(Q43809060)

27 November 2017

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title

Signaling checkpoints during the development of T lymphocytes (English)

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27 November 2017

Killeen N

1

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27 November 2017

Irving BA

series ordinal

2

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27 November 2017

Pippig S

series ordinal

3

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27 November 2017

Zingler K

series ordinal

4

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27 November 2017

publication date

1 June 1998

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Current Opinion in Immunology

27 November 2017

published in

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27 November 2017

volume

10

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27 November 2017

issue

3

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27 November 2017

page(s)

360-367

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Cellular interactions in thymocyte development.

27 November 2017

cites work

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2898%2980176-3

7 January 2021

Positive selection of thymocytes

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2898%2980176-3

7 January 2021

Thymic dendritic cells and T cells develop simultaneously in the thymus from a common precursor population

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2898%2980176-3

7 January 2021

A population of early fetal thymocytes expressing Fc gamma RII/III contains precursors of T lymphocytes and natural killer cells

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2898%2980176-3

7 January 2021

Developmental potential of the earliest precursor cells from the adult mouse thymus

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2898%2980176-3

7 January 2021

Early T lymphocyte progenitors

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2898%2980176-3

7 January 2021

Defective lymphoid development in mice lacking expression of the common cytokine receptor gamma chain.

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2898%2980176-3

7 January 2021

Lymphoid development in mice with a targeted deletion of the interleukin 2 receptor gamma chain.

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2898%2980176-3

7 January 2021

Early lymphocyte expansion is severely impaired in interleukin 7 receptor-deficient mice

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2898%2980176-3

7 January 2021

Intrathymically expressed c-kit ligand (stem cell factor) is a major factor driving expansion of very immature thymocytes in vivo

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2898%2980176-3

7 January 2021

Lymphopenia in interleukin (IL)-7 gene-deleted mice identifies IL-7 as a nonredundant cytokine.

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2898%2980176-3

7 January 2021

Pro-Thymocyte Expansion by c-kit and the Common Cytokine Receptor γ Chain Is Essential for Repertoire Formation

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2898%2980176-3

7 January 2021

The earliest T lineage-committed cells depend on IL-7 for Bcl-2 expression and normal cell cycle progression

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2898%2980176-3

7 January 2021

Bcl-2 rescues T lymphopoiesis in interleukin-7 receptor-deficient mice

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2898%2980176-3

7 January 2021

Bcl-2 rescues T lymphopoiesis, but not B or NK cell development, in common gamma chain-deficient mice

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2898%2980176-3

7 January 2021

Bcl-2 can rescue T lymphocyte development in interleukin-7 receptor-deficient mice but not in mutant rag-1-/- mice

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2898%2980176-3

7 January 2021

Different functions of the GTPase Rho in prothymocytes and late pre-T cells

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2898%2980176-3

7 January 2021

The GTPase Rho has a critical regulatory role in thymus development

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2898%2980176-3

7 January 2021

Induction of TCR gene rearrangements in uncommitted stem cells by a subset of IL-7 producing, MHC class-II-expressing thymic stromal cells.

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2898%2980176-3

7 January 2021

Notch activity influences the alphabeta versus gammadelta T cell lineage decision

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2898%2980176-3

7 January 2021

An activated form of Notch influences the choice between CD4 and CD8 T cell lineages

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2898%2980176-3

7 January 2021

Structure and function of the pre-T cell receptor

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2898%2980176-3

7 January 2021

Crucial role of the pre-T-cell receptor α gene in development of ap but not γδ T cells

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2898%2980176-3

7 January 2021

Mutations in T-cell antigen receptor genes alpha and beta block thymocyte development at different stages

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2898%2980176-3

7 January 2021

RAG-1-deficient mice have no mature B and T lymphocytes

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2898%2980176-3

7 January 2021

Restoration of T cell development in RAG-2-deficient mice by functional TCR transgenes.

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2898%2980176-3

7 January 2021

Function of the pre-T-cell receptor alpha chain in T-cell development and allelic exclusion at the T-cell receptor beta locus

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2898%2980176-3

7 January 2021

Essential role of the pre-T cell receptor in allelic exclusion of the T cell receptor beta locus.

