(Q37961834)

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Cholinergic modulation of amyloid precursor protein processing with emphasis on M1 muscarinic receptor: perspectives and challenges in treatment of Alzheimer's disease

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scholarly article

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Europe PubMed Central

26 August 2017

Cholinergic modulation of amyloid precursor protein processing with emphasis on M1 muscarinic receptor: perspectives and challenges in treatment of Alzheimer's disease (English)

1 reference

Europe PubMed Central

26 August 2017

Alzheimer's disease

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author name string

Abraham Fisher

1

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Europe PubMed Central

26 August 2017

language of work or name

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publication date

28 November 2011

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Europe PubMed Central

26 August 2017

Journal of Neurochemistry

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Europe PubMed Central

26 August 2017

120 Suppl 1

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Europe PubMed Central

26 August 2017

22-33

1 reference

Europe PubMed Central

26 August 2017

A neurochemical approach for studying response to acetylcholine in Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2011.07507.X

21 January 2018

Selective cognitive dysfunction in acetylcholine M1 muscarinic receptor mutant mice

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2011.07507.X

21 January 2018

Alzheimer's disease and the basal forebrain cholinergic system: relations to beta-amyloid peptides, cognition, and treatment strategies

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2011.07507.X

21 January 2018

Glycogen synthase kinase 3beta and Alzheimer's disease: pathophysiological and therapeutic significance

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2011.07507.X

21 January 2018

Cholinesterase inhibitors reduce cortical Abeta in dementia with Lewy bodies.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2011.07507.X

21 January 2018

On neurodegenerative diseases, models, and treatment strategies: lessons learned and lessons forgotten a generation following the cholinergic hypothesis

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2011.07507.X

21 January 2018

Reduction of cerebrospinal fluid amyloid beta after systemic administration of M1 muscarinic agonists

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2011.07507.X

21 January 2018

Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2011.07507.X

21 January 2018

Effects of xanomeline, a selective muscarinic receptor agonist, on cognitive function and behavioral symptoms in Alzheimer disease

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2011.07507.X

21 January 2018

Efficacy and safety of memantine in moderate-to-severe Alzheimer disease: the evidence to date

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2011.07507.X

21 January 2018

M1 receptors play a central role in modulating AD-like pathology in transgenic mice

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2011.07507.X

21 January 2018

Nerve growth factor and galantamine ameliorate early signs of neurodegeneration in anti-nerve growth factor mice.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2011.07507.X

21 January 2018

Ganstigmine and donepezil improve neurodegeneration in AD11 antinerve growth factor transgenic mice

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2011.07507.X

21 January 2018

Cholinesterase inhibitors may increase phosphorylated tau in Alzheimer's disease.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2011.07507.X

21 January 2018

Alzheimer's disease: A prion protein connection.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2011.07507.X

21 January 2018

M1 and M3 muscarinic receptors control physiological processing of cellular prion by modulating ADAM17 phosphorylation and activity.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2011.07507.X

21 January 2018

ERK1-independent α-secretase cut of β-amyloid precursor protein via M1 muscarinic receptors and PKCα/ε.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2011.07507.X

21 January 2018

Ablation of cellular prion protein does not ameliorate abnormal neural network activity or cognitive dysfunction in the J20 line of human amyloid precursor protein transgenic mice

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2011.07507.X

21 January 2018

Muscarinic receptor agonists and antagonists in the treatment of Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2011.07507.X

21 January 2018

Galantamine, a cholinesterase inhibitor that allosterically modulates nicotinic receptors: effects on the course of Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2011.07507.X

21 January 2018

Deletion of M1 muscarinic acetylcholine receptors increases amyloid pathology in vitro and in vivo

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2011.07507.X

21 January 2018

Effects of donepezil on amyloid-beta and synapse density in the Tg2576 mouse model of Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2011.07507.X

21 January 2018

Deletion of the alpha 7 nicotinic acetylcholine receptor gene improves cognitive deficits and synaptic pathology in a mouse model of Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2011.07507.X

21 January 2018

BACE inhibitors as potential drugs for the treatment of Alzheimer's disease: focus on bioactivity

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2011.07507.X

21 January 2018

Alzheimer's failure raises questions about disease-modifying strategies

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2011.07507.X

21 January 2018

Attenuation of muscarinic receptor-G-protein interaction in Alzheimer disease

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2011.07507.X

21 January 2018

Therapeutic strategies in Alzheimer's disease: M1 muscarinic agonists

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2011.07507.X

21 January 2018

Cholinergic treatments with emphasis on m1 muscarinic agonists as potential disease-modifying agents for Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2011.07507.X

21 January 2018

AF150(S) and AF267B: M1 muscarinic agonists as innovative therapies for Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2011.07507.X

21 January 2018

Muscarinic agonists reduce tau phosphorylation in non-neuronal cells via GSK-3beta inhibition and in neurons.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2011.07507.X

21 January 2018

β-amyloid oligomers and prion protein: Fatal attraction?

