(Q37830311)

24 August 2017

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title

The role of G protein-coupled receptors in the pathology of Alzheimer's disease (English)

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G protein-coupled receptor

24 August 2017

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2

Bart De Strooper

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24 August 2017

Amantha Thathiah

1

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PubMed ID

21248787

24 August 2017

language of work or name

English

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publication date

1 February 2011

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Nature Reviews Neuroscience

24 August 2017

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24 August 2017

12

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24 August 2017

2

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24 August 2017

73-87

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https://scigraph.springernature.com/pub.10.1038/nrn2977

24 August 2017

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Selective cognitive dysfunction in acetylcholine M1 muscarinic receptor mutant mice

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31 March 2020

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31 March 2020

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31 March 2020

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31 March 2020

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31 March 2020

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Impaired metabotropic glutamate receptor/phospholipase C signaling pathway in the cerebral cortex in Alzheimer's disease and dementia with Lewy bodies correlates with stage of Alzheimer's-disease-related changes

31 March 2020

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Aberrant expression of metabotropic glutamate receptor 2 in the vulnerable neurons of Alzheimer's disease

31 March 2020

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31 March 2020

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Quantitative mRNA analysis of five C-terminal splice variants of the human 5-HT4 receptor in the central nervous system by TaqMan real time RT-PCR.

31 March 2020

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5-HT4 receptor agonists increase sAPPalpha levels in the cortex and hippocampus of male C57BL/6j mice

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Activation of 5-HT4 receptors inhibits secretion of beta-amyloid peptides and increases neuronal survival

31 March 2020

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5-Hydroxytryptamine (5-HT)4 receptors in post mortem human brain tissue: distribution, pharmacology and effects of neurodegenerative diseases

31 March 2020

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A novel rat serotonin (5-HT6) receptor: molecular cloning, localization and stimulation of cAMP accumulation

31 March 2020

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Cloning, characterization, and chromosomal localization of a human 5-HT6 serotonin receptor

31 March 2020

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The 5-HT6 Receptor Antagonist SB-271046 Reverses Scopolamine-Disrupted Consolidation of a Passive Avoidance Task and Ameliorates Spatial Task Deficits in Aged Rats

31 March 2020

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The serotonin 5-HT6 receptor: a viable drug target for treating cognitive deficits in Alzheimer's disease

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Association analysis of the 5-HT6 receptor polymorphism C267T in Alzheimer's disease.

31 March 2020

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Serotonin 5-HT2A and 5-HT6 receptors in the prefrontal cortex of Alzheimer and normal aging patients

31 March 2020

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Corticotropin-releasing factor-like immunoreactivity in senile dementia of the Alzheimer type. Reduced cortical and striatal concentrations.

31 March 2020

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Reciprocal changes in corticotropin-releasing factor (CRF)-like immunoreactivity and CRF receptors in cerebral cortex of Alzheimer's disease

31 March 2020

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CSF corticotropin-releasing factor (CRF) in Alzheimer's disease: its relationship to severity of dementia and monoamine metabolites

31 March 2020

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Displacement of corticotropin releasing factor from its binding protein as a possible treatment for Alzheimer's disease

31 March 2020

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Distribution of vasoactive intestinal peptide and pituitary adenylate cyclase-activating polypeptide receptors (VPAC1, VPAC2, and PAC1 receptor) in the rat brain

31 March 2020

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Pituitary adenylate cyclase-activating polypeptide hormone (PACAP) at very low dosages improves memory in the rat.

31 March 2020

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The neuropeptide PACAP promotes the alpha-secretase pathway for processing the Alzheimer amyloid precursor protein

31 March 2020

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Passage of VIP/PACAP/secretin family across the blood-brain barrier: therapeutic effects

31 March 2020

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The beta-secretase enzyme BACE in health and Alzheimer's disease: regulation, cell biology, function, and therapeutic potential

31 March 2020

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The secretases: enzymes with therapeutic potential in Alzheimer disease

31 March 2020

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A GPCR/secretase complex regulates beta- and gamma-secretase specificity for Abeta production and contributes to AD pathogenesis.

31 March 2020

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Mu-, delta- and kappa-opioid receptor populations are differentially altered in distinct areas of postmortem brains of Alzheimer's disease patients

31 March 2020

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Activation of beta2-adrenergic receptor stimulates gamma-secretase activity and accelerates amyloid plaque formation.

