(Q53347422)

English

Selective acetyl- and butyrylcholinesterase inhibitors reduce amyloid-β ex vivo activation of peripheral chemo-cytokines from Alzheimer's disease subjects: exploring the cholinergic anti-inflammatory pathway.

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scholarly article

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3 March 2020

Selective acetyl- and butyrylcholinesterase inhibitors reduce amyloid-β ex vivo activation of peripheral chemo-cytokines from Alzheimer's disease subjects: exploring the cholinergic anti-inflammatory pathway (English)

1 reference

Europe PubMed Central

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3 March 2020

Alzheimer's disease

1 reference

based on heuristic

inferred from title

Mohammad Amjad Kamal

7

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3 March 2020

Marta di Nicola

2

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3 March 2020

Chiara D'Angelo

4

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3 March 2020

Erica Costantini

5

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3 March 2020

author name string

Marcella Reale

1

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3 March 2020

Lucia Velluto

3

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3 March 2020

Debomoy K Lahiri

6

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3 March 2020

Qian-sheng Yu

8

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3 March 2020

Nigel H Greig

9

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3 March 2020

publication date

1 January 2014

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3 March 2020

Current Alzheimer Research

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3 March 2020

11

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3 March 2020

6

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3 March 2020

608-622

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Europe PubMed Central

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3 March 2020

The vagus nerve and the inflammatory reflex--linking immunity and metabolism

1 reference

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14 June 2018

Plasma acetylcholinesterase activity correlates with intracerebral β-amyloid load

1 reference

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14 June 2018

Pathogenesis of Abeta oligomers in synaptic failure.

1 reference

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14 June 2018

Longitudinal epidemiologic clinical-pathologic studies of aging and Alzheimer's disease

1 reference

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14 June 2018

Tumor necrosis factor-α synthesis inhibitor 3,6'-dithiothalidomide attenuates markers of inflammation, Alzheimer pathology and behavioral deficits in animal models of neuroinflammation and Alzheimer's disease

1 reference

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14 June 2018

Regulatory mechanisms of acetylcholine synthesis and release by T cells

1 reference

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14 June 2018

Relationship between inflammatory mediators, Aβ levels and ApoE genotype in Alzheimer disease

1 reference

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14 June 2018

Neuronal receptors as targets for the action of amyloid-beta protein (Aβ) in the brain

1 reference

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14 June 2018

Modulation of inflammatory pathways by the immune cholinergic system.

1 reference

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14 June 2018

α7 nicotinic acetylcholine receptor (α7nAChR) expression in bone marrow-derived non-T cells is required for the inflammatory reflex.

1 reference

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14 June 2018

Cholinergic modulation of amyloid precursor protein processing with emphasis on M1 muscarinic receptor: perspectives and challenges in treatment of Alzheimer's disease

1 reference

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14 June 2018

Neuroinflammation and tumor necrosis factor signaling in the pathophysiology of Alzheimer's disease.

1 reference

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14 June 2018

Peripheral blood mono-nuclear cells derived from Alzheimer's disease patients show elevated baseline levels of secreted cytokines but resist stimulation with β-amyloid peptide.

1 reference

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14 June 2018

The molecular assembly of amyloid aβ controls its neurotoxicity and binding to cellular proteins

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5947847

14 June 2018

Acetylcholine-synthesizing T cells relay neural signals in a vagus nerve circuit

1 reference

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14 June 2018

Functional activity of the novel Alzheimer's amyloid β-peptide interacting domain (AβID) in the APP and BACE1 promoter sequences and implications in activating apoptotic genes and in amyloidogenesis

1 reference

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14 June 2018

The Alzheimer's amyloid β-peptide (Aβ) binds a specific DNA Aβ-interacting domain (AβID) in the APP, BACE1, and APOE promoters in a sequence-specific manner: characterizing a new regulatory motif

1 reference

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14 June 2018

Does a pro-inflammatory process precede Alzheimer's disease and mild cognitive impairment?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5947847

14 June 2018

Targeting TNF-α to elucidate and ameliorate neuroinflammation in neurodegenerative diseases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5947847

14 June 2018

Altered levels of acetylcholinesterase in Alzheimer plasma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5947847

14 June 2018

The history of the cholinergic hypothesis

1 reference

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14 June 2018

Neuroprotective and neurotoxic effects of nicotine

1 reference

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14 June 2018

Biological markers of amyloid beta-related mechanisms in Alzheimer's disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5947847

14 June 2018

Microglial activation in Alzheimer's disease.

