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Mechanisms of ketamine action as an antidepressant.
scientific article published on 13 March 2018
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Europe PubMed Central
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5999402
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29532791%20AND%20SRC:MED&resulttype=core&format=json
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20 March 2020
title
Mechanisms of ketamine action as an antidepressant
(English)
1 reference
stated in
Europe PubMed Central
PMC publication ID
5999402
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29532791%20AND%20SRC:MED&resulttype=core&format=json
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20 March 2020
author
Panos Zanos
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1
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Europe PubMed Central
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5999402
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29532791%20AND%20SRC:MED&resulttype=core&format=json
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20 March 2020
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T D Gould
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2
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Europe PubMed Central
PMC publication ID
5999402
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29532791%20AND%20SRC:MED&resulttype=core&format=json
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20 March 2020
language of work or name
English
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publication date
13 March 2018
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5999402
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retrieved
20 March 2020
published in
Molecular Psychiatry
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5999402
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20 March 2020
volume
23
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Europe PubMed Central
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5999402
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20 March 2020
issue
4
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Europe PubMed Central
PMC publication ID
5999402
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29532791%20AND%20SRC:MED&resulttype=core&format=json
retrieved
20 March 2020
page(s)
801-811
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Europe PubMed Central
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5999402
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20 March 2020
exact match
https://scigraph.springernature.com/pub.10.1038/mp.2017.255
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Selective Pharmacological Augmentation of Hippocampal Activity Produces a Sustained Antidepressant-Like Response without Abuse-Related or Psychotomimetic Effects
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Habenula-Induced Inhibition of Midbrain Dopamine Neurons Is Diminished by Lesions of the Rostromedial Tegmental Nucleus
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Essential roles of AMPA receptor GluA1 phosphorylation and presynaptic HCN channels in fast-acting antidepressant responses of ketamine
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The Role of GluN2C-Containing NMDA Receptors in Ketamine's Psychotogenic Action and in Schizophrenia Models
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Adjunctive Lanicemine (AZD6765) in Patients with Major Depressive Disorder and History of Inadequate Response to Antidepressants: A Randomized, Placebo-Controlled Study
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The Rapidly Acting Antidepressant Ketamine and the mGlu2/3 Receptor Antagonist LY341495 Rapidly Engage Dopaminergic Mood Circuits
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Bidirectional Homeostatic Regulation of a Depression-Related Brain State by Gamma-Aminobutyric Acidergic Deficits and Ketamine Treatment
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Intravenous Esketamine in Adult Treatment-Resistant Depression: A Double-Blind, Double-Randomization, Placebo-Controlled Study
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GLYX-13 (rapastinel) ameliorates subchronic phencyclidine- and ketamine-induced declarative memory deficits in mice
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Ketamine and Other NMDA Antagonists: Early Clinical Trials and Possible Mechanisms in Depression.
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The long-lasting antidepressant effects of rapastinel (GLYX-13) are associated with a metaplasticity process in the medial prefrontal cortex and hippocampus
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Evidence that Subanesthetic Doses of Ketamine Cause Sustained Disruptions of NMDA and AMPA-Mediated Frontoparietal Connectivity in Humans
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The Prodrug 4-Chlorokynurenine Causes Ketamine-Like Antidepressant Effects, but Not Side Effects, by NMDA/GlycineB-Site Inhibition.
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Rapid Antidepressant Action and Restoration of Excitatory Synaptic Strength After Chronic Stress by Negative Modulators of Alpha5-Containing GABAA Receptors
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NMDA receptor subunits and associated signaling molecules mediating antidepressant-related effects of NMDA-GluN2B antagonism
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Impact of subanesthetic doses of ketamine on AMPA-mediated responses in rats: An in vivo electrophysiological study on monoaminergic and glutamatergic neurons
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Neural correlates of change in major depressive disorder anhedonia following open-label ketamine
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Contributions of diverse excitatory and inhibitory neurons to recurrent network activity in cerebral cortex
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BDNF release is required for the behavioral actions of ketamine
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GluN2B-containing NMDA receptors regulate depression-like behavior and are critical for the rapid antidepressant actions of ketamine
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Anti-anhedonic effect of ketamine and its neural correlates in treatment-resistant bipolar depression
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Improvement in suicidal ideation after ketamine infusion: relationship to reductions in depression and anxiety.
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(R,S)-Ketamine metabolites (R,S)-norketamine and (2S,6S)-hydroxynorketamine increase the mammalian target of rapamycin function.
