(Q52654990)

English

Atlas stumbled: kinesin light chain-1 variant E triggers a vicious cycle of axonal transport disruption and amyloid-β generation in Alzheimer's disease.

scientific article published on 13 November 2014

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scholarly article

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Europe PubMed Central

5 May 2018

http://europepmc.org/abstract/MED/25394182

Atlas stumbled: kinesin light chain-1 variant E triggers a vicious cycle of axonal transport disruption and amyloid-β generation in Alzheimer's disease. (English)

1 reference

Europe PubMed Central

5 May 2018

http://europepmc.org/abstract/MED/25394182

Michael A. Silverman

3

1 reference

Europe PubMed Central

5 May 2018

http://europepmc.org/abstract/MED/25394182

author name string

Kathlyn J Gan

1

1 reference

Europe PubMed Central

5 May 2018

http://europepmc.org/abstract/MED/25394182

Takashi Morihara

2

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Europe PubMed Central

5 May 2018

http://europepmc.org/abstract/MED/25394182

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publication date

13 November 2014

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Europe PubMed Central

5 May 2018

http://europepmc.org/abstract/MED/25394182

1 reference

Europe PubMed Central

5 May 2018

http://europepmc.org/abstract/MED/25394182

37

1 reference

Europe PubMed Central

5 May 2018

http://europepmc.org/abstract/MED/25394182

131-141

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Europe PubMed Central

5 May 2018

http://europepmc.org/abstract/MED/25394182

2

1 reference

Europe PubMed Central

5 May 2018

http://europepmc.org/abstract/MED/25394182

Neuronal polarity: from extracellular signals to intracellular mechanisms

1 reference

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Releasing the brake: restoring fast axonal transport in neurodegenerative disorders.

1 reference

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21 January 2018

Axonal transport deficits and neurodegenerative diseases

1 reference

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21 January 2018

Integrated regulation of motor-driven organelle transport by scaffolding proteins

1 reference

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21 January 2018

Axonal transport plays a crucial role in mediating the axon-protective effects of NmNAT

1 reference

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21 January 2018

Axonal transport and neurodegenerative disease: can we see the elephant?

1 reference

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21 January 2018

Impairments in fast axonal transport and motor neuron deficits in transgenic mice expressing familial Alzheimer's disease-linked mutant presenilin 1

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201400131

21 January 2018

Delivery of GABAARs to synapses is mediated by HAP1-KIF5 and disrupted by mutant huntingtin.

1 reference

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21 January 2018

DCTN1 mutations in Perry syndrome

1 reference

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21 January 2018

Segregation of a missense mutation in the microtubule-associated protein tau gene with familial frontotemporal dementia and parkinsonism.

1 reference

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21 January 2018

Trafficking regulation of proteins in Alzheimer's disease

1 reference

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21 January 2018

Biological function of Presenilin and its role in AD pathogenesis

1 reference

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21 January 2018

Mutant presenilins of Alzheimer's disease increase production of 42-residue amyloid beta-protein in both transfected cells and transgenic mice

1 reference

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21 January 2018

Alzheimer's disease-type neuronal tau hyperphosphorylation induced by A beta oligomers

1 reference

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21 January 2018

The many faces of tau

1 reference

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21 January 2018

Amyloid beta-mediated cell death of cultured hippocampal neurons reveals extensive Tau fragmentation without increased full-length tau phosphorylation

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201400131

21 January 2018

Axonal transport and Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201400131

21 January 2018

Axonal transport defects in neurodegenerative diseases

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201400131

21 January 2018

Clogging of axons by tau, inhibition of axonal traffic and starvation of synapses.

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201400131

21 January 2018

The amino terminus of tau inhibits kinesin-dependent axonal transport: implications for filament toxicity.

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201400131

21 January 2018

Pathogenic forms of tau inhibit kinesin-dependent axonal transport through a mechanism involving activation of axonal phosphotransferases

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201400131

21 January 2018

Amyloid-β oligomers induce tau-independent disruption of BDNF axonal transport via calcineurin activation in cultured hippocampal neurons

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201400131

21 January 2018

Amyloid precursor protein-induced axonopathies are independent of amyloid-beta peptides

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201400131

21 January 2018

Enhanced β-secretase processing alters APP axonal transport and leads to axonal defects

1 reference

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21 January 2018

In vivo imaging of axonal transport using MRI: aging and Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201400131

21 January 2018

Deficits in axonal transport in hippocampal-based circuitry and the visual pathway in APP knock-out animals witnessed by manganese enhanced MRI.

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201400131

21 January 2018

Axonopathy and transport deficits early in the pathogenesis of Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201400131

21 January 2018

Transcriptome analysis of distinct mouse strains reveals kinesin light chain-1 splicing as an amyloid-β accumulation modifier.

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201400131

21 January 2018

A standardized kinesin nomenclature

1 reference

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21 January 2018

Molecular motors in neurons: transport mechanisms and roles in brain function, development, and disease.