1 reference

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14 June 2018

Systemic inflammation and disease progression in Alzheimer disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5947847

14 June 2018

Amyloid-beta(1-42) fibrillar precursors are optimal for inducing tumor necrosis factor-alpha production in the THP-1 human monocytic cell line

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5947847

14 June 2018

Cholinesterase inhibition: is there evidence for disease-modifying effects?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5947847

14 June 2018

Clearance of amyloid-beta peptide across the blood-brain barrier: implication for therapies in Alzheimer's disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5947847

14 June 2018

Splenic nerve is required for cholinergic antiinflammatory pathway control of TNF in endotoxemia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5947847

14 June 2018

Structure-function relationships of pre-fibrillar protein assemblies in Alzheimer's disease and related disorders

1 reference

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14 June 2018

Structure-function implications in Alzheimer's disease: effect of Abeta oligomers at central synapses

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5947847

14 June 2018

The role of interleukin-1 in neuroinflammation and Alzheimer disease: an evolving perspective

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5947847

14 June 2018

Discovery of ADDL--targeting small molecule drugs for Alzheimer's disease

1 reference

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14 June 2018

TNF-alpha inhibition as a treatment strategy for neurodegenerative disorders: new drug candidates and targets.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5947847

14 June 2018

Blood-brain barrier: ageing and microvascular disease--systematic review and meta-analysis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5947847

14 June 2018

Excessive hippocampal acetylcholine levels in acetylcholinesterase-deficient mice are moderated by butyrylcholinesterase activity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5947847

14 June 2018

An internally controlled peripheral biomarker for Alzheimer's disease: Erk1 and Erk2 responses to the inflammatory signal bradykinin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5947847

14 June 2018

Has the amyloid cascade hypothesis for Alzheimer's disease been proved?

1 reference

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14 June 2018

Selective butyrylcholinesterase inhibition elevates brain acetylcholine, augments learning and lowers Alzheimer beta-amyloid peptide in rodent

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5947847

14 June 2018

Nicotinic effects on cognitive function: behavioral characterization, pharmacological specification, and anatomic localization

1 reference

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14 June 2018

Targeting acetylcholinesterase and butyrylcholinesterase in dementia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5947847

14 June 2018

An overview of phenserine tartrate, a novel acetylcholinesterase inhibitor for the treatment of Alzheimer's disease

1 reference

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14 June 2018

LY294002 inhibits LPS-induced NO production through a inhibition of NF-kappaB activation: independent mechanism of phosphatidylinositol 3-kinase

1 reference

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14 June 2018

Rationale for the development of cholinesterase inhibitors as anti-Alzheimer agents.

1 reference

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14 June 2018

LRP/amyloid beta-peptide interaction mediates differential brain efflux of Abeta isoforms.

1 reference

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14 June 2018

The lymphocytic cholinergic system and its contribution to the regulation of immune activity

1 reference

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14 June 2018

A new and rapid colorimetric determination of acetylcholinesterase activity

1 reference

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14 June 2018

Amyloid Peptide-Induced Cytokine and Chemokine Expression in THP-1 Monocytes Is Blocked by Small Inhibitory RNA Duplexes for Early Growth Response-1 Messenger RNA

1 reference

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14 June 2018

The lymphocytic cholinergic system and its biological function

1 reference

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14 June 2018

Neurobiology of butyrylcholinesterase.