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2898%2980176-3

7 January 2021

Allelic exclusion in pTalpha-deficient mice: no evidence for cell surface expression of two T cell receptor (TCR)-beta chains, but less efficient inhibition of endogeneous Vbeta--> (D)Jbeta rearrangements in the presence of a functional TCR-beta tra

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2898%2980176-3

7 January 2021

The CD3-gammadeltaepsilon and CD3-zeta/eta modules are each essential for allelic exclusion at the T cell receptor beta locus but are both dispensable for the initiation of V to (D)J recombination at the T cell receptor-beta, -gamma, and -delta loci

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2898%2980176-3

7 January 2021

Fyn can partially substitute for Lck in T lymphocyte development

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2898%2980176-3

7 January 2021

Profound block in thymocyte development in mice lacking p56lck

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2898%2980176-3

7 January 2021

alpha beta T cell development is abolished in mice lacking both Lck and Fyn protein tyrosine kinases

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2898%2980176-3

7 January 2021

An activated lck transgene promotes thymocyte development in RAG-1 mutant mice.

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2898%2980176-3

7 January 2021

Restoration of thymopoiesis in pT alpha-/- mice by anti-CD3epsilon antibody treatment or with transgenes encoding activated Lck or tailless pT alpha.

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2898%2980176-3

7 January 2021

The Syk and ZAP-70 SH2-containing tyrosine kinases are implicated in pre-T cell receptor signaling

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2898%2980176-3

7 January 2021

CD45-null transgenic mice reveal a positive regulatory role for CD45 in early thymocyte development, in the selection of CD4+CD8+ thymocytes, and B cell maturation

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2898%2980176-3

7 January 2021

A Requirement for the Rho-Family GTP Exchange Factor Vav in Positive and Negative Selection of Thymocytes

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2898%2980176-3

7 January 2021

Exit of the pre-TCR from the ER/cis-Golgi is necessary for signaling differentiation, proliferation, and allelic exclusion in immature thymocytes.

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2898%2980176-3

7 January 2021

Thymocyte development in the absence of pre-T cell receptor extracellular immunoglobulin domains

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2898%2980176-3

7 January 2021

Redundant regulation of T cell differentiation and TCRalpha gene expression by the transcription factors LEF-1 and TCF-1

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2898%2980176-3

7 January 2021

Two distinct steps during thymocyte maturation from CD4-CD8- to CD4+CD8+ distinguished in the early growth response (Egr)-1 transgenic mice with a recombinase-activating gene-deficient background

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2898%2980176-3

7 January 2021

In thymic selection, peptide diversity gives and takes away

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2898%2980176-3

7 January 2021

T-cell-receptor affinity and thymocyte positive selection

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2898%2980176-3

7 January 2021

Interactions of TCRs with MHC-peptide complexes: a quantitative basis for mechanistic models

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2898%2980176-3

7 January 2021

TCR zeta chain in T cell development and selection

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2898%2980176-3

7 January 2021

Helper T-cell development in the absence of CD4-p56 Ick association

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2898%2980176-3

7 January 2021

Participation of CD4 coreceptor molecules in T-cell repertoire selection

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2898%2980176-3

7 January 2021

Essential role for ZAP-70 in both positive and negative selection of thymocytes

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2898%2980176-3

7 January 2021

Phosphotyrosine-dependent activation of Rac-1 GDP/GTP exchange by the vav proto-oncogene product

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2898%2980176-3

7 January 2021

Tyrosine phosphorylation of the vav proto-oncogene product links FcepsilonRI to the Rac1-JNK pathway

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2898%2980176-3

7 January 2021

Defective T-cell receptor signalling and positive selection of Vav-deficient CD4+ CD8+ thymocytes

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2898%2980176-3

7 January 2021

Defective antigen receptor-mediated proliferation of B and T cells in the absence of Vav.

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2898%2980176-3

7 January 2021

Defective signalling through the T- and B-cell antigen receptors in lymphoid cells lacking the vav proto-oncogene

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2898%2980176-3

7 January 2021

Thymocyte lineage commitment: is it instructed or stochastic?