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201400131

21 January 2018

All kinesin superfamily protein, KIF, genes in mouse and human

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201400131

21 January 2018

Axon and dendritic trafficking

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201400131

21 January 2018

Microtubule-based transport - basic mechanisms, traffic rules and role in neurological pathogenesis

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201400131

21 January 2018

Native structure and physical properties of bovine brain kinesin and identification of the ATP-binding subunit polypeptide

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201400131

21 January 2018

Cloning and localization of a conventional kinesin motor expressed exclusively in neurons

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201400131

21 January 2018

Kinesin's light chains inhibit the head- and microtubule-binding activity of its tail

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201400131

21 January 2018

The kinesin-1 motor protein is regulated by a direct interaction of its head and tail

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201400131

21 January 2018

The Structure of the Kinesin-1 Motor-Tail Complex Reveals the Mechanism of Autoinhibition

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201400131

21 January 2018

The tetrameric molecule of conventional kinesin contains identical light chains

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201400131

21 January 2018

The C-terminal region of the stalk domain of ubiquitous human kinesin heavy chain contains the binding site for kinesin light chain.

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201400131

21 January 2018

Immunochemical analysis of kinesin light chain function

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201400131

21 January 2018

Kinesin light chains are essential for axonal transport in Drosophila

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201400131

21 January 2018

Cargo of kinesin identified as JIP scaffolding proteins and associated signaling molecules

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201400131

21 January 2018

Structural Basis for Kinesin-1:Cargo Recognition

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201400131

21 January 2018

Alternatively spliced products of the human kinesin light chain 1 (KNS2) gene

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201400131

21 January 2018

A specific light chain of kinesin associates with mitochondria in cultured cells

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201400131

21 January 2018

Cargo selection by specific kinesin light chain 1 isoforms.

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201400131

21 January 2018

Functional and structural characterization of a dense core secretory granule sorting domain from the PC1/3 protease

1 reference

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21 January 2018

Differential dynamics of Rab3A and Rab27A on secretory granules.

1 reference

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21 January 2018

Distinct molecular mechanisms for protein sorting within immature secretory granules of pancreatic beta-cells

1 reference

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21 January 2018

Kinesin-mediated axonal transport of a membrane compartment containing beta-secretase and presenilin-1 requires APP

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201400131

21 January 2018

Axonal transport of amyloid precursor protein is mediated by direct binding to the kinesin light chain subunit of kinesin-I

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201400131

21 January 2018

Two binding partners cooperate to activate the molecular motor Kinesin-1.

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201400131

21 January 2018

Axonal transport, amyloid precursor protein, kinesin-1, and the processing apparatus: revisited

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201400131

21 January 2018

Activity-induced convergence of APP and BACE-1 in acidic microdomains via an endocytosis-dependent pathway.

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201400131

21 January 2018

JIP1 regulates the directionality of APP axonal transport by coordinating kinesin and dynein motors

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201400131

21 January 2018

Kinesin light chain 1 suppression impairs human embryonic stem cell neural differentiation and amyloid precursor protein metabolism

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201400131

21 January 2018

Novel beta-secretase cleavage of beta-amyloid precursor protein in the endoplasmic reticulum/intermediate compartment of NT2N cells

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201400131

21 January 2018

A persistent stress response to impeded axonal transport leads to accumulation of amyloid-β in the endoplasmic reticulum, and is a probable cause of sporadic Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201400131

21 January 2018

Coordinated transport of phosphorylated amyloid-beta precursor protein and c-Jun NH2-terminal kinase-interacting protein-1

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201400131

21 January 2018

The cleavage products of amyloid-beta precursor protein are sorted to distinct carrier vesicles that are independently transported within neurites.

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201400131

21 January 2018

The role of endoplasmic reticulum in amyloid precursor protein processing and trafficking: implications for Alzheimer's disease.

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201400131

21 January 2018

Endoplasmic reticulum dysfunction in Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201400131

21 January 2018

Lipoprotein receptors and cholesterol in APP trafficking and proteolytic processing, implications for Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201400131

21 January 2018

Apolipoprotein E and apolipoprotein E receptors: normal biology and roles in Alzheimer disease

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201400131

21 January 2018

ApoER2 expression increases Abeta production while decreasing Amyloid Precursor Protein (APP) endocytosis: Possible role in the partitioning of APP into lipid rafts and in the regulation of gamma-secretase activity.

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201400131

21 January 2018

Calsyntenin-1 mediates axonal transport of the amyloid precursor protein and regulates Aβ production

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201400131

21 January 2018

Calsyntenins mediate TGN exit of APP in a kinesin-1-dependent manner.

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201400131

21 January 2018

Calsyntenin-1 shelters APP from proteolytic processing during anterograde axonal transport

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201400131

21 January 2018

Kinesin adapter JLP links PIKfyve to microtubule-based endosome-to-trans-Golgi network traffic of furin

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201400131

21 January 2018

Furin is an endogenous regulator of alpha-secretase associated APP processing.

