(Q53398002)

13 May 2018

title

Synaptic Tau Seeding Precedes Tau Pathology in Human Alzheimer's Disease Brain. (English)

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13 May 2018

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11

Bradley T Hyman

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13 May 2018

10

Matthew P Frosch

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13 May 2018

author name string

Sarah L DeVos

1

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13 May 2018

Bianca T Corjuc

2

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13 May 2018

Derek H Oakley

3

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13 May 2018

Chloe K Nobuhara

4

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13 May 2018

Riley N Bannon

5

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13 May 2018

Alison Chase

6

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13 May 2018

Caitlin Commins

7

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13 May 2018

Jose A Gonzalez

8

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13 May 2018

Patrick M Dooley

9

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13 May 2018

publication date

24 April 2018

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13 May 2018

Frontiers in Neuroscience

published in

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13 May 2018

volume

12

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13 May 2018

page(s)

267

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13 May 2018

Creative Commons Attribution 4.0 International

copyright license

start time

24 April 2018

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

0 references

describes a project that uses

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC5928393/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

cites work

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Proteopathic tau seeding predicts tauopathy in vivo.

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22 May 2018

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Soluble pathological tau in the entorhinal cortex leads to presynaptic deficits in an early Alzheimer's disease model

22 May 2018

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Anti-tau antibodies that block tau aggregate seeding in vitro markedly decrease pathology and improve cognition in vivo.

22 May 2018

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22 May 2018

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22 May 2018

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Beta-amyloid, phospho-tau and alpha-synuclein deposits similar to those in the brain are not identified in the eyes of Alzheimer's and Parkinson's disease patients

22 May 2018

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Brain homogenates from human tauopathies induce tau inclusions in mouse brain

22 May 2018

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Synthetic tau fibrils mediate transmission of neurofibrillary tangles in a transgenic mouse model of Alzheimer's-like tauopathy

22 May 2018

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Small misfolded Tau species are internalized via bulk endocytosis and anterogradely and retrogradely transported in neurons

22 May 2018

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22 May 2018

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22 May 2018

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22 May 2018

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22 May 2018

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22 May 2018

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22 May 2018

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22 May 2018

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Tau-targeted immunization impedes progression of neurofibrillary histopathology in aged P301L tau transgenic mice

22 May 2018

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22 May 2018

1 reference

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Propagation of tau misfolding from the outside to the inside of a cell.

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5928393

Synapse loss and microglial activation precede tangles in a P301S tauopathy mouse model

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5928393

Imaging brain amyloid in Alzheimer's disease with Pittsburgh Compound-B

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5928393

Determination of regional cerebral function with FDG-PET imaging in neuropsychiatric disorders

22 May 2018

1 reference

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Alzheimer's disease: cell-specific pathology isolates the hippocampal formation

22 May 2018

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22 May 2018

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Neuropathological stageing of Alzheimer-related changes

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5928393

Neurofibrillary tangles but not senile plaques parallel duration and severity of Alzheimer's disease

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5928393

Networks of tau distribution in Alzheimer's disease

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5928393

Local and distant relationships between amyloid, tau and neurodegeneration in Alzheimer's Disease

13 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5928393

Pathological Tau Strains from Human Brains Recapitulate the Diversity of Tauopathies in Nontransgenic Mouse Brain

13 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5928393

Tau Antibody Targeting Pathological Species Blocks Neuronal Uptake and Interneuron Propagation of Tau in Vitro

13 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5928393

Association of In Vivo [18F]AV-1451 Tau PET Imaging Results With Cortical Atrophy and Symptoms in Typical and Atypical Alzheimer Disease.

13 August 2018

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Widespread tau seeding activity at early Braak stages.

13 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5928393

Synaptic Contacts Enhance Cell-to-Cell Tau Pathology Propagation.

13 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5928393

Tau-targeting passive immunization modulates aspects of pathology in tau transgenic mice.

13 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5928393

Passive immunization with Tau oligomer monoclonal antibody reverses tauopathy phenotypes without affecting hyperphosphorylated neurofibrillary tangles.

13 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5928393

Differential distribution of neurons in the gyral white matter of the human cerebral cortex

13 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5928393

Efficacy and safety of immunization with phosphorylated tau against neurofibrillary tangles in mice.

13 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5928393

Synaptic alterations in CA1 in mild Alzheimer disease and mild cognitive impairment.

13 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5928393

Phases of A beta-deposition in the human brain and its relevance for the development of AD.

13 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5928393

Retinal ganglion cell degeneration in Alzheimer's disease

13 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5928393

13 August 2018

Identifiers

DOI

10.3389/FNINS.2018.00267

1 reference

13 May 2018

PMCID

5928393

1 reference

13 May 2018

PubMed ID

29740275

1 reference

13 May 2018