31 March 2020

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Enkephalin elevations contribute to neuronal and behavioral impairments in a transgenic mouse model of Alzheimer's disease

31 March 2020

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Neuropeptide alterations in the hippocampal formation and cortex of transgenic mice overexpressing beta-amyloid precursor protein (APP) with the Swedish double mutation (APP23).

31 March 2020

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Cellular and synaptic adaptations mediating opioid dependence.

31 March 2020

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31 March 2020

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31 March 2020

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Aph-1, Pen-2, and Nicastrin with Presenilin generate an active gamma-Secretase complex

31 March 2020

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Subcellular topography of neuronal Abeta peptide in APPxPS1 transgenic mice

31 March 2020

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Presenilin-1, Nicastrin, Amyloid Precursor Protein, and γ-Secretase Activity Are Co-localized in the Lysosomal Membrane

31 March 2020

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Adrenergic receptors in aging and Alzheimer's disease: increased beta 2-receptors in prefrontal cortex and hippocampus

31 March 2020

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Polymorphisms at the beta2-adrenergic receptor gene influence Alzheimer's disease susceptibility.

31 March 2020

1 reference

Sphingosine 1-phosphate is a ligand of the human gpr3, gpr6 and gpr12 family of constitutively active G protein-coupled receptors

31 March 2020

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The orphan G protein-coupled receptor 3 modulates amyloid-beta peptide generation in neurons

31 March 2020

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GPR3 receptor, a novel actor in the emotional-like responses

31 March 2020

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Isolation and chromosomal localization of a novel human G-protein-coupled receptor (GPR3) expressed predominantly in the central nervous system

31 March 2020

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Neural expression of G protein-coupled receptors GPR3, GPR6, and GPR12 up-regulates cyclic AMP levels and promotes neurite outgrowth

31 March 2020

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Abeta42-driven cerebral amyloidosis in transgenic mice reveals early and robust pathology

31 March 2020

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Novel role of CXCR2 in regulation of gamma-secretase activity

31 March 2020

1 reference

Depletion of CXCR2 inhibits γ-secretase activity and amyloid-β production in a murine model of Alzheimer's disease.

31 March 2020

1 reference

Tumor necrosis factor-alpha, interleukin-1beta, and interferon-gamma stimulate gamma-secretase-mediated cleavage of amyloid precursor protein through a JNK-dependent MAPK pathway

31 March 2020

1 reference

Tumor necrosis factor-alpha-elicited stimulation of gamma-secretase is mediated by c-Jun N-terminal kinase-dependent phosphorylation of presenilin and nicastrin

31 March 2020

1 reference

Diffusible, nonfibrillar ligands derived from Abeta1-42 are potent central nervous system neurotoxins

31 March 2020

1 reference

Effects on blood pressure and exploratory behaviour of mice lacking angiotensin II type-2 receptor

31 March 2020

1 reference

The angiotensin II AT2 receptor is an AT1 receptor antagonist.

31 March 2020

1 reference

Diminished muscarinic receptor-stimulated [3H]-PIP2 hydrolysis in Alzheimer's disease

31 March 2020

1 reference

Impaired coupling of muscarinic M1 receptors to G-proteins in the neocortex is associated with severity of dementia in Alzheimer's disease

31 March 2020

1 reference

Angiotensin II AT2 receptor oligomers mediate G-protein dysfunction in an animal model of Alzheimer disease.

31 March 2020

1 reference

G protein-coupled receptors, cholinergic dysfunction, and Abeta toxicity in Alzheimer's disease

31 March 2020

1 reference

A1 Adenosine Receptors Accumulate in Neurodegenerative Structures in Alzheimer's Disease and Mediate Both Amyloid Precursor Protein Processing and Tau Phosphorylation and Translocation

31 March 2020

1 reference

Up-regulation of adenosine receptors in the frontal cortex in Alzheimer's disease.

31 March 2020

1 reference

Improved spatial recognition memory in mice lacking adenosine A2A receptors

31 March 2020

1 reference

Working memory deficits in transgenic rats overexpressing human adenosine A2A receptors in the brain.

