(Q52181530)

26 April 2018

review article

1 reference

title

Thymocyte selection: not by TCR alone. (English)

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26 April 2018

0 references

Amsen D

1

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26 April 2018

Kruisbeek AM

series ordinal

2

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26 April 2018

publication date

1 October 1998

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26 April 2018

published in

Immunological Reviews

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26 April 2018

volume

165

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26 April 2018

page(s)

209-229

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26 April 2018

In thymic selection, peptide diversity gives and takes away

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Negative selection in the thymus includes semimature T cells

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The MHC reactivity of the T cell repertoire prior to positive and negative selection.

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T cell receptor antagonist peptides induce positive selection

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A TCR binds to antagonist ligands with lower affinities and faster dissociation rates than to agonists

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Specific recognition of thymic self-peptides induces the positive selection of cytotoxic T lymphocytes

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The repertoire of T cells shaped by a single MHC/peptide ligand.

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Thymic selection by a single MHC/peptide ligand produces a semidiverse repertoire of CD4+ T cells.

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Two human T cell receptors bind in a similar diagonal mode to the HLA-A2/Tax peptide complex using different TCR amino acids

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Differential signaling by lymphocyte antigen receptors.

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ZAP-70 is constitutively associated with tyrosine-phosphorylated TCR ζ in murine thymocytes and lymph node T cells

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Lck regulates the tyrosine phosphorylation of the T cell receptor subunits and ZAP-70 in murine thymocytes

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Signaling checkpoints during the development of T lymphocytes

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Essential role for ZAP-70 in both positive and negative selection of thymocytes

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Requirement for p56lck tyrosine kinase activation in T cell receptor-mediated thymic selection

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Interactions of p59fyn and ZAP-70 with T-cell receptor activation motifs: defining the nature of a signalling motif

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Defective T cell receptor signaling in mice lacking the thymic isoform of p59fyn

21 January 2018

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CD45-null transgenic mice reveal a positive regulatory role for CD45 in early thymocyte development, in the selection of CD4+CD8+ thymocytes, and B cell maturation

21 January 2018

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Qualitative and quantitative contributions of the T cell receptor zeta chain to mature T cell apoptosis

21 January 2018

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Role of the multiple T cell receptor (TCR)-zeta chain signaling motifs in selection of the T cell repertoire

21 January 2018

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The single positive T cells found in CD3-zeta/eta-/- mice overtly react with self-major histocompatibility complex molecules upon restoration of normal surface density of T cell receptor-CD3 complex

21 January 2018

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CD3 delta deficiency arrests development of the alpha beta but not the gamma delta T cell lineage

21 January 2018

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The CD3gamma chain is essential for development of both the TCRalphabeta and TCRgammadelta lineages

21 January 2018

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Adaptor proteins in lymphocyte antigen-receptor signaling

21 January 2018

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Signal transduction. How receptors turn Ras on.

21 January 2018

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Defective antigen receptor-mediated proliferation of B and T cells in the absence of Vav.

21 January 2018

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Defective T-cell receptor signalling and positive selection of Vav-deficient CD4+ CD8+ thymocytes

21 January 2018

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Phosphotyrosine-dependent activation of Rac-1 GDP/GTP exchange by the vav proto-oncogene product

21 January 2018

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Optic flow: A brain region devoted to optic flow analysis?

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1600-065X.1998.TB01241.X

Defects in actin-cap formation in Vav-deficient mice implicate an actin requirement for lymphocyte signal transduction

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1600-065X.1998.TB01241.X

LAT: the ZAP-70 tyrosine kinase substrate that links T cell receptor to cellular activation

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1600-065X.1998.TB01241.X

Lck phosphorylates the activation loop tyrosine of the Itk kinase domain and activates Itk kinase activity

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1600-065X.1998.TB01241.X

Expression of the chlI, chlD, and chlH genes from the Cyanobacterium synechocystis PCC6803 in Escherichia coli and demonstration that the three cognate proteins are required for magnesium-protoporphyrin chelatase activity

21 January 2018

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T cell receptor-initiated calcium release is uncoupled from capacitative calcium entry in Itk-deficient T cells

21 January 2018

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Altered T cell receptor signaling and disrupted T cell development in mice lacking Itk.

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1600-065X.1998.TB01241.X

Intracellular signals that mediate thymic negative selection

21 January 2018

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Differential activation of transcription factors induced by Ca2+ response amplitude and duration

21 January 2018

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Identification of calcineurin as a key signalling enzyme in T-lymphocyte activation

21 January 2018

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T cell receptor-mediated signaling events in CD4+CD8+ thymocytes undergoing thymic selection: requirement of calcineurin activation for thymic positive selection but not negative selection.

