(Q52112319)

22 April 2018

title

The adaptor protein SLP-65 acts as a tumor suppressor that limits pre-B cell expansion. (English)

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22 April 2018

Tilman Brummer

2

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author name string

Alexandra Flemming

series ordinal

1

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22 April 2018

Michael Reth

series ordinal

3

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22 April 2018

Hassan Jumaa

series ordinal

4

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22 April 2018

language of work or name

English

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publication date

18 November 2002

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22 April 2018

published in

Nature Immunology

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22 April 2018

volume

4

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22 April 2018

page(s)

38-43

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22 April 2018

issue

1

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22 April 2018

https://scigraph.springernature.com/pub.10.1038/ni862

exact match

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cites work

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Defects in early B-cell development: comparing the consequences of abnormalities in pre-BCR signaling in the human and the mouse

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Precursor B cells showing H chain allelic inclusion display allelic exclusion at the level of pre-B cell receptor surface expression

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A B cell-deficient mouse by targeted disruption of the membrane exon of the immunoglobulin mu chain gene

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A critical role of λ5 protein in B cell development

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Loss of precursor B cell expansion but not allelic exclusion in VpreB1/VpreB2 double-deficient mice

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Regulation of B cell function by linker proteins

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Adapter proteins in lymphocyte antigen-receptor signaling

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Lymphocytes with a complex: adapter proteins in antigen receptor signaling

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7 January 2021

Impaired viability and profound block in thymocyte development in mice lacking the adaptor protein SLP-76.

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Requirement for the leukocyte-specific adapter protein SLP-76 for normal T cell development.

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7 January 2021

Essential role of LAT in T cell development

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7 January 2021

SLP-65: a new signaling component in B lymphocytes which requires expression of the antigen receptor for phosphorylation

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7 January 2021

BLNK: a central linker protein in B cell activation

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7 January 2021

Interaction of SLP adaptors with the SH2 domain of Tec family kinases

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7 January 2021

BLNK required for coupling Syk to PLC gamma 2 and Rac1-JNK in B cells

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7 January 2021

Regulation of the phospholipase C-gamma2 pathway in B cells

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7 January 2021

Abnormal development and function of B lymphocytes in mice deficient for the signaling adaptor protein SLP-65

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7 January 2021

Requirement for B cell linker protein (BLNK) in B cell development

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7 January 2021

The B cell-restricted adaptor BASH is required for normal development and antigen receptor-mediated activation of B cells

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7 January 2021

B cell development and activation defects resulting in xid-like immunodeficiency in BLNK/SLP-65-deficient mice

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7 January 2021

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7 January 2021

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Down-regulation of RAG1 and RAG2 gene expression in preB cells after functional immunoglobulin heavy chain rearrangement

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Enhanced transgene expression in primitive hematopoietic progenitor cells and embryonic stem cells efficiently transduced by optimized retroviral hybrid vectors.

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7 January 2021

Rel/NF-kappaB transcription factors: key mediators of B-cell activation

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7 January 2021

The adaptor protein BLNK is required for b cell antigen receptor-induced activation of nuclear factor-kappa B and cell cycle entry and survival of B lymphocytes

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7 January 2021

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1 reference

7 January 2021

Activated Ras signals developmental progression of recombinase-activating gene (RAG)-deficient pro-B lymphocytes

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Ras mediates effector pathways responsible for pre-B cell survival, which is essential for the developmental progression to the late pre-B cell stage

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7 January 2021

Pre-B cell receptor signaling mediates selective response to IL-7 at the pro-B to pre-B cell transition via an ERK/MAP kinase-dependent pathway

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7 January 2021

The splicing factor SRp20 modifies splicing of its own mRNA and ASF/SF2 antagonizes this regulation

1 reference

7 January 2021

Identifiers

DOI

10.1038/NI862

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22 April 2018

Dimensions Publication ID

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22 April 2018