31 March 2020

1 reference

Neuroprotection by caffeine and adenosine A2A receptor blockade of beta-amyloid neurotoxicity

31 March 2020

1 reference

Caffeine and adenosine A(2a) receptor antagonists prevent beta-amyloid (25-35)-induced cognitive deficits in mice.

31 March 2020

1 reference

Caffeine protects Alzheimer's mice against cognitive impairment and reduces brain beta-amyloid production

31 March 2020

1 reference

Adenosine A2A receptor blockade prevents synaptotoxicity and memory dysfunction caused by beta-amyloid peptides via p38 mitogen-activated protein kinase pathway

31 March 2020

1 reference

Caffeine stimulates amyloid beta-peptide release from beta-amyloid precursor protein-transfected HEK293 cells.

31 March 2020

1 reference

Chemokine expression by glial cells directs leukocytes to sites of axonal injury in the CNS.

31 March 2020

1 reference

Identification of monocyte chemoattractant protein-1 in senile plaques and reactive microglia of Alzheimer's disease.

31 March 2020

1 reference

Amyloid-beta-induced chemokine production in primary human macrophages and astrocytes

31 March 2020

1 reference

Ccr2 deficiency impairs microglial accumulation and accelerates progression of Alzheimer-like disease.

31 March 2020

1 reference

Fractalkine cleavage from neuronal membranes represents an acute event in the inflammatory response to excitotoxic brain damage

31 March 2020

1 reference

Role for neuronally derived fractalkine in mediating interactions between neurons and CX3CR1-expressing microglia

31 March 2020

1 reference

Microglial Cx3cr1 knockout prevents neuron loss in a mouse model of Alzheimer's disease

31 March 2020

1 reference

Formation and maintenance of Alzheimer's disease beta-amyloid plaques in the absence of microglia

31 March 2020

1 reference

Somatostatin and its receptor family

31 March 2020

1 reference

Expression of somatostatin receptor subtypes (SSTR1-5) in Alzheimer's disease brain: an immunohistochemical analysis.

31 March 2020

1 reference

Alzheimer's disease: low cerebral somatostatin levels correlate with impaired cognitive function and cortical metabolism

31 March 2020

1 reference

Differential correlation between neurochemical deficits, neuropathology, and cognitive status in Alzheimer's disease.

31 March 2020

1 reference

Reduced somatostatin-like immunoreactivity in cerebral cortex from cases of Alzheimer disease and Alzheimer senile dementa

31 March 2020

1 reference

Somatostatin regulates brain amyloid beta peptide Abeta42 through modulation of proteolytic degradation.

31 March 2020

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Metabolic regulation of brain Abeta by neprilysin.

31 March 2020

1 reference

Early neuropathology of somatostatin/NPY GABAergic cells in the hippocampus of a PS1xAPP transgenic model of Alzheimer's disease

31 March 2020

1 reference

Can Alzheimer disease be prevented by amyloid-beta immunotherapy?

31 March 2020

1 reference

The molecular pathology of Alzheimer's disease

31 March 2020

1 reference

Alzheimer's disease: the amyloid cascade hypothesis

31 March 2020

1 reference

The cholinergic hypothesis of geriatric memory dysfunction

31 March 2020

1 reference

Selective loss of central cholinergic neurons in Alzheimer's disease

31 March 2020

1 reference

Alzheimer's disease and senile dementia: loss of neurons in the basal forebrain

31 March 2020

1 reference

The critical role of cholinergic basal forebrain neurons in morphological change and memory encoding: a hypothesis

31 March 2020

1 reference

Dysregulated hippocampal acetylcholine neurotransmission and impaired cognition in M2, M4 and M2/M4 muscarinic receptor knockout mice

31 March 2020

1 reference

Characterization of central inhibitory muscarinic autoreceptors by the use of muscarinic acetylcholine receptor knock-out mice.

31 March 2020

1 reference

Activation of m1 muscarinic acetylcholine receptor regulates tau phosphorylation in transfected PC12 cells

31 March 2020

1 reference

Chronic nicotine administration exacerbates tau pathology in a transgenic model of Alzheimer's disease

31 March 2020

1 reference

Therapy Insight: type 2 diabetes mellitus and the risk of late-onset Alzheimer's disease

31 March 2020

1 reference

Place learning and hippocampal synaptic plasticity in streptozotocin-induced diabetic rats.