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Mechanisms underlying differential effectiveness of memantine and ketamine in rapid antidepressant responses
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Requirement of AMPA receptor stimulation for the sustained antidepressant activity of ketamine and LY341495 during the forced swim test in rats
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The role of GluN2A and GluN2B subunits on the effects of NMDA receptor antagonists in modeling schizophrenia and treating refractory depression
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Effects of ketamine on explicit and implicit suicidal cognition: a randomized controlled trial in treatment-resistant depression
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R (-)-ketamine shows greater potency and longer lasting antidepressant effects than S (+)-ketamine
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Antidepressant efficacy of ketamine in treatment-resistant major depression: a two-site randomized controlled trial
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Ketamine alters oscillatory coupling in the hippocampus
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24 June 2018
GSK-3 inhibition potentiates the synaptogenic and antidepressant-like effects of subthreshold doses of ketamine
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Acute suppression of spontaneous neurotransmission drives synaptic potentiation
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Ketamine: use in anesthesia
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24 June 2018
NMDA receptor blockade by ketamine abrogates lipopolysaccharide-induced depressive-like behavior in C57BL/6J mice
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24 June 2018
GLYX-13, a NMDA receptor glycine-site functional partial agonist, induces antidepressant-like effects without ketamine-like side effects
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24 June 2018
A randomized trial of a low-trapping nonselective N-methyl-D-aspartate channel blocker in major depression
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13 August 2018
Intracellular Signaling Pathways Involved in (S)- and (R)-Ketamine Antidepressant Actions.
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5999402
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13 August 2018
Effects of a ketamine metabolite on synaptic NMDAR function.
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5999402
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13 August 2018
Antidepressant Potential of (R)-Ketamine in Rodent Models: Comparison with (S)-Ketamine.
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5999402
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13 August 2018
(R)-Ketamine Shows Greater Potency and Longer Lasting Antidepressant Effects Than Its Metabolite (2R,6R)-Hydroxynorketamine.
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5999402
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13 August 2018
GLYX-13 Produces Rapid Antidepressant Responses with Key Synaptic and Behavioral Effects Distinct from Ketamine.
1 reference
stated in
PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5999402
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13 August 2018
Differential regulation of GluA1 expression by ketamine and memantine.
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5999402
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13 August 2018
Ketamine for Depression: An Update
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5999402
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13 August 2018
What Are We Learning From Early-Phase Clinical Trials With Glutamate Targeting Medications for the Treatment of Major Depressive Disorder
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5999402
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13 August 2018
Rapamycin blocks the antidepressant effect of ketamine in task-dependent manner.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5999402
retrieved
13 August 2018
Ketamine-like effects of a combination of olanzapine and fluoxetine on AMPA and NMDA receptor-mediated transmission in the medial prefrontal cortex of the rat.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5999402
retrieved
13 August 2018
Dopamine D2/D3 but not dopamine D1 receptors are involved in the rapid antidepressant-like effects of ketamine in the forced swim test
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5999402
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13 August 2018
What is hydroxynorketamine and what can it bring to neurotherapeutics?
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5999402
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13 August 2018
Differential effects of antidepressant drugs on mTOR signalling in rat hippocampal neurons.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5999402
retrieved
13 August 2018
Akt mediates GSK-3β phosphorylation in the rat prefrontal cortex during the process of ketamine exerting rapid antidepressant actions
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5999402
retrieved
13 August 2018
Ketamine-induced antidepressant effects are associated with AMPA receptors-mediated upregulation of mTOR and BDNF in rat hippocampus and prefrontal cortex
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5999402
retrieved
13 August 2018
Involvement of NMDA and AMPA receptors in the antidepressant-like activity of antidepressant drugs in the forced swim test
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5999402
retrieved
13 August 2018
Ketamine elicits sustained antidepressant-like activity via a serotonin-dependent mechanism.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5999402
retrieved
13 August 2018
Sex differences in the antidepressant-like effects of ketamine
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5999402
retrieved
13 August 2018
A critical role for GluN2B-containing NMDA receptors in cortical development and function.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5999402
retrieved
13 August 2018
Involvement of AMPA receptor in both the rapid and sustained antidepressant-like effects of ketamine in animal models of depression.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5999402
retrieved
13 August 2018
Transient inactivation of the infralimbic cortex induces antidepressant-like effects in the rat.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5999402
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13 August 2018
Comments on "An innovative design to establish proof of concept of the antidepressant effects of the NR2B subunit selective N-methyl-D-aspartate antagonist, CP-101,606 in patients with treatment-refractory major depressive disorder".
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5999402
retrieved
13 August 2018
The sigma enigma: can sigma receptors provide a novel target for disorders of mood and cognition?
