(Q53346702)

13 May 2018

title

Distinguishable effects of presenilin-1 and APP717 mutations on amyloid plaque deposition. (English)

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13 May 2018

Peter Henry St George-Hyslop

main subject

pollen

0 references

author

12

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13 May 2018

Lindsay A. Farrer

19

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13 May 2018

Péter Lantos

17

object named as

Lantos PL

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13 May 2018

author name string

Ishii K

1

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13 May 2018

Lippa C

2

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13 May 2018

Tomiyama T

3

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13 May 2018

Miyatake F

4

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13 May 2018

Ozawa K

5

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13 May 2018

Tamaoka A

6

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13 May 2018

Hasegawa T

7

1 reference

13 May 2018

Fraser PE

8

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13 May 2018

Shoji S

9

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13 May 2018

Nee LE

10

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13 May 2018

Pollen DA

11

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13 May 2018

Ii K

13

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13 May 2018

Ohtake T

14

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13 May 2018

Kalaria RN

15

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13 May 2018

Rossor MN

16

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13 May 2018

Cairns NJ

18

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13 May 2018

Mori H

20

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13 May 2018

publication date

1 May 2001

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13 May 2018

published in

Neurobiology of Aging

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13 May 2018

volume

22

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13 May 2018

issue

3

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13 May 2018

page(s)

367-376

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13 May 2018

Presenilin 1 protein directly interacts with Bcl-2

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Mutant presenilins of Alzheimer's disease increase production of 42-residue amyloid beta-protein in both transfected cells and transgenic mice

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Alzheimer's A beta(1-42) is generated in the endoplasmic reticulum/intermediate compartment of NT2N cells

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A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain

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7 January 2021

Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein

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Phosphorylation, subcellular localization, and membrane orientation of the Alzheimer's disease-associated presenilins.

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Clinicopathological features of familial Alzheimer's disease associated with the M139V mutation in the presenilin 1 gene. Pedigree but not mutation specific age at onset provides evidence for a further genetic factor.

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Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease

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7 January 2021

A novel presenilin-1 mutation: increased beta-amyloid and neurofibrillary changes.

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7 January 2021

Familial Alzheimer's disease in two kindreds of the same geographic and ethnic origin. A clinical and genetic study

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7 January 2021

Amyloid beta protein (A beta) in Alzheimer's disease brain. Biochemical and immunocytochemical analysis with antibodies specific for forms ending at A beta 40 or A beta 42(43).

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7 January 2021

Distinct sites of intracellular production for Alzheimer's disease A beta40/42 amyloid peptides.

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7 January 2021

Aggregation and secondary structure of synthetic amyloid beta A4 peptides of Alzheimer's disease.

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7 January 2021

Complete analysis of the presenilin 1 gene in early onset Alzheimer's disease.

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7 January 2021

The lack of accumulation of senile plaques or amyloid burden in Alzheimer's disease suggests a dynamic balance between amyloid deposition and resolution.

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7 January 2021

Presenilin 1 suppresses the function of c-Jun homodimers via interaction with QM/Jif-1

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7 January 2021

Increased A beta 42(43)-plaque deposition in early-onset familial Alzheimer's disease brains with the deletion of exon 9 and the missense point mutation (H163R) in the PS-1 gene.

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7 January 2021

Abeta1-40 but not Abeta1-42 levels in cortex correlate with apolipoprotein E epsilon4 allele dosage in sporadic Alzheimer's disease.

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7 January 2021

Amyloid beta protein (A beta) deposition: A beta 42(43) precedes A beta 40 in Down syndrome

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7 January 2021

Seeding "one-dimensional crystallization" of amyloid: a pathogenic mechanism in Alzheimer's disease and scrapie?

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7 January 2021

Three different mutations of presenilin 1 gene in early-onset Alzheimer's disease families

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7 January 2021

The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor

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7 January 2021

Familial Alzheimer's disease. A pedigree with a mis-sense mutation in the amyloid precursor protein gene (amyloid precursor protein 717 valine-->glycine).

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7 January 2021

Amyloid precursor protein mutation causes Alzheimer's disease in a Swedish family

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7 January 2021

Lewy bodies in the brain of two members of a family with the 717 (Val to Ile) mutation of the amyloid precursor protein gene.

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7 January 2021

The E280A presenilin 1 Alzheimer mutation produces increased A beta 42 deposition and severe cerebellar pathology.

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7 January 2021

A familial Alzheimer's disease locus on chromosome 1.

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7 January 2021

Mutation of a putative sperm membrane protein in Caenorhabditis elegans prevents sperm differentiation but not its associated meiotic divisions

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7 January 2021

Familial and sporadic Alzheimer's disease: neuropathology cannot exclude a final common pathway.