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2011.07507.X

21 January 2018

Use of muscarinic agonists in the treatment of Sjögren's syndrome

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2011.07507.X

21 January 2018

Memory impairment in transgenic Alzheimer mice requires cellular prion protein

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2011.07507.X

21 January 2018

Selective butyrylcholinesterase inhibition elevates brain acetylcholine, augments learning and lowers Alzheimer beta-amyloid peptide in rodent

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2011.07507.X

21 January 2018

Activation of muscarinic receptors inhibits beta-amyloid peptide-induced signaling in cortical slices.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2011.07507.X

21 January 2018

The alpha-secretase-derived N-terminal product of cellular prion, N1, displays neuroprotective function in vitro and in vivo

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2011.07507.X

21 January 2018

The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2011.07507.X

21 January 2018

Pharmacological comparison of muscarinic ligands: historical versus more recent muscarinic M1-preferring receptor agonists

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2011.07507.X

21 January 2018

Treatment with the selective muscarinic m1 agonist talsaclidine decreases cerebrospinal fluid levels of A beta 42 in patients with Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2011.07507.X

21 January 2018

Role of GSK-3beta activation and alpha7 nAChRs in Abeta(1-42)-induced tau phosphorylation in PC12 cells

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2011.07507.X

21 January 2018

Cell biology, regulation and inhibition of beta-secretase (BACE-1).

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2011.07507.X

21 January 2018

An adaptive first in man dose-escalation study of NGX267: statistical, clinical, and operational considerations

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2011.07507.X

21 January 2018

Novel selective allosteric activator of the M1 muscarinic acetylcholine receptor regulates amyloid processing and produces antipsychotic-like activity in rats.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2011.07507.X

21 January 2018

Amyloid beta-peptide disrupts carbachol-induced muscarinic cholinergic signal transduction in cortical neurons.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2011.07507.X

21 January 2018

Loss of inositol 1,4,5-trisphosphate receptor sites and decreased PKC levels correlate with staging of Alzheimer's disease neurofibrillary pathology.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2011.07507.X

21 January 2018

Characterization of a CNS penetrant, selective M1 muscarinic receptor agonist, 77-LH-28-1

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2011.07507.X

21 January 2018

Cellular prion protein mediates impairment of synaptic plasticity by amyloid-beta oligomers

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2011.07507.X

21 January 2018

Amyloid beta peptide load is correlated with increased beta-secretase activity in sporadic Alzheimer's disease patients

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2011.07507.X

21 January 2018

α-secretase in Alzheimer's disease: molecular identity, regulation and therapeutic potential

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2011.07507.X

21 January 2018

Muscarinic acetylcholine receptor inhibition in transgenic Alzheimer-like Tg2576 mice by scopolamine favours the amyloidogenic route of processing of amyloid precursor protein

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2011.07507.X

21 January 2018

Loss of muscarinic M1 receptor exacerbates Alzheimer's disease-like pathology and cognitive decline

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2011.07507.X

21 January 2018

Nicotinic receptor agonists and antagonists increase sAPPalpha secretion and decrease Abeta levels in vitro

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2011.07507.X

21 January 2018

Alzheimer's disease-do tauists and baptists finally shake hands?

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2011.07507.X

21 January 2018

Loss of muscarinic M4 receptors in hippocampus of Alzheimer patients

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2011.07507.X

21 January 2018

From acetylcholine to amyloid: neurotransmitters and the pathology of Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2011.07507.X

21 January 2018

Release of Alzheimer amyloid precursor derivatives stimulated by activation of muscarinic acetylcholine receptors

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2011.07507.X

21 January 2018

Chronic nicotine treatment reduces beta-amyloidosis in the brain of a mouse model of Alzheimer's disease (APPsw).