1 reference

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14 June 2018

Nicotinic acetylcholine receptor alpha7 subunit is an essential regulator of inflammation

1 reference

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14 June 2018

Advances in the cellular and molecular biology of the beta-amyloid protein in Alzheimer's disease

1 reference

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14 June 2018

A new therapeutic target in Alzheimer's disease treatment: attention to butyrylcholinesterase

1 reference

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14 June 2018

Regulation of beta-amyloid stimulated proinflammatory responses by peroxisome proliferator-activated receptor alpha

1 reference

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14 June 2018

Peripheral anti-A beta antibody alters CNS and plasma A beta clearance and decreases brain A beta burden in a mouse model of Alzheimer's disease

1 reference

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14 June 2018

Phenserine regulates translation of beta -amyloid precursor protein mRNA by a putative interleukin-1 responsive element, a target for drug development

1 reference

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14 June 2018

beta-Amyloid stimulation of microglia and monocytes results in TNFalpha-dependent expression of inducible nitric oxide synthase and neuronal apoptosis.

1 reference

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14 June 2018

Clearance of Alzheimer's amyloid-ss(1-40) peptide from brain by LDL receptor-related protein-1 at the blood-brain barrier

1 reference

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14 June 2018

Vagus nerve stimulation attenuates the systemic inflammatory response to endotoxin

1 reference

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14 June 2018

Amyloid beta and amylin fibrils induce increases in proinflammatory cytokine and chemokine production by THP-1 cells and murine microglia

1 reference

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14 June 2018

The secretion of amyloid beta-peptides is inhibited in the tacrine-treated human neuroblastoma cells.

1 reference

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14 June 2018

Amyloid-beta induces chemokine secretion and monocyte migration across a human blood--brain barrier model

1 reference

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14 June 2018

Peripheral markers in testing pathophysiological hypotheses and diagnosing Alzheimer's disease

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14 June 2018

Nicotinic receptor stimulation protects neurons against beta-amyloid toxicity.

1 reference

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14 June 2018

Selective phosphorylation of adult tau isoforms in mature hippocampal neurons exposed to fibrillar A beta.

1 reference

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14 June 2018

Hematopoietic cells differentiate into both microglia and macroglia in the brains of adult mice

1 reference

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14 June 2018

Interaction of Alzheimer beta-amyloid peptide with the human monocytic cell line THP-1 results in a protein kinase C-dependent secretion of tumor necrosis factor-alpha

1 reference

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14 June 2018

Tacrine alters the secretion of the beta-amyloid precursor protein in cell lines

1 reference

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14 June 2018

The cholinesterases: from genes to proteins

1 reference

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14 June 2018

Phenserine and ring C hetero-analogues: drug candidates for the treatment of Alzheimer's disease

1 reference

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14 June 2018

Vector-mediated delivery of 125I-labeled beta-amyloid peptide A beta 1-40 through the blood-brain barrier and binding to Alzheimer disease amyloid of the A beta 1-40/vector complex

1 reference

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14 June 2018

The cholinergic hypothesis of geriatric memory dysfunction

1 reference

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14 June 2018

Clinical diagnosis of Alzheimer's disease: report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease

1 reference

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14 June 2018

Changes in brain cholinesterases in senile dementia of Alzheimer type.

1 reference

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14 June 2018

Inflammation in Alzheimer disease-a brief review of the basic science and clinical literature

1 reference

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16 June 2018

Cholinesterase inhibitors and beyond

1 reference

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16 June 2018

The alpha7 nicotinic acetylcholine receptor as a pharmacological target for inflammation.

1 reference

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16 June 2018

A partial failure of membrane protein turnover may cause Alzheimer's disease: a new hypothesis.

1 reference

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16 June 2018

Non-steroidal anti-inflammatory drugs (NSAIDs) and other anti-inflammatory agents in the treatment of neurodegenerative disease

1 reference

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16 June 2018

Cholinesterases: roles in the brain during health and disease.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5947847

16 June 2018

The amyloid-beta peptide suppresses transforming growth factor-beta1-induced matrix metalloproteinase-2 production via Smad7 expression in human monocytic THP-1 cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5947847

16 June 2018

Acetylcholinesterase and its inhibition in Alzheimer disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5947847

16 June 2018

Systemic inflammation and Alzheimer's disease.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5947847

13 August 2018

Peripheral chemokine receptors, their ligands, cytokines and Alzheimer's disease.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5947847

13 August 2018

N1phenethyl-norcymserine, a selective butyrylcholinesterase inhibitor, increases acetylcholine release in rat cerebral cortex: a comparison with donepezil and rivastigmine.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5947847

13 August 2018

Elevated butyrylcholinesterase and acetylcholinesterase may predict the development of type 2 diabetes mellitus and Alzheimer's disease.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5947847

13 August 2018

Acetylcholinesterase inhibitors for Alzheimer's disease: anti-inflammatories in acetylcholine clothing!

