(Q53364131)

13 May 2018

title

Ablation of very long acyl chain sphingolipids causes hepatic insulin resistance in mice due to altered detergent-resistant membranes. (English)

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13 May 2018

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6

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author name string

Joo-Won Park

1

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13 May 2018

Woo-Jae Park

2

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13 May 2018

Yael Kuperman

3

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13 May 2018

Sigalit Boura-Halfon

4

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13 May 2018

Yael Pewzner-Jung

5

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13 May 2018

language of work or name

English

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publication date

6 December 2012

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13 May 2018

published in

Hepatology

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13 May 2018

volume

57

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13 May 2018

issue

2

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13 May 2018

page(s)

525-532

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13 May 2018

A role for sphingolipids in producing the common features of type 2 diabetes, metabolic syndrome X, and Cushing's syndrome

cites work

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Characterization of ceramide synthase 2: tissue distribution, substrate specificity, and inhibition by sphingosine 1-phosphate

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Mammalian Lass6 and its related family members regulate synthesis of specific ceramides

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Antiapoptotic roles of ceramide-synthase-6-generated C16-ceramide via selective regulation of the ATF6/CHOP arm of ER-stress-response pathways

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Ceramide synthases 2, 5, and 6 confer distinct roles in radiation-induced apoptosis in HeLa cells

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Dissociation of the insulin receptor and caveolin-1 complex by ganglioside GM3 in the state of insulin resistance

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A critical role for ceramide synthase 2 in liver homeostasis: II. insights into molecular changes leading to hepatopathy

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Lipid rafts and signal transduction

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Dynamic association of human insulin receptor with lipid rafts in cells lacking caveolae

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Flotillin and epidermal surface antigen define a new family of caveolae-associated integral membrane proteins

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Defective insulin receptor activation and altered lipid rafts in Niemann-Pick type C disease hepatocytes

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Ceramide content is increased in skeletal muscle from obese insulin-resistant humans

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Lipotoxicity in type 2 diabetic cardiomyopathy

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Inhibition of ceramide synthesis ameliorates glucocorticoid-, saturated-fat-, and obesity-induced insulin resistance

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Inhibition of de novo ceramide synthesis reverses diet-induced insulin resistance and enhances whole-body oxygen consumption

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Insulin resistance: a metabolic pathway to chronic liver disease

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Mechanism of hepatic insulin resistance in non-alcoholic fatty liver disease.

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Impact of liver diseases on the development of type 2 diabetes mellitus

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Mechanisms of ceramide-mediated repression of the human telomerase reverse transcriptase promoter via deacetylation of Sp3 by histone deacetylase 1

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Membrane organization and lipid rafts

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Significance of glycosphingolipid fatty acid chain length on membrane microdomain-mediated signal transduction

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Anthrax toxin triggers endocytosis of its receptor via a lipid raft-mediated clathrin-dependent process

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Modulation of lipid rafts by Omega-3 fatty acids in inflammation and cancer: implications for use of lipids during nutrition support

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Ablation of ceramide synthase 2 strongly affects biophysical properties of membranes

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Respiratory chain defects may present only with hypoglycemia

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Nrf2-regulated PPAR{gamma} expression is critical to protection against acute lung injury in mice

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Hepatic overexpression of SIRT1 in mice attenuates endoplasmic reticulum stress and insulin resistance in the liver

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Plasma resistin, adiponectin and leptin levels in lean and obese subjects: correlations with insulin resistance

21 January 2018

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Adiponectin-leptin ratio: a useful estimate of insulin resistance in patients with Type 2 diabetes

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Sphingomyelinase and ceramide suppress insulin-induced tyrosine phosphorylation of the insulin receptor substrate-1

21 January 2018

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7 January 2021

Ceramide synthase inhibition by fumonisin B1 treatment activates sphingolipid-metabolizing systems in mouse liver

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7 January 2021

Lipid rafts and insulin signaling

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7 January 2021

Involvement of very long fatty acid-containing lactosylceramide in lactosylceramide-mediated superoxide generation and migration in neutrophils

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7 January 2021

Loss of insulin signaling in hepatocytes leads to severe insulin resistance and progressive hepatic dysfunction

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7 January 2021

Sirtuins as regulators of metabolism and healthspan

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7 January 2021

Identifiers

DOI

10.1002/HEP.26015

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13 May 2018

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13 May 2018