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2011.07507.X

21 January 2018

Triple-transgenic model of Alzheimer's disease with plaques and tangles: intracellular Abeta and synaptic dysfunction

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2011.07507.X

21 January 2018

Chronic nicotine administration exacerbates tau pathology in a transgenic model of Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2011.07507.X

21 January 2018

Alzheimer's disease amyloid beta-protein and synaptic function

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2011.07507.X

21 January 2018

Cortical M1 receptor concentration increases without a concomitant change in function in Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2011.07507.X

21 January 2018

Cerebrospinal fluid levels of biomarkers and activity of acetylcholinesterase (AChE) and butyrylcholinesterase in AD patients before and after treatment with different AChE inhibitors.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2011.07507.X

21 January 2018

Increased Alzheimer pathology in Parkinson's disease related to antimuscarinic drugs.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2011.07507.X

21 January 2018

Muscarinic control of amyloid precursor protein secretion in rat cerebral cortex and cerebellum.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2011.07507.X

21 January 2018

Lesion of septal-hippocampal neurons with 192 IgG-saporin alters function of M1 muscarinic receptors.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2011.07507.X

21 January 2018

Pre- and post-synaptic cortical cholinergic deficits are proportional to amyloid plaque presence and density at preclinical stages of Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2011.07507.X

21 January 2018

Acetylcholinesterase inhibitors: novel activities of old molecules.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2011.07507.X

21 January 2018

Discovery and optimization of a novel, selective and brain penetrant M1 positive allosteric modulator (PAM): the development of ML169, an MLPCN probe

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2011.07507.X

21 January 2018

alpha7 Nicotinic receptor gene delivery into mouse hippocampal neurons leads to functional receptor expression, improved spatial memory-related performance, and tau hyperphosphorylation

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2011.07507.X

21 January 2018

Current and emerging pharmacological treatment options for dementia

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2011.07507.X

21 January 2018

Impaired attention in the 3xTgAD mouse model of Alzheimer's disease: rescue by donepezil (Aricept).

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2011.07507.X

21 January 2018

Absence of effect of chronic nicotine administration on amyloid beta peptide levels in transgenic mice overexpressing mutated human APP (Sw, Ind).

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2011.07507.X

21 January 2018

Discovery of N-{1-[3-(3-oxo-2,3-dihydrobenzo[1,4]oxazin-4-yl)propyl]piperidin-4-yl}-2-phenylacetamide (Lu AE51090): an allosteric muscarinic M1 receptor agonist with unprecedented selectivity and procognitive potential.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2011.07507.X

21 January 2018

The cholinergic system in aging and neuronal degeneration

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2011.07507.X

21 January 2018

Beyond amyloid: the next generation of Alzheimer's disease therapeutics.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2011.07507.X

21 January 2018

A selective allosteric potentiator of the M1 muscarinic acetylcholine receptor increases activity of medial prefrontal cortical neurons and restores impairments in reversal learning

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2011.07507.X

21 January 2018

Structural requirements of transmembrane domain 3 for activation by the M1 muscarinic receptor agonists AC-42, AC-260584, clozapine, and N-desmethylclozapine: evidence for three distinct modes of receptor activation

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2011.07507.X

21 January 2018

Tacrine and donepezil attenuate the neurotoxic effect of A beta(25-35) in rat PC12 cells.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2011.07507.X

21 January 2018

Characterization of muscarinic receptor subtypes in Alzheimer and control brain cortices by selective muscarinic antagonists

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2011.07507.X

21 January 2018

The role of G protein-coupled receptors in the pathology of Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2011.07507.X

21 January 2018

Impaired coupling of muscarinic M1 receptors to G-proteins in the neocortex is associated with severity of dementia in Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2011.07507.X

21 January 2018

alpha- and beta-secretase: profound changes in Alzheimer's disease.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2011.07507.X

21 January 2018

Effect of subchronic treatment of memantine, galantamine, and nicotine in the brain of Tg2576 (APPswe) transgenic mice

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2011.07507.X

21 January 2018

Symptomatic effect of donepezil, rivastigmine, galantamine and memantine on cognitive deficits in the APP23 model.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2011.07507.X

21 January 2018

Muscarinic acetylcholine receptor subtypes in cerebral cortex and hippocampus

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2011.07507.X

21 January 2018

Altered hippocampal muscarinic receptors in acetylcholinesterase-deficient mice

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2011.07507.X

21 January 2018

Transmembrane signaling through phospholipase C in human cortical membranes.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2011.07507.X

21 January 2018

Alpha 7 nicotinic acetylcholine receptors mediate beta-amyloid peptide-induced tau protein phosphorylation

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2011.07507.X

21 January 2018

Muscarinic acetylcholine receptors: mutant mice provide new insights for drug development

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2011.07507.X

21 January 2018

Muscarinic regulation of Alzheimer's disease amyloid precursor protein secretion and amyloid beta-protein production in human neuronal NT2N cells

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2011.07507.X

21 January 2018

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10.1111/J.1471-4159.2011.07507.X

1 reference

Europe PubMed Central

26 August 2017

1 reference

Europe PubMed Central

26 August 2017

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