(Q53644931)

16 May 2018

title

Genome-wide surveys for phosphorylation-dependent substrates of SCF ubiquitin ligases. (English)

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16 May 2018

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Xiaojing Tang

1

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16 May 2018

Stephen Orlicky

2

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16 May 2018

Qingquan Liu

3

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16 May 2018

Andrew Willems

4

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16 May 2018

Frank Sicheri

5

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16 May 2018

Mike Tyers

6

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16 May 2018

language of work or name

English

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publication date

1 January 2005

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16 May 2018

published in

Methods in Enzymology

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16 May 2018

volume

399

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16 May 2018

page(s)

433-458

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16 May 2018

SKP1 connects cell cycle regulators to the ubiquitin proteolysis machinery through a novel motif, the F-box

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Mutations of the CK2 phosphorylation site of Sic1 affect cell size and S-Cdk kinase activity in Saccharomyces cerevisiae.

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A complex of Cdc4p, Skp1p, and Cdc53p/cullin catalyzes ubiquitination of the phosphorylated CDK inhibitor Sic1p

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Mastermind recruits CycC:CDK8 to phosphorylate the Notch ICD and coordinate activation with turnover

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The cell-cycle regulatory protein Cks1 is required for SCF(Skp2)-mediated ubiquitinylation of p27

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The F-box protein beta-TrCP associates with phosphorylated beta-catenin and regulates its activity in the cell.

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7 January 2021

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7 January 2021

Mathematical modeling suggests cooperative interactions between a disordered polyvalent ligand and a single receptor site

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7 January 2021

Phosphorylation-dependent ubiquitination of cyclin E by the SCFFbw7 ubiquitin ligase

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Dual regulation of the met4 transcription factor by ubiquitin-dependent degradation and inhibition of promoter recruitment

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betaTrCP-mediated proteolysis of NF-kappaB1 p105 requires phosphorylation of p105 serines 927 and 932.

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7 January 2021

ATF4 degradation relies on a phosphorylation-dependent interaction with the SCF(betaTrCP) ubiquitin ligase

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A novel human WD protein, h-beta TrCp, that interacts with HIV-1 Vpu connects CD4 to the ER degradation pathway through an F-box motif

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7 January 2021

Prophase destruction of Emi1 by the SCF(betaTrCP/Slimb) ubiquitin ligase activates the anaphase promoting complex to allow progression beyond prometaphase

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7 January 2021

Degradation of the transcription factor Gcn4 requires the kinase Pho85 and the SCF(CDC4) ubiquitin-ligase complex

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7 January 2021

Multisite phosphorylation of a CDK inhibitor sets a threshold for the onset of DNA replication

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7 January 2021

The ubiquitin ligase SCFFbw7 antagonizes apoptotic JNK signaling

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7 January 2021

A novel proline-rich motif present in ActA of Listeria monocytogenes and cytoskeletal proteins is the ligand for the EVH1 domain, a protein module present in the Ena/VASP family

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7 January 2021

Phosphorylation of sic1, a cyclin-dependent kinase (Cdk) inhibitor, by Cdk including Pho85 kinase is required for its prompt degradation

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7 January 2021

Structural basis for phosphodependent substrate selection and orientation by the SCFCdc4 ubiquitin ligase

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7 January 2021

Cdc53 is a scaffold protein for multiple Cdc34/Skp1/F-box proteincomplexes that regulate cell division and methionine biosynthesis in yeast

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7 January 2021

Combinatorial control in ubiquitin-dependent proteolysis: don't Skp the F-box hypothesis

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7 January 2021

Protein modules and signalling networks

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7 January 2021

A proteomics approach to understanding protein ubiquitination

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7 January 2021

Separate SCF(CDC4) recognition elements target Cdc6 for proteolysis in S phase and mitosis.

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7 January 2021

Mechanisms underlying ubiquitination

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7 January 2021

Yeast G1 cyclins are unstable in G1 phase.

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7 January 2021

Cdc53/cullin and the essential Hrt1 RING-H2 subunit of SCF define a ubiquitin ligase module that activates the E2 enzyme Cdc34

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7 January 2021

F-box proteins are receptors that recruit phosphorylated substrates to the SCF ubiquitin-ligase complex

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7 January 2021

Reconstitution of G1 cyclin ubiquitination with complexes containing SCFGrr1 and Rbx1.

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7 January 2021

A phylogenetically conserved NAD+-dependent protein deacetylase activity in the Sir2 protein family.

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7 January 2021

SH2 domain specificity determination using oriented phosphopeptide library

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7 January 2021

Regulation and recognition of SCFGrr1 targets in the glucose and amino acid signaling pathways

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7 January 2021

A CDK-independent function of mammalian Cks1: targeting of SCF(Skp2) to the CDK inhibitor p27Kip1.

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7 January 2021

Human F-box protein hCdc4 targets cyclin E for proteolysis and is mutated in a breast cancer cell line

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7 January 2021

Systematic genetic analysis with ordered arrays of yeast deletion mutants

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7 January 2021

p27(Kip1) ubiquitination and degradation is regulated by the SCF(Skp2) complex through phosphorylated Thr187 in p27

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https://api.crossref.org/works/10.1016%2FS0076-6879%2805%2999030-7

7 January 2021

Targets of the cyclin-dependent kinase Cdk1

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7 January 2021

A comprehensive analysis of protein-protein interactions in Saccharomyces cerevisiae

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2805%2999030-7

7 January 2021

Naming a targeting signal

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2805%2999030-7

7 January 2021

Phosphorylation of Sic1p by G1 Cdk required for its degradation and entry into S phase

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2805%2999030-7

7 January 2021

Smad4 protein stability is regulated by ubiquitin ligase SCF beta-TrCP1.

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2805%2999030-7

7 January 2021

M-phase kinases induce phospho-dependent ubiquitination of somatic Wee1 by SCFbeta-TrCP

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2805%2999030-7

7 January 2021

The Fbw7 tumor suppressor regulates glycogen synthase kinase 3 phosphorylation-dependent c-Myc protein degradation

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2805%2999030-7

7 January 2021

Multisite phosphorylation by Cdk2 and GSK3 controls cyclin E degradation

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2805%2999030-7

7 January 2021

A hitchhiker's guide to the cullin ubiquitin ligases: SCF and its kin

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2805%2999030-7

7 January 2021

Structure of a beta-TrCP1-Skp1-beta-catenin complex: destruction motif binding and lysine specificity of the SCF(beta-TrCP1) ubiquitin ligase

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2805%2999030-7

7 January 2021

Phosphorylation-dependent degradation of c-Myc is mediated by the F-box protein Fbw7

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2805%2999030-7

7 January 2021

Identification of the receptor component of the IkappaBalpha-ubiquitin ligase

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2805%2999030-7

7 January 2021

Structure of the Cul1-Rbx1-Skp1-F boxSkp2 SCF ubiquitin ligase complex

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2805%2999030-7

7 January 2021

The SV40 large T antigen contains a decoy phosphodegron that mediates its interactions with Fbw7/hCdc4.

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2805%2999030-7

7 January 2021

Cdc53 targets phosphorylated G1 cyclins for degradation by the ubiquitin proteolytic pathway

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2805%2999030-7

7 January 2021

10.1016/S0076-6879(05)99030-7

Identifiers

DOI

1 reference

16 May 2018

PubMed ID

16338374

1 reference

16 May 2018