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5947847

13 August 2018

The acetylcholinesterase inhibitor, Donepezil, regulates a Th2 bias in Alzheimer's disease patients.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5947847

13 August 2018

Memory deficits correlating with acetylcholinesterase splice shift and amyloid burden in doubly transgenic mice.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5947847

13 August 2018

Regulation of CD8+ cytolytic T lymphocyte differentiation by a cholinergic pathway

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5947847

13 August 2018

PI3K-Akt pathway suppresses coagulation and inflammation in endotoxemic mice.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5947847

13 August 2018

Cholinergic modulation of microglial activation by alpha 7 nicotinic receptors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5947847

13 August 2018

Modulation of the phosphoinositide 3-kinase pathway alters innate resistance to polymicrobial sepsis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5947847

13 August 2018

Amyloid-beta increases acetylcholinesterase expression in neuroblastoma cells by reducing enzyme degradation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5947847

13 August 2018

RAGE mediates amyloid-beta peptide transport across the blood-brain barrier and accumulation in brain

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5947847

13 August 2018

Role of cytokines in the gene expression of amyloid β–protein precursor: Identification of a 5'-UTR-Binding nuclear factor and its implications in Alzheimer's disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5947847

13 August 2018

Transforming growth factor-beta 1 potentiates amyloid-beta generation in astrocytes and in transgenic mice.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5947847

13 August 2018

Phosphatidylinositol 3-kinase is involved in Toll-like receptor 4-mediated cytokine expression in mouse macrophages

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5947847

13 August 2018

Chronic nicotine treatment reduces beta-amyloidosis in the brain of a mouse model of Alzheimer's disease (APPsw).

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5947847

13 August 2018

Synthesis of novel phenserine-based-selective inhibitors of butyrylcholinesterase for Alzheimer's disease.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5947847

13 August 2018

Cerebrovascular accumulation and increased blood-brain barrier permeability to circulating Alzheimer's amyloid beta peptide in aged squirrel monkey with cerebral amyloid angiopathy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5947847

13 August 2018

Effects of cholinesterase inhibitors on the secretion of beta-amyloid precursor protein in cell cultures.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5947847

13 August 2018

Amyloid beta neurotoxicity not mediated by the mitogen-activated protein kinase cascade in cultured rat hippocampal and cortical neurons

1 reference

https://pubmed.ncbi.nlm.nih.gov/24359497

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Association between butyrylcholinesterase activity and low-grade systemic inflammation

1 reference

https://pubmed.ncbi.nlm.nih.gov/24359497

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

PD98059 prevents neurite degeneration induced by fibrillar beta-amyloid in mature hippocampal neurons

1 reference

https://pubmed.ncbi.nlm.nih.gov/24359497

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

All-or-nothing type biphasic cytokine production of human lymphocytes after exposure to Alzheimer's beta-amyloid peptide

1 reference

https://pubmed.ncbi.nlm.nih.gov/24359497

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The non-neuronal cholinergic system: basic science, therapeutic implications and new perspectives

1 reference

https://pubmed.ncbi.nlm.nih.gov/24359497

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Plasma amyloid beta protein is elevated in late-onset Alzheimer disease families

1 reference

https://pubmed.ncbi.nlm.nih.gov/24359497

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.2174/1567205010666131212113218

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24359497%20AND%20SRC:MED&resulttype=core&format=json

3 March 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24359497%20AND%20SRC:MED&resulttype=core&format=json

3 March 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24359497%20AND%20SRC:MED&resulttype=core&format=json

3 March 2020

ResearchGate publication ID

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