(Q53676358)

17 May 2018

title

Selective Targeting of the KRAS Codon 12 Mutation Sequence by Pyrrole-Imidazole Polyamide seco-CBI Conjugates. (English)

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17 May 2018

author name string

Rhys D Taylor

1

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17 May 2018

Anandhakumar Chandran

2

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17 May 2018

Gengo Kashiwazaki

3

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17 May 2018

Kaori Hashiya

4

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17 May 2018

Toshikazu Bando

5

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17 May 2018

Hiroki Nagase

6

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17 May 2018

Hiroshi Sugiyama

7

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17 May 2018

language of work or name

English

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publication date

26 August 2015

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17 May 2018

Chemistry—A European Journal

published in

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17 May 2018

volume

21

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17 May 2018

issue

42

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17 May 2018

page(s)

14996-15003

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17 May 2018

KRAS mutations and primary resistance of lung adenocarcinomas to gefitinib or erlotinib

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KRAS and BRAF mutations in advanced colorectal cancer are associated with poor prognosis but do not preclude benefit from oxaliplatin or irinotecan: results from the MRC FOCUS trial

21 January 2018

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Blocking oncogenic Ras signaling for cancer therapy

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Ras history: The saga continues

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Oncogenic KRAS signalling in pancreatic cancer

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Drugging the undruggable RAS: Mission possible?

21 January 2018

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Small molecule inhibition of the KRAS-PDEδ interaction impairs oncogenic KRAS signalling

21 January 2018

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K-Ras(G12C) inhibitors allosterically control GTP affinity and effector interactions

21 January 2018

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Targeting mutant KRAS for anticancer therapeutics: a review of novel small molecule modulators

21 January 2018

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Cancer: Drug for an 'undruggable' protein

21 January 2018

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Mutant KRAS in the initiation of pancreatic cancer

21 January 2018

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The KRAS oncogene: past, present, and future

21 January 2018

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KRAS codon 12 mutations occur very frequently in pancreatic adenocarcinomas

21 January 2018

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RAS oncogenes: weaving a tumorigenic web

21 January 2018

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K-ras as a target for cancer therapy

21 January 2018

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Molecular recognition of DNA by small molecules

21 January 2018

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Recognition of the DNA minor groove by pyrrole-imidazole polyamides

21 January 2018

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Programmable DNA binding oligomers for control of transcription

21 January 2018

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Expanding the recognition of the minor groove of DNA by incorporation of beta-alanine in hairpin polyamides

21 January 2018

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Hairpin versus extended DNA binding of a substituted beta-alanine linked polyamide

21 January 2018

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Requirement of beta-alanine components in sequence-specific DNA alkylation by pyrrole-imidazole conjugates with seven-base pair recognition.

21 January 2018

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Correlation of local effects of DNA sequence and position of β-alanine inserts with polyamide-DNA complex binding affinities and kinetics.

21 January 2018

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Promoter scanning of the human COX-2 gene with 8-ring polyamides: unexpected weakening of polyamide-DNA binding and selectivity by replacing an internal N-Me-pyrrole with β-alanine

21 January 2018

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Targeted suppression of EVI1 oncogene expression by sequence-specific pyrrole-imidazole polyamide.

21 January 2018

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Inhibition of transcription at a coding sequence by alkylating polyamide

21 January 2018

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Alkylation of template strand of coding region causes effective gene silencing

21 January 2018

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Sequence-specific gene silencing in mammalian cells by alkylating pyrrole-imidazole polyamides

21 January 2018

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Efficient DNA alkylation by a pyrrole-imidazole CBI conjugate with an indole linker: sequence-specific alkylation with nine-base-pair recognition.

21 January 2018

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https://api.crossref.org/works/10.1002%2FCHEM.201501870

Sequence-specific DNA alkylation targeting for Kras codon 13 mutation by pyrrole-imidazole polyamide seco-CBI conjugates

21 January 2018

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https://api.crossref.org/works/10.1002%2FCHEM.201501870

Critical roles of nardilysin in the maintenance of body temperature homoeostasis

21 January 2018

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ACB-PCR measurement of K-ras codon 12 mutant fractions in livers of Big Blue rats treated with N-hydroxy-2-acetylaminofluorene.

21 January 2018

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Modulation of DNA-polyamide interaction by β-alanine substitutions: a study of positional effects on binding affinity, kinetics and thermodynamics.

21 January 2018

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Cellular uptake of N-methylpyrrole/N-methylimidazole polyamide-dye conjugates

21 January 2018

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Molecular design of a pyrrole-imidazole hairpin polyamides for effective DNA alkylation

21 January 2018

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A rapid method for determining sequences in DNA by primed synthesis with DNA polymerase

21 January 2018

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DNA sequencing with chain-terminating inhibitors

21 January 2018

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The synthesis of oligonucleotides containing an aliphatic amino group at the 5' terminus: synthesis of fluorescent DNA primers for use in DNA sequence analysis

21 January 2018

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Fluorescence detection in automated DNA sequence analysis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCHEM.201501870

Frequency and type of KRAS mutations in routine diagnostic analysis of metastatic colorectal cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCHEM.201501870

Bind-n-Seq: high-throughput analysis of in vitro protein-DNA interactions using massively parallel sequencing.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCHEM.201501870

Guiding the design of synthetic DNA-binding molecules with massively parallel sequencing

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCHEM.201501870

Design of sequence-specific DNA binding molecules for DNA methyltransferase inhibition

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCHEM.201501870

Design of sequence-specific DNA-binding molecules

21 January 2018

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https://api.crossref.org/works/10.1002%2FCHEM.201501870

DREME: motif discovery in transcription factor ChIP-seq data

21 January 2018

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https://api.crossref.org/works/10.1002%2FCHEM.201501870

21 January 2018

Identifiers

DOI

10.1002/CHEM.201501870

1 reference

17 May 2018

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17 May 2018