(Q50856591)

English

Passive immunization with Tau oligomer monoclonal antibody reverses tauopathy phenotypes without affecting hyperphosphorylated neurofibrillary tangles.

scientific article published in March 2014

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scholarly article

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24647946%20AND%20SRC:MED&resulttype=core&format=json

11 March 2020

Passive immunization with Tau oligomer monoclonal antibody reverses tauopathy phenotypes without affecting hyperphosphorylated neurofibrillary tangles (English)

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24647946%20AND%20SRC:MED&resulttype=core&format=json

11 March 2020

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passive immunization

1 reference

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monoclonal antibody

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Diana L Castillo-Carranza

1

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24647946%20AND%20SRC:MED&resulttype=core&format=json

11 March 2020

author name string

Urmi Sengupta

2

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11 March 2020

Marcos J Guerrero-Muñoz

3

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11 March 2020

Cristian A Lasagna-Reeves

4

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11 March 2020

Julia E Gerson

5

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11 March 2020

Gurpreet Singh

6

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11 March 2020

D Mark Estes

7

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11 March 2020

Kelly T Dineley

9

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11 March 2020

George R Jackson

10

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11 March 2020

Rakez Kayed

11

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11 March 2020

Alan D T Barrett

8

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11 March 2020

language of work or name

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publication date

1 March 2014

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11 March 2020

number of pages

13

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Journal of Neuroscience

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Europe PubMed Central

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11 March 2020

34

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11 March 2020

12

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11 March 2020

4260-4272

1 reference

Europe PubMed Central

PMC publication ID

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11 March 2020

describes a project that uses

1 reference

Europe PubMed Central

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC6608097/fullTextXML

based on heuristic

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Neurons may live for decades with neurofibrillary tangles

1 reference

https://pubmed.ncbi.nlm.nih.gov/24647946

12 December 2020

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Behavioral changes in transgenic mice expressing both amyloid precursor protein and presenilin-1 mutations: lack of association with amyloid deposits.

1 reference

https://pubmed.ncbi.nlm.nih.gov/24647946

12 December 2020

based on heuristic

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Neurofibrillary tangles, amyotrophy and progressive motor disturbance in mice expressing mutant (P301L) tau protein

1 reference

https://pubmed.ncbi.nlm.nih.gov/24647946

12 December 2020

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Peripherally administered antibodies against amyloid beta-peptide enter the central nervous system and reduce pathology in a mouse model of Alzheimer disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/24647946

12 December 2020

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Do neuronal inclusions kill the cell?

1 reference

https://pubmed.ncbi.nlm.nih.gov/24647946

12 December 2020

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Tauopathy in Drosophila: neurodegeneration without neurofibrillary tangles

1 reference

https://pubmed.ncbi.nlm.nih.gov/24647946

12 December 2020

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Peripheral anti-A beta antibody alters CNS and plasma A beta clearance and decreases brain A beta burden in a mouse model of Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/24647946

12 December 2020

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Specific tau phosphorylation sites correlate with severity of neuronal cytopathology in Alzheimer's disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/24647946

12 December 2020

based on heuristic

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Tau is essential to beta -amyloid-induced neurotoxicity

1 reference

https://pubmed.ncbi.nlm.nih.gov/24647946

12 December 2020

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Intracranially Administered Anti-Αβ Antibodies Reduce β-Amyloid Deposition by Mechanisms Both Independent of and Associated with Microglial Activation

1 reference

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12 December 2020

based on heuristic

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Intracerebroventricular passive immunization with anti-Abeta antibody in Tg2576.

1 reference

https://pubmed.ncbi.nlm.nih.gov/24647946

12 December 2020

based on heuristic

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Evidence for peripheral clearance of cerebral Abeta protein following chronic, active Abeta immunization in PSAPP mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/24647946

12 December 2020

based on heuristic

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Passive amyloid immunotherapy clears amyloid and transiently activates microglia in a transgenic mouse model of amyloid deposition.

1 reference

https://pubmed.ncbi.nlm.nih.gov/24647946

12 December 2020

based on heuristic

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Template-assisted filament growth by parallel stacking of tau.