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201400131

21 January 2018

Intracellular amyloid-beta in Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201400131

21 January 2018

Altered localization of amyloid precursor protein under endoplasmic reticulum stress

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201400131

21 January 2018

Alzheimer's Disease

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201400131

21 January 2018

The ratio of monomeric to aggregated forms of Abeta40 and Abeta42 is an important determinant of amyloid-beta aggregation, fibrillogenesis, and toxicity

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201400131

21 January 2018

Amyloid beta-protein (Abeta)1-40 protects neurons from damage induced by Abeta1-42 in culture and in rat brain.

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201400131

21 January 2018

Picomolar amyloid-beta positively modulates synaptic plasticity and memory in hippocampus

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201400131

21 January 2018

Endogenous amyloid-β is necessary for hippocampal synaptic plasticity and memory

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201400131

21 January 2018

Reimagining Alzheimer's disease--an age-based hypothesis

1 reference

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21 January 2018

The toxic Aβ oligomer and Alzheimer's disease: an emperor in need of clothes

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201400131

21 January 2018

The Aβ oligomer hypothesis for synapse failure and memory loss in Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201400131

21 January 2018

Alzheimer Aβ disrupts the mitotic spindle and directly inhibits mitotic microtubule motors

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201400131

21 January 2018

Alzheimer amyloid beta inhibition of Eg5/kinesin 5 reduces neurotrophin and/or transmitter receptor function

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201400131

21 January 2018

New insights into the role of glycogen synthase kinase-3 in Alzheimer's disease.

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201400131

21 January 2018

Inhibition of GSK3β-mediated BACE1 expression reduces Alzheimer-associated phenotypes

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201400131

21 January 2018

Presenilin-1 is an unprimed glycogen synthase kinase-3beta substrate

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201400131

21 January 2018

In Vitro Phosphorylation of the Cytoplasmic Domain of the Amyloid Precursor Protein by Glycogen Synthase Kinase-3β

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201400131

21 January 2018

Endogenous GSK-3/shaggy regulates bidirectional axonal transport of the amyloid precursor protein

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201400131

21 January 2018

Glycogen synthase kinase 3 phosphorylates kinesin light chains and negatively regulates kinesin-based motility

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201400131

21 January 2018

Nebula/DSCR1 upregulation delays neurodegeneration and protects against APP-induced axonal transport defects by restoring calcineurin and GSK-3β signaling

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201400131

21 January 2018

Physiological regulation of the beta-amyloid precursor protein signaling domain by c-Jun N-terminal kinase JNK3 during neuronal differentiation.

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201400131

21 January 2018

JNK regulates APP cleavage and degradation in a model of Alzheimer's disease.

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201400131

21 January 2018

An anti-diabetes agent protects the mouse brain from defective insulin signaling caused by Alzheimer's disease- associated Aβ oligomers

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201400131

21 January 2018

Control of a kinesin-cargo linkage mechanism by JNK pathway kinases

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201400131

21 January 2018

Regulation of amyloid precursor protein processing by serotonin signaling

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201400131

21 January 2018

Disruption of fast axonal transport is a pathogenic mechanism for intraneuronal amyloid beta

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201400131

21 January 2018

Protein kinases CK1 and CK2 as new targets for neurodegenerative diseases

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201400131

21 January 2018

Neuron-specific phosphorylation of Alzheimer's beta-amyloid precursor protein by cyclin-dependent kinase 5.

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201400131

21 January 2018

APP processing is regulated by cytoplasmic phosphorylation

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201400131

21 January 2018

C-terminal neurofilament phosphorylation fosters neurofilament-neurofilament associations that compete with axonal transport.

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201400131

21 January 2018

A novel CDK5-dependent pathway for regulating GSK3 activity and kinesin-driven motility in neurons

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201400131

21 January 2018

Kidins220/ARMS is transported by a kinesin-1-based mechanism likely to be involved in neuronal differentiation

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201400131

21 January 2018

Crystal structures of the tetratricopeptide repeat domains of kinesin light chains: insight into cargo recognition mechanisms

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201400131

21 January 2018

Phosphorylation of kinesin light chain 1 at serine 460 modulates binding and trafficking of calsyntenin-1.

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201400131

21 January 2018

Autoinhibition of the kinesin-2 motor KIF17 via dual intramolecular mechanisms

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201400131

21 January 2018

Kinesin-1 structural organization and conformational changes revealed by FRET stoichiometry in live cells

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201400131

21 January 2018

Manganese enhanced MRI (MEMRI): neurophysiological applications

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201400131

21 January 2018

Pathway analysis of the human brain transcriptome in disease

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201400131

21 January 2018

Three novel alternatively spliced isoforms of the human beta-site amyloid precursor protein cleaving enzyme (BACE) and their effect on amyloid beta-peptide production

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201400131

21 January 2018

Identifiers

10.1002/BIES.201400131

1 reference

Europe PubMed Central

5 May 2018

http://europepmc.org/abstract/MED/25394182

1 reference

Europe PubMed Central

5 May 2018

http://europepmc.org/abstract/MED/25394182

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