(Q52612153)

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Comparison of protein expression between human livers and the hepatic cell lines HepG2, Hep3B, and Huh7 using SWATH and MRM-HR proteomics: Focusing on drug-metabolizing enzymes.

scientific article published on 10 March 2018

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scholarly article

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22 March 2020

Comparison of protein expression between human livers and the hepatic cell lines HepG2, Hep3B, and Huh7 using SWATH and MRM-HR proteomics: Focusing on drug-metabolizing enzymes (English)

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22 March 2020

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22 March 2020

4

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22 March 2020

author name string

Xinwen Wang

2

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22 March 2020

Lingyun Lyu

3

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22 March 2020

Hao-Jie Zhu

5

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22 March 2020

publication date

10 March 2018

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22 March 2020

Drug Metabolism and Pharmacokinetics

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22 March 2020

33

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22 March 2020

2

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22 March 2020

133-140

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22 March 2020

describes a project that uses

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Controlled synthesis of HBsAg in a differentiated human liver carcinoma-derived cell line

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https://pubmed.ncbi.nlm.nih.gov/29610054

12 December 2020

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Human hepatocellular carcinoma cell lines secrete the major plasma proteins and hepatitis B surface antigen

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12 December 2020

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Growth of human hepatoma cells lines with differentiated functions in chemically defined medium

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https://pubmed.ncbi.nlm.nih.gov/29610054

12 December 2020

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12 December 2020

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Acetaminophen hepatotoxicity and mechanisms of its protection by N-acetylcysteine: a study of Hep3B cells

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12 December 2020

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Gene expression profiling and differentiation assessment in primary human hepatocyte cultures, established hepatoma cell lines, and human liver tissues

1 reference

https://pubmed.ncbi.nlm.nih.gov/29610054

12 December 2020

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Cytochrome P450 enzyme levels in HepG2 cells and cryopreserved primary human hepatocytes and their induction in HepG2 cells

1 reference

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12 December 2020

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Andrographolide inhibits human hepatoma-derived Hep3B cell growth through the activation of c-Jun N-terminal kinase

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12 December 2020

based on heuristic

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Genetic basis of proteome variation in yeast

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12 December 2020

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Long chain acyl-CoA synthetase 3-mediated phosphatidylcholine synthesis is required for assembly of very low density lipoproteins in human hepatoma Huh7 cells

1 reference

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12 December 2020

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New era in drug interaction evaluation: US Food and Drug Administration update on CYP enzymes, transporters, and the guidance process

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Liver cancer stem cells

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12 December 2020

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Aldehyde dehydrogenase discriminates the CD133 liver cancer stem cell populations.

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12 December 2020

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Selected reaction monitoring for quantitative proteomics: a tutorial

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12 December 2020

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Genistein enhances TRAIL-induced apoptosis through inhibition of p38 MAPK signaling in human hepatocellular carcinoma Hep3B cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/29610054

12 December 2020

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Cell characterization by proteome profiling applied to primary hepatocytes and hepatocyte cell lines Hep-G2 and Hep-3B.

1 reference

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12 December 2020

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Emodin inhibits the growth of hepatoma cells: finding the common anti-cancer pathway using Huh7, Hep3B, and HepG2 cells

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https://pubmed.ncbi.nlm.nih.gov/29610054

12 December 2020

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Comparison of HepG2 and HepaRG by whole-genome gene expression analysis for the purpose of chemical hazard identification

1 reference

https://pubmed.ncbi.nlm.nih.gov/29610054

12 December 2020

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Skyline: an open source document editor for creating and analyzing targeted proteomics experiments

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https://pubmed.ncbi.nlm.nih.gov/29610054

12 December 2020

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A comparison of whole genome gene expression profiles of HepaRG cells and HepG2 cells to primary human hepatocytes and human liver tissues.

1 reference

https://pubmed.ncbi.nlm.nih.gov/29610054

12 December 2020

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Isolation and culture of primary hepatocytes from resected human liver tissue

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https://pubmed.ncbi.nlm.nih.gov/29610054

12 December 2020

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HNF4α--role in drug metabolism and potential drug target?

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https://pubmed.ncbi.nlm.nih.gov/29610054

12 December 2020

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Huh-7 or HepG2 cells: which is the better model for studying human apolipoprotein-B100 assembly and secretion?

1 reference

https://pubmed.ncbi.nlm.nih.gov/29610054

12 December 2020

based on heuristic

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Similarities and differences in the expression of drug-metabolizing enzymes between human hepatic cell lines and primary human hepatocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/29610054

12 December 2020

based on heuristic

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Reliability and robustness of simultaneous absolute quantification of drug transporters, cytochrome P450 enzymes, and Udp-glucuronosyltransferases in human liver tissue by multiplexed MRM/selected reaction monitoring mode tandem mass spectrometry wi

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https://pubmed.ncbi.nlm.nih.gov/29610054

12 December 2020

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12 December 2020

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12 December 2020

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Transcriptomic and quantitative proteomic analysis of transporters and drug metabolizing enzymes in freshly isolated human brain microvessels.

1 reference

https://pubmed.ncbi.nlm.nih.gov/29610054

12 December 2020

based on heuristic

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https://pubmed.ncbi.nlm.nih.gov/29610054

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Parallel reaction monitoring for high resolution and high mass accuracy quantitative, targeted proteomics

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Large-Scale Quantitative Assessment of Different In-Solution Protein Digestion Protocols Reveals Superior Cleavage Efficiency of Tandem Lys-C/Trypsin Proteolysis over Trypsin Digestion

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Quantifying protein interaction dynamics by SWATH mass spectrometry: application to the 14-3-3 system

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1 reference

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Extending the limits of quantitative proteome profiling with data-independent acquisition and application to acetaminophen-treated three-dimensional liver microtissues.

1 reference

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Comparative Proteomic Characterization of 4 Human Liver-Derived Single Cell Culture Models Reveals Significant Variation in the Capacity for Drug Disposition, Bioactivation, and Detoxication

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Multiplexed, Scheduled, High-Resolution Parallel Reaction Monitoring on a Full Scan QqTOF Instrument with Integrated Data-Dependent and Targeted Mass Spectrometric Workflows

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Large-scale multiplex absolute protein quantification of drug-metabolizing enzymes and transporters in human intestine, liver, and kidney microsomes by SWATH-MS: Comparison with MRM/SRM and HR-MRM/PRM.

1 reference

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Identifiers

10.1016/J.DMPK.2018.03.003

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29610054%20AND%20SRC:MED&resulttype=core&format=json

22 March 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29610054%20AND%20SRC:MED&resulttype=core&format=json

22 March 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29610054%20AND%20SRC:MED&resulttype=core&format=json

22 March 2020

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