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5999402
retrieved
13 August 2018
N-methyl-d-aspartic acid receptor antagonist-induced frequency oscillations in mice recreate pattern of electrophysiological deficits in schizophrenia
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5999402
retrieved
13 August 2018
Losing inhibition with ketamine
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5999402
retrieved
13 August 2018
N-methyl d-aspartate receptor antagonists ketamine and MK-801 induce wake-related aberrant gamma oscillations in the rat neocortex
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5999402
retrieved
13 August 2018
Acute administration of ketamine induces antidepressant-like effects in the forced swimming test and increases BDNF levels in the rat hippocampus
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5999402
retrieved
13 August 2018
Postsynaptic decoding of neural activity: eEF2 as a biochemical sensor coupling miniature synaptic transmission to local protein synthesis
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5999402
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13 August 2018
Cellular mechanisms underlying the antidepressant effects of ketamine: role of alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptors
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5999402
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13 August 2018
Lateral habenula stimulation inhibits rat midbrain dopamine neurons through a GABA(A) receptor-mediated mechanism.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5999402
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13 August 2018
An open-label, flexible-dose study of memantine in major depressive disorder.
1 reference
stated in
PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5999402
retrieved
13 August 2018
Pharmacologically diverse antidepressants rapidly activate brain-derived neurotrophic factor receptor TrkB and induce phospholipase-Cgamma signaling pathways in mouse brain.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5999402
retrieved
13 August 2018
Miniature neurotransmission stabilizes synaptic function via tonic suppression of local dendritic protein synthesis.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5999402
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13 August 2018
A double-blind, placebo-controlled study of memantine in the treatment of major depression
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5999402
retrieved
13 August 2018
Central administration of IGF-I and BDNF leads to long-lasting antidepressant-like effects
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5999402
retrieved
13 August 2018
Alpha 5 subunit-containing GABAA receptors affect the dynamic range of mouse hippocampal kainate-induced gamma frequency oscillations in vitro.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5999402
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13 August 2018
Regulation of dendritic protein synthesis by miniature synaptic events.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5999402
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13 August 2018
Gamma oscillations induced by kainate receptor activation in the entorhinal cortex in vitro.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5999402
retrieved
13 August 2018
Increased expression of the glial glutamate transporter EAAT2 modulates excitotoxicity and delays the onset but not the outcome of ALS in mice
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5999402
retrieved
13 August 2018
Adenylyl cyclase-dependent form of chemical long-term potentiation triggers translational regulation at the elongation step
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5999402
retrieved
13 August 2018
Activation of the TrkB neurotrophin receptor is induced by antidepressant drugs and is required for antidepressant-induced behavioral effects.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5999402
retrieved
13 August 2018
Brain-derived neurotrophic factor produces antidepressant effects in behavioral models of depression.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5999402
retrieved
13 August 2018
The glutamate synapse in neuropsychiatric disorders. Focus on schizophrenia and Alzheimer's disease.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5999402
retrieved
13 August 2018
Psychedelic effects of ketamine in healthy volunteers: relationship to steady-state plasma concentrations
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5999402
retrieved
13 August 2018
Norketamine, the main metabolite of ketamine, is a non-competitive NMDA receptor antagonist in the rat cortex and spinal cord.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5999402
retrieved
13 August 2018
Further characterization of [3H]ifenprodil binding to sigma receptors in rat brain.
1 reference
stated in
PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5999402
retrieved
13 August 2018
Adaptation of cortical but not hippocampal NMDA receptors after chronic citalopram treatment
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stated in
Crossref
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https://api.crossref.org/works/10.1038%2FMP.2017.255
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Serotonin-1A receptor stimulation mediates effects of a metabotropic glutamate 2/3 receptor antagonist, 2S-2-amino-2-(1S,2S-2-carboxycycloprop-1-yl)-3-(xanth-9-yl)propanoic acid (LY341495), and an N-methyl-D-aspartate receptor antagonist, ketamine,
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FMP.2017.255
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
In search of the mechanisms of ketamine’s antidepressant effects: How robust is the evidence behind the mTor activation hypothesis
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FMP.2017.255
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Ketamine – More mechanisms of action than just NMDA blockade
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FMP.2017.255
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Adaptation of the N-methyl-D-aspartate receptor complex following chronic antidepressant treatments
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/29532791
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Identifiers
DOI
10.1038/MP.2017.255
1 reference
stated in
Europe PubMed Central
PMC publication ID
5999402
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29532791%20AND%20SRC:MED&resulttype=core&format=json
retrieved
20 March 2020
PMC publication ID
5999402
1 reference
stated in
Europe PubMed Central
PMC publication ID
5999402
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29532791%20AND%20SRC:MED&resulttype=core&format=json
retrieved
20 March 2020
PubMed publication ID
29532791
1 reference
stated in
Europe PubMed Central
PMC publication ID
5999402
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29532791%20AND%20SRC:MED&resulttype=core&format=json
retrieved
20 March 2020
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