(Q36005623)

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Passive immunization targeting pathological phospho-tau protein in a mouse model reduces functional decline and clears tau aggregates from the brain

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scholarly article

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Europe PubMed Central

PMC publication ID

11 August 2017

Passive immunization targeting pathological phospho-tau protein in a mouse model reduces functional decline and clears tau aggregates from the brain (English)

1 reference

Europe PubMed Central

PMC publication ID

11 August 2017

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passive immunization

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based on heuristic

inferred from title

object named as

Peter Davies

3

0 references

Einar M Sigurdsson

object named as

Einar M Sigurdsson

4

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author name string

Allal Boutajangout

1

1 reference

Europe PubMed Central

PMC publication ID

11 August 2017

Johanna Ingadottir

2

1 reference

Europe PubMed Central

PMC publication ID

11 August 2017

language of work or name

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publication date

1 July 2011

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Europe PubMed Central

PMC publication ID

11 August 2017

number of pages

10

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Journal of Neurochemistry

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Europe PubMed Central

PMC publication ID

11 August 2017

118

1 reference

Europe PubMed Central

PMC publication ID

11 August 2017

4

1 reference

Europe PubMed Central

PMC publication ID

11 August 2017

658-667

1 reference

Europe PubMed Central

PMC publication ID

11 August 2017

describes a project that uses

1 reference

Europe PubMed Central

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC3366469/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

Mechanistic Studies of Antibody-Mediated Clearance of Tau Aggregates Using an ex vivo Brain Slice Model

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3366469

2 October 2017

Immunotherapy targeting pathological tau prevents cognitive decline in a new tangle mouse model

1 reference

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2 October 2017

Clinical pharmacokinetics of therapeutic monoclonal antibodies

1 reference

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2 October 2017

Systemic inflammatory cells fight off neurodegenerative disease

1 reference

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2 October 2017

T cells specifically targeted to amyloid plaques enhance plaque clearance in a mouse model of Alzheimer's disease

1 reference

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2 October 2017

Tau-focused immunotherapy for Alzheimer's disease and related tauopathies.

1 reference

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2 October 2017

Tau fragmentation, aggregation and clearance: the dual role of lysosomal processing

1 reference

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2 October 2017

Transmission and spreading of tauopathy in transgenic mouse brain

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3366469

2 October 2017

Propagation of tau misfolding from the outside to the inside of a cell.

1 reference

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2 October 2017

Long-term effects of Abeta42 immunisation in Alzheimer's disease: follow-up of a randomised, placebo-controlled phase I trial

1 reference

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2 October 2017

Autophagic-lysosomal perturbation enhances tau aggregation in transfectants with induced wild-type tau expression

1 reference

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2 October 2017

Autophagy, amyloidogenesis and Alzheimer disease

1 reference

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2 October 2017

Immunotherapy targeting pathological tau conformers in a tangle mouse model reduces brain pathology with associated functional improvements.

1 reference

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2 October 2017

Internalized antibodies to the Abeta domain of APP reduce neuronal Abeta and protect against synaptic alterations.

1 reference

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2 October 2017

Vaccination of Alzheimer's model mice with Abeta derivative in alum adjuvant reduces Abeta burden without microhemorrhages

1 reference

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2 October 2017

Immunotherapy for conformational diseases.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3366469

2 October 2017

Clinical effects of Abeta immunization (AN1792) in patients with AD in an interrupted trial.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3366469

2 October 2017

An attenuated immune response is sufficient to enhance cognition in an Alzheimer's disease mouse model immunized with amyloid-beta derivatives.

1 reference

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2 October 2017

Subacute meningoencephalitis in a subset of patients with AD after Abeta42 immunization

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3366469

2 October 2017

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1 reference

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2 October 2017

Reversible memory loss in a mouse transgenic model of Alzheimer's disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3366469

2 October 2017

Immunization with a nontoxic/nonfibrillar amyloid-beta homologous peptide reduces Alzheimer's disease-associated pathology in transgenic mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3366469

2 October 2017

Peripheral anti-A beta antibody alters CNS and plasma A beta clearance and decreases brain A beta burden in a mouse model of Alzheimer's disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3366469

2 October 2017

A beta peptide immunization reduces behavioural impairment and plaques in a model of Alzheimer's disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3366469