31 March 2020

1 reference

Brain insulin receptors and spatial memory. Correlated changes in gene expression, tyrosine phosphorylation, and signaling molecules in the hippocampus of water maze trained rats

31 March 2020

1 reference

Insulin and the insulin receptor in experimental models of learning and memory.

31 March 2020

1 reference

The role of insulin and insulin-like growth factor I in the molecular and cellular mechanisms underlying the pathology of Alzheimer's disease

31 March 2020

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Insulin in combination with other diabetes medication is associated with less Alzheimer neuropathology

31 March 2020

1 reference

Effects of insulinic therapy on cognitive impairment in patients with Alzheimer disease and diabetes mellitus type-2.

31 March 2020

1 reference

Common pathological processes in Alzheimer disease and type 2 diabetes: a review

31 March 2020

1 reference

Impairment of synaptic plasticity and memory formation in GLP-1 receptor KO mice: Interaction between type 2 diabetes and Alzheimer's disease.

31 March 2020

1 reference

Glucagon-like peptide-1 decreases endogenous amyloid-beta peptide (Abeta) levels and protects hippocampal neurons from death induced by Abeta and iron.

31 March 2020

1 reference

GLP-1 agonists facilitate hippocampal LTP and reverse the impairment of LTP induced by beta-amyloid

31 March 2020

1 reference

Val8-glucagon-like peptide-1 protects against Aβ1-40-induced impairment of hippocampal late-phase long-term potentiation and spatial learning in rats.

31 March 2020

1 reference

GLP-1 amplifies insulin signaling by up-regulation of IRbeta, IRS-1 and Glut4 in 3T3-L1 adipocytes

31 March 2020

1 reference

Glucagon-like peptide-1 promotes DNA synthesis, activates phosphatidylinositol 3-kinase and increases transcription factor pancreatic and duodenal homeobox gene 1 (PDX-1) DNA binding activity in beta (INS-1)-cells

31 March 2020

1 reference

Glucagon-like peptide-1 receptor is involved in learning and neuroprotection

31 March 2020

1 reference

Purification and characterization of a peptide from amyloid-rich pancreases of type 2 diabetic patients

31 March 2020

1 reference

Insulin-like growth factor I protects and rescues hippocampal neurons against beta-amyloid- and human amylin-induced toxicity.

31 March 2020

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Antagonist of the amylin receptor blocks beta-amyloid toxicity in rat cholinergic basal forebrain neurons.

31 March 2020

1 reference

Diabetes-accelerated memory dysfunction via cerebrovascular inflammation and Abeta deposition in an Alzheimer mouse model with diabetes

31 March 2020

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Reduction of cerebrospinal fluid amyloid beta after systemic administration of M1 muscarinic agonists

31 March 2020

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Glutamate-stimulated secretion of amyloid precursor protein from cortical rat brain slices

31 March 2020

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Metabotropic glutamate receptor subtype mGluR1alpha stimulates the secretion of the amyloid beta-protein precursor ectodomain.

31 March 2020

1 reference

Crosstalk between Rap1 and Rac regulates secretion of sAPPalpha

31 March 2020

1 reference

Distinct functional effects of human 5-HT4 receptor isoforms on beta-amyloid secretion

31 March 2020

1 reference

GROalpha/KC, a chemokine receptor CXCR2 ligand, can be a potent trigger for neuronal ERK1/2 and PI-3 kinase pathways and for tau hyperphosphorylation-a role in Alzheimer's disease?

31 March 2020

1 reference

Dominant negative AT2 receptor oligomers induce G-protein arrest and symptoms of neurodegeneration

31 March 2020

1 reference

Adenosine A2A receptor blockade prevents memory dysfunction caused by beta-amyloid peptides but not by scopolamine or MK-801.

31 March 2020

1 reference

Chronic nicotine treatment reduces beta-amyloidosis in the brain of a mouse model of Alzheimer's disease (APPsw).

31 March 2020

1 reference

Nicotine reduces A beta in the brain and cerebral vessels of APPsw mice.

31 March 2020

1 reference

Alpha 7 nicotinic acetylcholine receptors mediate beta-amyloid peptide-induced tau protein phosphorylation

31 March 2020

1 reference

Beta-amyloid activates the mitogen-activated protein kinase cascade via hippocampal alpha7 nicotinic acetylcholine receptors: In vitro and in vivo mechanisms related to Alzheimer's disease

31 March 2020

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Effect of subchronic treatment of memantine, galantamine, and nicotine in the brain of Tg2576 (APPswe) transgenic mice

31 March 2020

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beta-Amyloid(1-42) peptide directly modulates nicotinic receptors in the rat hippocampal slice.