1 reference

https://pubmed.ncbi.nlm.nih.gov/24647946

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Abeta immunotherapy leads to clearance of early, but not late, hyperphosphorylated tau aggregates via the proteasome

1 reference

https://pubmed.ncbi.nlm.nih.gov/24647946

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of alpha-synuclein immunization in a mouse model of Parkinson's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/24647946

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Tau suppression in a neurodegenerative mouse model improves memory function

1 reference

https://pubmed.ncbi.nlm.nih.gov/24647946

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Tau protein abnormalities associated with the progression of alzheimer disease type dementia

1 reference

https://pubmed.ncbi.nlm.nih.gov/24647946

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Increased levels of granular tau oligomers: an early sign of brain aging and Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/24647946

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Tauopathy-like abnormalities and neurologic deficits in mice immunized with neuronal tau protein

1 reference

https://pubmed.ncbi.nlm.nih.gov/24647946

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Insights into the mechanisms of action of anti-Abeta antibodies in Alzheimer's disease mouse models

1 reference

https://pubmed.ncbi.nlm.nih.gov/24647946

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Intracerebroventricular passive immunization with anti-oligoAbeta antibody in TgCRND8.

1 reference

https://pubmed.ncbi.nlm.nih.gov/24647946

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Synapse loss and microglial activation precede tangles in a P301S tauopathy mouse model

1 reference

https://pubmed.ncbi.nlm.nih.gov/24647946

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Accumulation of pathological tau species and memory loss in a conditional model of tauopathy.

1 reference

https://pubmed.ncbi.nlm.nih.gov/24647946

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Reducing endogenous tau ameliorates amyloid beta-induced deficits in an Alzheimer's disease mouse model

1 reference

https://pubmed.ncbi.nlm.nih.gov/24647946

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Blood-brain barrier impairment in Alzheimer disease: stability and functional significance

1 reference

https://pubmed.ncbi.nlm.nih.gov/24647946

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Tau-mediated neurodegeneration in Alzheimer's disease and related disorders

1 reference

https://pubmed.ncbi.nlm.nih.gov/24647946

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Immunotherapy targeting pathological tau conformers in a tangle mouse model reduces brain pathology with associated functional improvements.

1 reference

https://pubmed.ncbi.nlm.nih.gov/24647946

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Non-tau based neuronal degeneration in Alzheimer's disease -- an immunocytochemical and quantitative study in the supragranular layers of the middle temporal neocortex.

1 reference

https://pubmed.ncbi.nlm.nih.gov/24647946

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Tau-based treatment strategies in neurodegenerative diseases

1 reference

https://pubmed.ncbi.nlm.nih.gov/24647946

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Immunotherapy targeting pathological tau protein in Alzheimer's disease and related tauopathies.

1 reference

https://pubmed.ncbi.nlm.nih.gov/24647946

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Physicochemical mechanisms of histological silver staining and their utilization for rendering individual silver methods selective and reliable

1 reference

https://pubmed.ncbi.nlm.nih.gov/24647946

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Apparent behavioral benefits of tau overexpression in P301L tau transgenic mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/24647946

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Intracerebroventricular amyloid-beta antibodies reduce cerebral amyloid angiopathy and associated micro-hemorrhages in aged Tg2576 mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/24647946

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Quantitative and mechanistic studies of Abeta immunotherapy

1 reference

https://pubmed.ncbi.nlm.nih.gov/24647946

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Age-dependent impairment of cognitive and synaptic function in the htau mouse model of tau pathology

1 reference

https://pubmed.ncbi.nlm.nih.gov/24647946

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Abeta immunotherapy: intracerebral sequestration of Abeta by an anti-Abeta monoclonal antibody 266 with high affinity to soluble Abeta

1 reference

https://pubmed.ncbi.nlm.nih.gov/24647946

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Prion-like mechanisms in neurodegenerative diseases

1 reference

https://pubmed.ncbi.nlm.nih.gov/24647946

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Rapid cerebral amyloid binding by Aβ antibodies infused into β-amyloid precursor protein transgenic mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/24647946

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Efficacy and safety of immunization with phosphorylated tau against neurofibrillary tangles in mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/24647946

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Recent advances in the development of immunotherapies for tauopathies

1 reference

https://pubmed.ncbi.nlm.nih.gov/24647946

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Preparation and characterization of neurotoxic tau oligomers

1 reference

https://pubmed.ncbi.nlm.nih.gov/24647946

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Immunotherapy for Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/24647946

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Amyloid-β annular protofibrils evade fibrillar fate in Alzheimer disease brain

1 reference

https://pubmed.ncbi.nlm.nih.gov/24647946

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inflammation induced by infection potentiates tau pathological features in transgenic mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/24647946

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Characterization of prefibrillar Tau oligomers in vitro and in Alzheimer disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/24647946

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Passive immunization reduces behavioral and neuropathological deficits in an alpha-synuclein transgenic model of Lewy body disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/24647946

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Tau oligomers as potential targets for immunotherapy for Alzheimer's disease and tauopathies.

1 reference

https://pubmed.ncbi.nlm.nih.gov/24647946

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Are tangles as toxic as they look?

