Unexpectedly complex regulation of CD4/CD8 coreceptor expression supports a revised model for CD4+CD8+ thymocyte differentiation.

21 January 2018

1 reference

Positive selection as a developmental progression initiated by alpha beta TCR signals that fix TCR specificity prior to lineage commitment

21 January 2018

1 reference

TCR signaling for initiation and completion of thymocyte positive selection has distinct requirements for ligand quality and presenting cell type.

21 January 2018

1 reference

Selective development of CD4+ T cells in transgenic mice expressing a class II MHC-restricted antigen receptor

21 January 2018

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bcl-2 inhibits multiple forms of apoptosis but not negative selection in thymocytes

21 January 2018

1 reference

CD5 expression is developmentally regulated by T cell receptor (TCR) signals and TCR avidity

21 January 2018

1 reference

Protein kinase B regulates T lymphocyte survival, nuclear factor kappaB activation, and Bcl-X(L) levels in vivo

21 January 2018

1 reference

Signal transduction mediated by the T cell antigen receptor: the role of adapter proteins

21 January 2018

1 reference

Fine tuning of TCR signaling by CD5.

21 January 2018

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The Src-like adaptor protein downregulates the T cell receptor on CD4+CD8+ thymocytes and regulates positive selection.

21 January 2018

1 reference

Abnormal differentiation of thymocytes in mice treated with cyclosporin A.

21 January 2018

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CD8 is needed for development of cytotoxic T cells but not helper T cells

21 January 2018

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Csk controls antigen receptor-mediated development and selection of T-lineage cells.

21 January 2018

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Activated p56lck directs maturation of both CD4 and CD8 single-positive thymocytes

21 January 2018

1 reference

In vitro evidence that cytokine receptor signals are required for differentiation of double positive thymocytes into functionally mature CD8+ T cells

21 January 2018

1 reference

Suppressor of cytokine signaling-1 is a critical regulator of interleukin-7-dependent CD8+ T cell differentiation.

21 January 2018

1 reference

An influence of CD5 on the selection of CD4-lineage T cells

21 January 2018

1 reference

TOX: an HMG box protein implicated in the regulation of thymocyte selection

21 January 2018

1 reference

Evidence for a stochastic mechanism in the differentiation of mature subsets of T lymphocytes.

21 January 2018

1 reference

A human CD4 transgene rescues CD4-CD8+ cells in beta 2-microglobulin-deficient mice

21 January 2018

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Deletion of the CD4 silencer element supports a stochastic mechanism of thymocyte lineage commitment

21 January 2018

1 reference

Beta 2-microglobulin deficient mice lack CD4-8+ cytolytic T cells.

21 January 2018

1 reference

A role for CD5 in TCR-mediated signal transduction and thymocyte selection

21 January 2018

1 reference

Role of TCR zeta chain in T cell development and selection

21 January 2018

1 reference

7 January 2021

A Requirement for the Rho-Family GTP Exchange Factor Vav in Positive and Negative Selection of Thymocytes

1 reference

7 January 2021

Coreceptor reversal in the thymus: signaled CD4+8+ thymocytes initially terminate CD8 transcription even when differentiating into CD8+ T cells

1 reference

7 January 2021

Programming for cytotoxic effector function occurs concomitantly with CD4 extinction during CD8(+) T cell differentiation in the thymus

1 reference

7 January 2021

Bcl-2 is upregulated at the CD4+ CD8+ stage during positive selection and promotes thymocyte differentiation at several control points

1 reference

7 January 2021

Strength of signaling by CD4 and CD8 coreceptor tails determines the number but not the lineage direction of positively selected thymocytes

1 reference

7 January 2021

Identifiers

DOI

10.1038/NI1040

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22 April 2018

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22 April 2018