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7 January 2021

Amyloid beta protein (Abeta) deposition in chromosome 14-linked Alzheimer's disease: predominance of Abeta42(43).

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7 January 2021

Alzheimer's presenile dementia, senile dementia of Alzheimer type and Down's syndrome in middle age form an age related continuum of pathological changes

1 reference

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7 January 2021

Clinical comparison of Alzheimer's disease in pedigrees with the codon 717 Val→Ile mutation in the amyloid precursor protein gene

1 reference

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7 January 2021

A locus for familial early-onset Alzheimer's disease on the long arm of chromosome 14, proximal to the alpha 1-antichymotrypsin gene.

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7 January 2021

A family with histologically confirmed Alzheimer's disease.

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7 January 2021

Neurodegeneration induced by beta-amyloid peptides in vitro: the role of peptide assembly state

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7 January 2021

Enhancer function and novel DNA binding protein activity in the near upstream betaAPP gene promoter

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7 January 2021

Familial Alzheimer's disease in kindreds with missense mutations in a gene on chromosome 1 related to the Alzheimer's disease type 3 gene

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7 January 2021

Genetic linkage evidence for a familial Alzheimer's disease locus on chromosome 14

1 reference

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7 January 2021

Secreted amyloid beta-protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease

1 reference

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7 January 2021

Endogenous presenilin 1 redistributes to the surface of lamellipodia upon adhesion of Jurkat cells to a collagen matrix

1 reference

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7 January 2021

Amyloid beta-protein and the genetics of Alzheimer's disease

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7 January 2021

The role of APP processing and trafficking pathways in the formation of amyloid beta-protein

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7 January 2021

Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0197-4580%2801%2900216-0

7 January 2021

Genetic evidence for a novel familial Alzheimer's disease locus on chromosome 14.

1 reference

https://api.crossref.org/works/10.1016%2FS0197-4580%2801%2900216-0

7 January 2021

Hippocampal lesions in dominantly inherited Alzheimer's disease.

1 reference

https://api.crossref.org/works/10.1016%2FS0197-4580%2801%2900216-0

7 January 2021

An increased percentage of long amyloid beta protein secreted by familial amyloid beta protein precursor (beta APP717) mutants.

1 reference

https://api.crossref.org/works/10.1016%2FS0197-4580%2801%2900216-0

7 January 2021

Amyloid beta protein 1-42/43 (A beta 1-42/43) in cerebellar diffuse plaques: enzyme-linked immunosorbent assay and immunocytochemical study

1 reference

https://api.crossref.org/works/10.1016%2FS0197-4580%2801%2900216-0

7 January 2021

APOE genotype does not modulate age of onset in families with chromosome 14 encoded Alzheimer's disease.

1 reference

https://api.crossref.org/works/10.1016%2FS0197-4580%2801%2900216-0

7 January 2021

Mapping of a gene predisposing to early-onset Alzheimer's disease to chromosome 14q24.3

1 reference

https://api.crossref.org/works/10.1016%2FS0197-4580%2801%2900216-0

7 January 2021

Formation of stable complexes between two Alzheimer's disease gene products: presenilin-2 and beta-amyloid precursor protein

1 reference

https://api.crossref.org/works/10.1016%2FS0197-4580%2801%2900216-0

7 January 2021

Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity

1 reference

https://api.crossref.org/works/10.1016%2FS0197-4580%2801%2900216-0

7 January 2021

Interaction between amyloid precursor protein and presenilins in mammalian cells: implications for the pathogenesis of Alzheimer disease

1 reference

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7 January 2021

Identification of a novel PSD-95/Dlg/ZO-1 (PDZ)-like protein interacting with the C terminus of presenilin-1

1 reference

https://api.crossref.org/works/10.1016%2FS0197-4580%2801%2900216-0

7 January 2021

Neurogenic phenotypes and altered Notch processing in Drosophila Presenilin mutants.

1 reference

https://api.crossref.org/works/10.1016%2FS0197-4580%2801%2900216-0

7 January 2021

Nicastrin modulates presenilin-mediated notch/glp-1 signal transduction and betaAPP processing

1 reference

https://api.crossref.org/works/10.1016%2FS0197-4580%2801%2900216-0

7 January 2021

Evidence that A beta 42 is the real culprit in Alzheimer's disease.

1 reference

https://api.crossref.org/works/10.1016%2FS0197-4580%2801%2900216-0

7 January 2021

Presenilin 1 interaction in the brain with a novel member of the Armadillo family

1 reference

https://api.crossref.org/works/10.1016%2FS0197-4580%2801%2900216-0

7 January 2021

10.1016/S0197-4580(01)00216-0

Identifiers

DOI

1 reference

13 May 2018

1 reference

13 May 2018