1 reference

https://pubmed.ncbi.nlm.nih.gov/24647946

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Passive immunization targeting pathological phospho-tau protein in a mouse model reduces functional decline and clears tau aggregates from the brain

1 reference

https://pubmed.ncbi.nlm.nih.gov/24647946

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Tau oligomers impair memory and induce synaptic and mitochondrial dysfunction in wild-type mice.

1 reference

https://pubmed.ncbi.nlm.nih.gov/24647946

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Soluble tau species, not neurofibrillary aggregates, disrupt neural system integration in a tau transgenic model

1 reference

https://pubmed.ncbi.nlm.nih.gov/24647946

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Immunotherapy for tauopathies.

1 reference

https://pubmed.ncbi.nlm.nih.gov/24647946

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Passive immunization with anti-Tau antibodies in two transgenic models: reduction of Tau pathology and delay of disease progression.

1 reference

https://pubmed.ncbi.nlm.nih.gov/24647946

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mechanistic Studies of Antibody-Mediated Clearance of Tau Aggregates Using an ex vivo Brain Slice Model

1 reference

https://pubmed.ncbi.nlm.nih.gov/24647946

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Tau-targeted immunization impedes progression of neurofibrillary histopathology in aged P301L tau transgenic mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/24647946

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identification of oligomers at early stages of tau aggregation in Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/24647946

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Targeting phospho-Ser422 by active Tau Immunotherapy in the THYTau22 mouse model: a suitable therapeutic approach

1 reference

https://pubmed.ncbi.nlm.nih.gov/24647946

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Trans-cellular propagation of Tau aggregation by fibrillar species

1 reference

https://pubmed.ncbi.nlm.nih.gov/24647946

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Extensive p-tau pathology and SDS-stable p-tau oligomers in Alzheimer's cortical synapses

1 reference

https://pubmed.ncbi.nlm.nih.gov/24647946

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

What is the pathological significance of tau oligomers?

1 reference

https://pubmed.ncbi.nlm.nih.gov/24647946

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The synaptic accumulation of hyperphosphorylated tau oligomers in Alzheimer disease is associated with dysfunction of the ubiquitin-proteasome system

1 reference

https://pubmed.ncbi.nlm.nih.gov/24647946

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Antibody-aided clearance of extracellular α-synuclein prevents cell-to-cell aggregate transmission

1 reference

https://pubmed.ncbi.nlm.nih.gov/24647946

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Alzheimer brain-derived tau oligomers propagate pathology from endogenous tau

1 reference

https://pubmed.ncbi.nlm.nih.gov/24647946

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Small misfolded Tau species are internalized via bulk endocytosis and anterogradely and retrogradely transported in neurons

1 reference

https://pubmed.ncbi.nlm.nih.gov/24647946

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Curcumin suppresses soluble tau dimers and corrects molecular chaperone, synaptic, and behavioral deficits in aged human tau transgenic mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/24647946

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Tau aggregates as immunotherapeutic targets

1 reference

https://pubmed.ncbi.nlm.nih.gov/24647946

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Rapid accumulation of endogenous tau oligomers in a rat model of traumatic brain injury: possible link between traumatic brain injury and sporadic tauopathies

1 reference

https://pubmed.ncbi.nlm.nih.gov/24647946

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Tau passive immunotherapy in mutant P301L mice: antibody affinity versus specificity

1 reference

https://pubmed.ncbi.nlm.nih.gov/24647946

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Formation and propagation of tau oligomeric seeds

1 reference

https://pubmed.ncbi.nlm.nih.gov/24647946

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Accelerated neurodegeneration through chaperone-mediated oligomerization of tau.

1 reference

https://pubmed.ncbi.nlm.nih.gov/24647946

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Anti-tau antibodies that block tau aggregate seeding in vitro markedly decrease pathology and improve cognition in vivo.

1 reference

https://pubmed.ncbi.nlm.nih.gov/24647946

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Tau oligomers as potential targets for Alzheimer's diagnosis and novel drugs

1 reference

https://pubmed.ncbi.nlm.nih.gov/24647946

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Immunotherapy for the treatment of Alzheimer's disease: amyloid-β or tau, which is the right target?

1 reference

https://pubmed.ncbi.nlm.nih.gov/24647946

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neuronal loss correlates with but exceeds neurofibrillary tangles in Alzheimer's disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/24647946

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1523/JNEUROSCI.3192-13.2014

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24647946%20AND%20SRC:MED&resulttype=core&format=json

11 March 2020

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24647946%20AND%20SRC:MED&resulttype=core&format=json

11 March 2020

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24647946%20AND%20SRC:MED&resulttype=core&format=json

11 March 2020

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