21 January 2018

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Abnormal differentiation of thymocytes in mice treated with cyclosporin A.

21 January 2018

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T cell responses in calcineurin A alpha-deficient mice

21 January 2018

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GTPases in antigen receptor signalling

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.1998.TB01241.X

T cell antigen receptor signal transduction pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.1998.TB01241.X

Transcriptional regulation by extracellular signals: mechanisms and specificity

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.1998.TB01241.X

Selective requirement for MAP kinase activation in thymocyte differentiation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.1998.TB01241.X

Positive and negative selection invoke distinct signaling pathways.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.1998.TB01241.X

Mitogen-activated protein kinase cascades and regulation of gene expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.1998.TB01241.X

JNK is involved in signal integration during costimulation of T lymphocytes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.1998.TB01241.X

Impaired CD28-mediated interleukin 2 production and proliferation in stress kinase SAPK/ERK1 kinase (SEK1)/mitogen-activated protein kinase kinase 4 (MKK4)-deficient T lymphocytes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.1998.TB01241.X

Transcription factors of the NFAT family: regulation and function

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.1998.TB01241.X

Hyperproliferation and dysregulation of IL-4 expression in NF-ATp-deficient mice

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1600-065X.1998.TB01241.X

Regulation of AP-1 and NFAT transcription factors during thymic selection of T cells

21 January 2018

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NF-kappa B: ten years after

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1600-065X.1998.TB01241.X

Targeted disruption of the p50 subunit of NF-kappa B leads to multifocal defects in immune responses

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1600-065X.1998.TB01241.X

Embryonic lethality and liver degeneration in mice lacking the RelA component of NF-κB

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.1998.TB01241.X

Nuclear factor (NF)-kappa B2 (p100/p52) is required for normal splenic microarchitecture and B cell-mediated immune responses

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.1998.TB01241.X

Perturbation of the T lymphocyte lineage in transgenic mice expressing a constitutive repressor of nuclear factor (NF)-kappaB.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.1998.TB01241.X

Expression of relB is required for the development of thymic medulla and dendritic cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.1998.TB01241.X

A role for the orphan steroid receptor Nur77 in apoptosis accompanying antigen-induced negative selection

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.1998.TB01241.X

Inhibition of Nur77/Nurr1 leads to inefficient clonal deletion of self-reactive T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.1998.TB01241.X

Functional redundancy of the Nur77 and Nor-1 orphan steroid receptors in T-cell apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.1998.TB01241.X

Apoptosis of nur77/N10-transgenic thymocytes involves the Fas/Fas ligand pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.1998.TB01241.X

Apoptosis by death factor

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.1998.TB01241.X

A dominant interfering mutant of FADD/MORT1 enhances deletion of autoreactive thymocytes and inhibits proliferation of mature T lymphocytes

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1600-065X.1998.TB01241.X

A role for FADD in T cell activation and development

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1600-065X.1998.TB01241.X

Fas-mediated apoptosis and activation-induced T-cell proliferation are defective in mice lacking FADD/Mort1

21 January 2018

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Daxx, a novel Fas-binding protein that activates JNK and apoptosis

21 January 2018

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RIP: a novel protein containing a death domain that interacts with Fas/APO-1 (CD95) in yeast and causes cell death

21 January 2018

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RAIDD is a new 'death' adaptor molecule

21 January 2018

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Positive selection of CD4+ T cells mediated by MHC class II-bearing stromal cell in the thymic cortex.

21 January 2018

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Positive selection of the T cell repertoire: where and when does it occur?

21 January 2018

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Antigen/MHC-specific T cells are preferentially exported from the thymus in the presence of their MHC ligand.

21 January 2018

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Targeted expression of major histocompatibility complex (MHC) class II molecules demonstrates that dendritic cells can induce negative but not positive selection of thymocytes in vivo

21 January 2018

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Inefficient positive selection of T cells directed by haematopoietic cells

21 January 2018

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Positive selection of T lymphocytes on fibroblasts

21 January 2018

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A cell line that can induce thymocyte positive selection

21 January 2018

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Positive selection of T-lymphocytes induced by intrathymic injection of a thymic epithelial cell line

21 January 2018

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Thymic epithelial cells provide unique signals for positive selection of CD4+CD8+ thymocytes in vitro

21 January 2018

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Bone marrow-derived cells fail to induce positive selection in thymus reaggregation cultures

