(Q52431252)

1 May 2018

title

Natural regulatory mutations elevate the fetal globin gene via disruption of BCL11A or ZBTB7A binding. (English)

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1 May 2018

Merlin Crossley

12

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Ryo Kurita

7

object named as

Ryo Kurita

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1 May 2018

author name string

Gabriella E Martyn

1

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1 May 2018

Beeke Wienert

2

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1 May 2018

Lu Yang

3

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1 May 2018

Manan Shah

4

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1 May 2018

Laura J Norton

5

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1 May 2018

Jon Burdach

6

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1 May 2018

Yukio Nakamura

8

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1 May 2018

Richard C M Pearson

9

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1 May 2018

Alister P W Funnell

10

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1 May 2018

Kate G R Quinlan

11

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1 May 2018

language of work or name

English

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publication date

2 April 2018

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1 May 2018

number of pages

6

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inferred from page(s)

published in

Nature Genetics

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1 May 2018

volume

50

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1 May 2018

issue

4

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1 May 2018

page(s)

498-503

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1 May 2018

https://scigraph.springernature.com/pub.10.1038/s41588-018-0085-0

exact match

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cites work

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Transcriptional regulation of fetal to adult hemoglobin switching: new therapeutic opportunities

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A point mutation in the A gamma-globin gene promoter in Greek hereditary persistence of fetal haemoglobin

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A novel C-T transition within the distal CCAAT motif of the Gγ-globin gene in the Japanese HPFH: implication of factor binding in elevated fetal globin expression

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Distal CCAAT box deletion in the A gamma globin gene of two black adolescents with elevated fetal A gamma globin

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7 January 2021

A novel C-->A transversion within the distal CCAAT motif of the Ggamma-globin gene in the Algerian Ggammabeta+-hereditary persistence of fetal hemoglobin

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A molecular study of a family with Greek hereditary persistence of fetal hemoglobin and beta-thalassemia

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7 January 2021

G gamma-196 C-->T, A gamma-201 C-->T: two novel mutations in the promoter region of the gamma-globin genes associated with nondeletional hereditary persistence of fetal hemoglobin in Greece

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7 January 2021

Interpreting elevated fetal hemoglobin in pathology and health at the basic laboratory level: new and known γ- gene mutations associated with hereditary persistence of fetal hemoglobin

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7 January 2021

G gamma beta+ hereditary persistence of fetal hemoglobin: cosmid cloning and identification of a specific mutation 5' to the G gamma gene

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Haplotypes of beta S chromosomes among patients with sickle cell anemia from Georgia

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The Australian type of nondeletional G gamma-HPFH has a C-->G substitution at nucleotide -114 of the G gamma gene

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7 January 2021

Genome-wide association study shows BCL11A associated with persistent fetal hemoglobin and amelioration of the phenotype of beta-thalassemia

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A QTL influencing F cell production maps to a gene encoding a zinc-finger protein on chromosome 2p15.

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7 January 2021

An erythroid enhancer of BCL11A subject to genetic variation determines fetal hemoglobin level.

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7 January 2021

Developmental and species-divergent globin switching are driven by BCL11A

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7 January 2021

Correction of sickle cell disease in adult mice by interference with fetal hemoglobin silencing

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LRF-mediated Dll4 repression in erythroblasts is necessary for hematopoietic stem cell maintenance.

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7 January 2021

Transcription factors LRF and BCL11A independently repress expression of fetal hemoglobin

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Establishment of immortalized human erythroid progenitor cell lines able to produce enucleated red blood cells

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7 January 2021

Transcriptional silencing of {gamma}-globin by BCL11A involves long-range interactions and cooperation with SOX6.

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7 January 2021

Comparative analysis of three-dimensional chromosomal architecture identifies a novel fetal hemoglobin regulatory element.

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7 January 2021

Editing the genome to introduce a beneficial naturally occurring mutation associated with increased fetal globin.

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7 January 2021

Human fetal hemoglobin expression is regulated by the developmental stage-specific repressor BCL11A.

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7 January 2021

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7 January 2021

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Identifiers

DOI

1 reference

1 May 2018

Dimensions Publication ID

0 references

1 reference

1 May 2018