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2898%2980176-3

7 January 2021

Selective events in T cell development

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2898%2980176-3

7 January 2021

MHC class II interaction with CD4 mediated by a region analogous to the MHC class I binding site for CD8

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2898%2980176-3

7 January 2021

Polymorphism in the alpha 3 domain of HLA-A molecules affects binding to CD8.

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2898%2980176-3

7 January 2021

The CD4 receptor is complexed in detergent lysates to a protein-tyrosine kinase (pp58) from human T lymphocytes

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2898%2980176-3

7 January 2021

Interaction of the unique N-terminal region of tyrosine kinase p56lck with cytoplasmic domains of CD4 and CD8 is mediated by cysteine motifs

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2898%2980176-3

7 January 2021

The CD4 and CD8 T cell surface antigens are associated with the internal membrane tyrosine-protein kinase p56lck

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2898%2980176-3

7 January 2021

CD8 is needed for development of cytotoxic T cells but not helper T cells

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2898%2980176-3

7 January 2021

Thymic selection of cytotoxic T cells independent of CD8 alpha-Lck association

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2898%2980176-3

7 January 2021

CD8 lineage commitment in the absence of CD8.

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2898%2980176-3

7 January 2021

Peptide-induced positive selection of TCR transgenic thymocytes in a coreceptor-independent manner.

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2898%2980176-3

7 January 2021

Helper T cells without CD4: control of leishmaniasis in CD4-deficient mice

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2898%2980176-3

7 January 2021

Class II major histocompatibility complex-restricted T cell function in CD4-deficient mice

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2898%2980176-3

7 January 2021

The cytoplasmic domain of CD4 promotes the development of CD4 lineage T cells

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2898%2980176-3

7 January 2021

MHC class II-specific T cells can develop in the CD8 lineage when CD4 is absent.

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2898%2980176-3

7 January 2021

Differential induction of helper and killer T cells from isolated CD4+CD8+ thymocytes in suspension culture.

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2898%2980176-3

7 January 2021

Selective requirement for MAP kinase activation in thymocyte differentiation.

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2898%2980176-3

7 January 2021

Positive and negative selection invoke distinct signaling pathways.

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2898%2980176-3

7 January 2021

The MAP kinase pathway controls differentiation from double-negative to double-positive thymocyte.

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2898%2980176-3

7 January 2021

The influence of the MAPK pathway on T cell lineage commitment

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2898%2980176-3

7 January 2021

T-cell co-receptors. The end of a frustrating search

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2898%2980176-3

7 January 2021

An enhancer that directs lineage-specific expression of CD8 in positively selected thymocytes and mature T cells.

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2898%2980176-3

7 January 2021

A region in the CD8 gene locus that directs expression to the mature CD8 T cell subset in transgenic mice

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2898%2980176-3

7 January 2021

Surface molecules that drive T cell development in vitro in the absence of thymic epithelium and in the absence of lineage-specific signals

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2898%2980176-3

7 January 2021

Intrathymic T cell receptor (TcR) targeting in mice lacking CD4 or major histocompatibility complex (MHC) class II: rescue of CD4 T cell lineage without co-engagement of TcR/CD4 by MHC class II.

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2898%2980176-3

7 January 2021

T cell receptor targeting to thymic cortical epithelial cells in vivo induces survival, activation and differentiation of immature thymocytes

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2898%2980176-3

7 January 2021

Two separable T cell receptor signals reconstitute positive selection of CD4 lineage T cells in vivo.

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2898%2980176-3

7 January 2021

Positive selection of T cells induced by viral delivery of neopeptides to the thymus

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2898%2980176-3

7 January 2021

Thymic emigration: conveyor belts or lucky dips?

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2898%2980176-3

7 January 2021

Impaired immunoglobulin gene rearrangement in mice lacking the IL-7 receptor

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2898%2980176-3

7 January 2021

10.1016/S0952-7915(98)80176-3

Identifiers

DOI

1 reference

27 November 2017

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