21 January 2018

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Studies on T cell maturation on defined thymic stromal cell populations in vitro

21 January 2018

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Thymus epithelium induces tissue-specific tolerance

21 January 2018

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Clonal deletion induced by either radioresistant thymic host cells or lymphohemopoietic donor cells at different stages of class I-restricted T cell ontogeny

21 January 2018

1 reference

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Tolerance in T-cell-receptor transgenic mice involves deletion of nonmature CD4+8+ thymocytes

21 January 2018

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A role for Fas in negative selection of thymocytes in vivo

21 January 2018

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Antigen compartmentation and T helper cell tolerance induction

21 January 2018

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The level of CD8 expression can determine the outcome of thymic selection

21 January 2018

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CD8 surface levels alter the fate of alpha/beta T cell receptor-expressing thymocytes in transgenic mice

21 January 2018

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Thymocytes in Thy-1-/- mice show augmented TCR signaling and impaired differentiation

21 January 2018

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Protection from anti-TCR/CD3-induced apoptosis in immature thymocytes by a signal through thymic shared antigen-1/stem cell antigen-2

21 January 2018

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Negative selection of CD4+CD8+ thymocytes by T cell receptor-induced apoptosis requires a costimulatory signal that can be provided by CD28

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.1998.TB01241.X

Differing roles for B7 and intercellular adhesion molecule-1 in negative selection of thymocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.1998.TB01241.X

T cell receptor (TCR)-induced death of immature CD4+CD8+ thymocytes by two distinct mechanisms differing in their requirement for CD28 costimulation: implications for negative selection in the thymus

21 January 2018

1 reference

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Rescue of thymocytes from glucocorticoid-induced cell death mediated by CD28/CTLA-4 costimulatory interactions with B7-1/B7-2

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.1998.TB01241.X

Thymocyte development is normal in CTLA-4-deficient mice

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1600-065X.1998.TB01241.X

Defective development of thymocytes overexpressing the costimulatory molecule, heat-stable antigen

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.1998.TB01241.X

An essential role for gp39, the ligand for CD40, in thymic selection.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.1998.TB01241.X

CD28/B7 system of T cell costimulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.1998.TB01241.X

T cell receptor-dependent cell death of T cell hybridomas mediated by the CD30 cytoplasmic domain in association with tumor necrosis factor receptor-associated factors

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.1998.TB01241.X

MHC class II-positive epithelium and mesenchyme cells are both required for T-cell development in the thymus

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.1998.TB01241.X

An activated form of Notch influences the choice between CD4 and CD8 T cell lineages

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.1998.TB01241.X

Steroid production in the thymus: implications for thymocyte selection.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.1998.TB01241.X

Thymus-derived glucocorticoids regulate antigen-specific positive selection

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.1998.TB01241.X

Antagonism between Nur77 and glucocorticoid receptor for control of transcription.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.1998.TB01241.X

A new dexamethasone-induced gene of the leucine zipper family protects T lymphocytes from TCR/CD3-activated cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.1998.TB01241.X

A new member of the tumor necrosis factor/nerve growth factor receptor family inhibits T cell receptor-induced apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.1998.TB01241.X

CD8 lineage commitment in the absence of CD8.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.1998.TB01241.X

Evidence for a differential avidity model of T cell selection in the thymus

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.1998.TB01241.X

Signaling pathways that establish the dorsal-ventral pattern of the Drosophila embryo

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.1998.TB01241.X

Early molecular events induced by T cell receptor (TCR) signaling in immature CD4+ CD8+ thymocytes: increased synthesis of TCR-alpha protein is an early response to TCR signaling that compensates for TCR-alpha instability, improves TCR assembly, and

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.1998.TB01241.X

T Cells Can Be Activated by Peptides That Are Unrelated in Sequence to Their Selecting Peptide

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.1998.TB01241.X

Impaired Negative Selection of T Cells in Hodgkin's Disease Antigen CD30–Deficient Mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.1998.TB01241.X

T-cell apoptosis detected in situ during positive and negative selection in the thymus

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.1998.TB01241.X

Intrathymic signalling in immature CD4+ CD8+ thymocytes results in tyrosine phosphorylation of the T-cell receptor zeta chain

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1600-065X.1998.TB01241.X

Unopposed positive selection and autoreactivity in mice expressing class II MHC only on thymic cortex

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.1998.TB01241.X

10.1111/J.1600-065X.1998.TB01241.X

21 January 2018

Identifiers

DOI

1 reference

26 April 2018

1 reference

26 April 2018