2 October 2017

Immunization with amyloid-beta attenuates Alzheimer-disease-like pathology in the PDAPP mouse

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3366469

2 October 2017

Disaggregation of Alzheimer beta-amyloid by site-directed mAb.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3366469

2 October 2017

A preparation of Alzheimer paired helical filaments that displays distinct tau proteins by polyacrylamide gel electrophoresis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3366469

2 October 2017

Lysosomal activation is a compensatory response against protein accumulation and associated synaptopathogenesis--an approach for slowing Alzheimer disease?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3366469

11 July 2018

Peripherally administered antibodies against amyloid beta-peptide enter the central nervous system and reduce pathology in a mouse model of Alzheimer disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3366469

11 July 2018

Neurofibrillary tangles, amyotrophy and progressive motor disturbance in mice expressing mutant (P301L) tau protein

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3366469

11 July 2018

Local and distant histopathological effects of unilateral amyloid-beta 25-35 injections into the amygdala of young F344 rats

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3366469

11 July 2018

Accumulation of circulating endogenous and exogenous immunoglobulins by hypothalamic magnocellular neurons

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3366469

11 July 2018

Tau in Alzheimer neurofibrillary tangles. N- and C-terminal regions are differentially associated with paired helical filaments and the location of a putative abnormal phosphorylation site

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3366469

11 July 2018

Efficacy and safety of immunization with phosphorylated tau against neurofibrillary tangles in mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3366469

23 September 2018

Abeta species removal after abeta42 immunization

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3366469

23 September 2018

Rapamycin alleviates toxicity of different aggregate-prone proteins

1 reference

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23 September 2018

Effects of alpha-synuclein immunization in a mouse model of Parkinson's disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3366469

23 September 2018

Abeta vaccination effects on plaque pathology in the absence of encephalitis in Alzheimer disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3366469

23 September 2018

Ultrastructural neuronal pathology in transgenic mice expressing mutant (P301L) human tau.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3366469

23 September 2018

Neuropathology and pathogenesis of encephalitis following amyloid-beta immunization in Alzheimer's disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3366469

23 September 2018

Characterisation of cytoskeletal abnormalities in mice transgenic for wild-type human tau and familial Alzheimer's disease mutants of APP and presenilin-1.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3366469

23 September 2018

Evidence for peripheral clearance of cerebral Abeta protein following chronic, active Abeta immunization in PSAPP mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3366469

23 September 2018

Antibodies against beta-amyloid slow cognitive decline in Alzheimer's disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3366469

23 September 2018

Neuropathology of human Alzheimer disease after immunization with amyloid-beta peptide: a case report.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3366469

23 September 2018

Non-Fc-mediated mechanisms are involved in clearance of amyloid-beta in vivo by immunotherapy.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3366469

23 September 2018

Increased tau phosphorylation but absence of formation of neurofibrillary tangles in mice double transgenic for human tau and Alzheimer mutant (M146L) presenilin-1.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3366469

23 September 2018

A beta peptide vaccination prevents memory loss in an animal model of Alzheimer's disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3366469

23 September 2018

Behavioral disturbances in transgenic mice overexpressing the V717F beta-amyloid precursor protein.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3366469

23 September 2018

Alz-50/Gallyas-positive lysosome-like intraneuronal granules in Alzheimer's disease and control brains

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3366469

23 September 2018

Monoclonal antibody PHF-1 recognizes tau protein phosphorylated at serine residues 396 and 404.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3366469

23 September 2018

FTDP-17 mutations in tau transgenic mice provoke lysosomal abnormalities and Tau filaments in forebrain

1 reference

https://pubmed.ncbi.nlm.nih.gov/21644996

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hydrofluoric acid-treated tau PHF proteins display the same biochemical properties as normal tau

1 reference

https://pubmed.ncbi.nlm.nih.gov/21644996

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Amyloid-beta immunization effectively reduces amyloid deposition in FcRgamma-/- knock-out mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/21644996

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Infectivity of amyloid diseases

1 reference

https://pubmed.ncbi.nlm.nih.gov/21644996

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1111/J.1471-4159.2011.07337.X

1 reference

Europe PubMed Central

PMC publication ID

11 August 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

11 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

11 August 2017

ResearchGate publication ID

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