(Q52162415)

25 April 2018

title

The cryo-electron microscopy structure of huntingtin (English)

1 reference

25 April 2018

cryogenic electron microscopy

main subject

0 references

Qiang Guo

1

0 references

Patrick Oeckl

object named as

Patrick Oeckl

Rubén Fernández-Busnadiego

7

0 references

13

object named as

Rubén Fernández-Busnadiego

1 reference

25 April 2018

8

Markus Otto

1 reference

25 April 2018

author name string

Bin Huang

2

1 reference

25 April 2018

Jingdong Cheng

3

1 reference

25 April 2018

Manuel Seefelder

4

1 reference

25 April 2018

Tatjana Engler

5

1 reference

25 April 2018

Günter Pfeifer

6

1 reference

25 April 2018

Franziska Moser

9

1 reference

25 April 2018

Melanie Maurer

10

1 reference

25 April 2018

Alexander Pautsch

11

1 reference

25 April 2018

Wolfgang Baumeister

12

1 reference

25 April 2018

Stefan Kochanek

14

1 reference

25 April 2018

language of work or name

English

0 references

publication date

21 February 2018

1 reference

25 April 2018

published in

Nature

1 reference

25 April 2018

volume

555

1 reference

25 April 2018

issue

7694

1 reference

25 April 2018

page(s)

117-120

1 reference

25 April 2018

Post-Translational Modifications (PTMs), Identified on Endogenous Huntingtin, Cluster within Proteolytic Domains between HEAT Repeats

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5837020

High-resolution Single Particle Analysis from Electron Cryo-microscopy Images Using SPHIRE

25 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5837020

MotionCor2: anisotropic correction of beam-induced motion for improved cryo-electron microscopy

25 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5837020

Huntingtin's spherical solenoid structure enables polyglutamine tract-dependent modulation of its structure and function

25 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5837020

The Biology of Huntingtin.

25 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5837020

CTFFIND4: Fast and accurate defocus estimation from electron micrographs.

25 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5837020

ProteoPlex: stability optimization of macromolecular complexes by sparse-matrix screening of chemical space

25 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5837020

Huntingtin proteolysis releases non-polyQ fragments that cause toxicity through dynamin 1 dysregulation.

25 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5837020

Scalable production in human cells and biochemical characterization of full-length normal and mutant huntingtin

25 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5837020

The emerging role of the first 17 amino acids of huntingtin in Huntington's disease

25 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5837020

Scalable web services for the PSIPRED Protein Analysis Workbench.

25 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5837020

RELION: implementation of a Bayesian approach to cryo-EM structure determination

25 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5837020

Prevention of overfitting in cryo-EM structure determination

25 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5837020

Network organization of the huntingtin proteomic interactome in mammalian brain

25 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5837020

PHENIX: a comprehensive Python-based system for macromolecular structure solution

25 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5837020

MolProbity: all-atom structure validation for macromolecular crystallography

25 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5837020

Huntingtin facilitates polycomb repressive complex 2.

25 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5837020

Detection of alpha-rod protein repeats using a neural network and application to huntingtin.

25 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5837020

Mutant huntingtin N-terminal fragments of specific size mediate aggregation and toxicity in neuronal cells

25 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5837020

Phylogenetic comparison of huntingtin homologues reveals the appearance of a primitive polyQ in sea urchin

25 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5837020

Huntingtin interacting proteins are genetic modifiers of neurodegeneration

25 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5837020

Chemical screening methods to identify ligands that promote protein stability, protein crystallization, and structure determination

25 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5837020

Huntingtin phosphorylation sites mapped by mass spectrometry. Modulation of cleavage and toxicity

25 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5837020

Palmitoylation of huntingtin by HIP14 is essential for its trafficking and function

25 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5837020

Expression and characterization of full-length human huntingtin, an elongated HEAT repeat protein

25 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5837020

Huntingtin-HAP40 complex is a novel Rab5 effector that regulates early endosome motility and is up-regulated in Huntington's disease

25 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5837020

Automated electron microscope tomography using robust prediction of specimen movements

25 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5837020

Huntingtin associates with acidic phospholipids at the plasma membrane

25 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5837020

Cdk5 phosphorylation of huntingtin reduces its cleavage by caspases: implications for mutant huntingtin toxicity

25 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5837020

Coot: model-building tools for molecular graphics

25 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5837020

UCSF Chimera--a visualization system for exploratory research and analysis

25 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5837020

The predominantly HEAT-like motif structure of huntingtin and its association and coincident nuclear entry with dorsal, an NF-kB/Rel/dorsal family transcription factor

25 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5837020

Isolation of a 40-kDa Huntingtin-associated protein

25 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5837020

Huntingtin: a single bait hooks many species

25 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5837020

Caspase cleavage of gene products associated with triplet expansion disorders generates truncated fragments containing the polyglutamine tract

25 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5837020

A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes.

25 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5837020

HEAT repeats in the Huntington's disease protein

25 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5837020

25 August 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE25502

inferred from DOI database lookup

7 January 2021

based on heuristic

Identifiers

DOI

10.1038/NATURE25502

1 reference

25 April 2018

Dimensions Publication ID

1101139800

0 references

PMC publication ID

5837020

0 references

1 reference

25 April 2018