31 March 2020

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Deletion of the alpha 7 nicotinic acetylcholine receptor gene improves cognitive deficits and synaptic pathology in a mouse model of Alzheimer's disease

31 March 2020

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Memantine treatment decreases levels of secreted Alzheimer's amyloid precursor protein (APP) and amyloid beta (A beta) peptide in the human neuroblastoma cells

31 March 2020

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Memantine lowers amyloid-beta peptide levels in neuronal cultures and in APP/PS1 transgenic mice.

31 March 2020

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Memantine improves spatial learning in a transgenic mouse model of Alzheimer's disease.

31 March 2020

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Memantine leads to behavioral improvement and amyloid reduction in Alzheimer's-disease-model transgenic mice shown as by micromagnetic resonance imaging

31 March 2020

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Involvement of formyl-peptide-receptor-like-1 and phospholipase D in the internalization and signal transduction of amyloid beta 1-42 in glial cells

31 March 2020

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Activation of protein kinase C inhibits cellular production of the amyloid beta-protein

31 March 2020

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12 December 2020

Functional expression of the rat glucagon-like peptide-I receptor, evidence for coupling to both adenylyl cyclase and phospholipase-C.

1 reference

12 December 2020

Increased activity-regulating and neuroprotective efficacy of alpha-secretase-derived secreted amyloid precursor protein conferred by a C-terminal heparin-binding domain

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12 December 2020

MPEP reduces seizure severity in Fmr-1 KO mice over expressing human Abeta

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12 December 2020

A1, but not A2A, adenosine receptors modulate electrically stimulated [14C]acetylcholine release from rat cortex.

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12 December 2020

AGTR2 mutations in X-linked mental retardation

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12 December 2020

Corticotropin-releasing hormone-mediated neuroprotection against oxidative stress is associated with the increased release of non-amyloidogenic amyloid beta precursor protein and with the suppression of nuclear factor-kappaB

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12 December 2020

Unveiling the functions of presynaptic metabotropic glutamate receptors in the central nervous system

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12 December 2020

The selective muscarinic M1 agonist AF102B decreases levels of total Abeta in cerebrospinal fluid of patients with Alzheimer's disease.

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12 December 2020

5-HT4 receptor stimulation facilitates acetylcholine release in rat frontal cortex.

1 reference

12 December 2020

Activation of a cAMP-regulated Ca(2+)-signaling pathway in pancreatic beta-cells by the insulinotropic hormone glucagon-like peptide-1

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12 December 2020

The neurobiology of somatostatin

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12 December 2020

Angiotensin II type 2 receptor-mediated apoptosis of cultured neurons from newborn rat brain.

1 reference

12 December 2020

Pancreatic glucagon-like peptide-1 receptor couples to multiple G proteins and activates mitogen-activated protein kinase pathways in Chinese hamster ovary cells

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12 December 2020

Microglial response to amyloid plaques in APPsw transgenic mice.

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12 December 2020

International Union of Pharmacology. XXV. Nomenclature and classification of adenosine receptors

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12 December 2020

Longitudinal brain corticotropin releasing factor and somatostatin in a transgenic mouse (TG2576) model of Alzheimer's disease

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12 December 2020

Expression of chemokine receptors by subsets of neurons in the central nervous system

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12 December 2020

Interleukin-8 receptor B immunoreactivity in brain and neuritic plaques of Alzheimer's disease

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12 December 2020

Caffeine enhances acetylcholine release in the hippocampus in vivo by a selective interaction with adenosine A1 receptors

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12 December 2020

A1 adenosine receptors accumulate in neurodegenerative structures in Alzheimer disease and mediate both amyloid precursor protein processing and tau phosphorylation and translocation

1 reference

12 December 2020

Production of antisera selective for m1 muscarinic receptors using fusion proteins: distribution of m1 receptors in rat brain.

1 reference

12 December 2020

Identifiers

DOI

10.1038/NRN2977

1 reference

24 August 2017

1 reference

PubMed ID

21248787