(Q54117927)

25 May 2018

title

Dual mTOR/PI3K inhibition limits PI3K-dependent pathways activated upon mTOR inhibition in autosomal dominant polycystic kidney disease. (English)

1 reference

25 May 2018

autosomal dominant polycystic kidney disease

main subject

1 reference

autosomal dominant polycystic kidney

inferred from title

1 reference

Justyna Siwy

8

0 references

author name string

Yang Liu

1

1 reference

25 May 2018

Martin Pejchinovski

2

1 reference

25 May 2018

Xueqi Wang

3

1 reference

25 May 2018

Xuebin Fu

4

1 reference

25 May 2018

Deborah Castelletti

5

1 reference

25 May 2018

Terry J Watnick

6

1 reference

25 May 2018

Alexandre Arcaro

7

1 reference

25 May 2018

William Mullen

9

1 reference

25 May 2018

Harald Mischak

10

1 reference

25 May 2018

Andreas L Serra

11

1 reference

25 May 2018

language of work or name

English

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publication date

3 April 2018

1 reference

25 May 2018

published in

Scientific Reports

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25 May 2018

volume

8

1 reference

25 May 2018

issue

1

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25 May 2018

page(s)

5584

1 reference

25 May 2018

Creative Commons Attribution 4.0 International

copyright license

start time

3 April 2018

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

0 references

describes a project that uses

SQL

1 reference

26 June 2022

https://europepmc.org/article/PMC/PMC5882886

inferred from PubMed Central ID database lookup

exact match

https://scigraph.springernature.com/pub.10.1038/s41598-018-22938-x

0 references

cites work

Comparison of higher energy collisional dissociation and collision-induced dissociation MS/MS sequencing methods for identification of naturally occurring peptides in human urine

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Cyclic nucleotide signalling in kidney fibrosis

25 May 2018

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Dual phosphoinositide 3-kinase/mammalian target of rapamycin inhibitor is an effective radiosensitizer for colorectal cancer

25 May 2018

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NVP-BEZ235, a dual PI3K/mTOR inhibitor synergistically potentiates the antitumor effects of cisplatin in bladder cancer cells

25 May 2018

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Activation of the PI3K/mTOR pathway is involved in cystic proliferation of cholangiocytes of the PCK rat

25 May 2018

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FoxO transcription factors promote AKT Ser473 phosphorylation and renal tumor growth in response to pharmacologic inhibition of the PI3K-AKT pathway

25 May 2018

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Inhibition of DNA double-strand break repair by the dual PI3K/mTOR inhibitor NVP-BEZ235 as a strategy for radiosensitization of glioblastoma

25 May 2018

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Cellular mechanisms of tissue fibrosis. 6. Purinergic signaling and response in fibroblasts and tissue fibrosis

25 May 2018

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The dual PI3K/mTOR inhibitor NVP-BEZ235 is a potent inhibitor of ATM- and DNA-PKCs-mediated DNA damage responses

25 May 2018

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Dose-dependent effects of sirolimus on mTOR signaling and polycystic kidney disease

25 May 2018

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Analysis of the pharmacodynamic activity of the mTOR inhibitor ridaforolimus (AP23573, MK-8669) in a phase 1 clinical trial

25 May 2018

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Synergistic action of a RAF inhibitor and a dual PI3K/mTOR inhibitor in thyroid cancer

25 May 2018

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Limitations in small intestinal neuroendocrine tumor therapy by mTor kinase inhibition reflect growth factor-mediated PI3K feedback loop activation via ERK1/2 and AKT.

25 May 2018

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Comprehensive human urine standards for comparability and standardization in clinical proteome analysis

25 May 2018

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mTORC1/2 and rapamycin in female Han:SPRD rats with polycystic kidney disease

25 May 2018

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Crosstalk between the PI3K/mTOR and MEK/ERK pathways involved in the maintenance of self-renewal and tumorigenicity of glioblastoma stem-like cells.

25 May 2018

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Cyclic AMP controls mTOR through regulation of the dynamic interaction between Rheb and phosphodiesterase 4D.

25 May 2018

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Therapeutic mTOR inhibition in autosomal dominant polycystic kidney disease: What is the appropriate serum level?

25 May 2018

1 reference

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Compensatory activation of Akt in response to mTOR and Raf inhibitors - a rationale for dual-targeted therapy approaches in neuroendocrine tumor disease

25 May 2018

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Chronic inhibition of the mTORC1/S6K1 pathway increases insulin-induced PI3K activity but inhibits Akt2 and glucose transport stimulation in 3T3-L1 adipocytes

25 May 2018

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Rapamycin ameliorates PKD resulting from conditional inactivation of Pkd1.

25 May 2018

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Specific apoptosis induction by the dual PI3K/mTor inhibitor NVP-BEZ235 in HER2 amplified and PIK3CA mutant breast cancer cells

25 May 2018

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Dual targeting of the PI3K/Akt/mTOR pathway as an antitumor strategy in Waldenstrom macroglobulinemia.

25 May 2018

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Emerging evidence of a link between the polycystins and the mTOR pathways

25 May 2018

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Equivalent benefit of mTORC1 blockade and combined PI3K-mTOR blockade in a mouse model of tuberous sclerosis

25 May 2018

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Defects in cell polarity underlie TSC and ADPKD-associated cystogenesis

25 May 2018

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Effective use of PI3K and MEK inhibitors to treat mutant Kras G12D and PIK3CA H1047R murine lung cancers

25 May 2018

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25 May 2018

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Polycystic kidney disease

25 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5882886

Inhibition of mTORC1 leads to MAPK pathway activation through a PI3K-dependent feedback loop in human cancer

25 May 2018

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Identifying optimal biologic doses of everolimus (RAD001) in patients with cancer based on the modeling of preclinical and clinical pharmacokinetic and pharmacodynamic data

25 May 2018

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A critical developmental switch defines the kinetics of kidney cyst formation after loss of Pkd1

25 May 2018

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Rat models of autosomal dominant polycystic kidney disease

25 May 2018

1 reference

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Urinary peptidomics provides a noninvasive humanized readout of diabetic nephropathy in mice.

25 May 2018

1 reference

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Urine peptidome analysis predicts risk of end-stage renal disease and reveals proteolytic pathways involved in autosomal dominant polycystic kidney disease progression.

13 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5882886

Phase II study of dual phosphoinositol-3-kinase (PI3K) and mammalian target of rapamycin (mTOR) inhibitor BEZ235 in patients with locally advanced or metastatic transitional cell carcinoma.

13 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5882886

Everolimus in patients with autosomal dominant polycystic kidney disease.

13 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5882886

Sirolimus and kidney growth in autosomal dominant polycystic kidney disease

13 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5882886

Pulse mTOR inhibitor treatment effectively controls cyst growth but leads to severe parenchymal and glomerular hypertrophy in rat polycystic kidney disease

13 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5882886

Everolimus retards cyst growth and preserves kidney function in a rodent model for polycystic kidney disease

13 August 2018

1 reference

Crossref

https://api.crossref.org/works/10.1038%2FS41598-018-22938-X

7 January 2021

inferred from DOI database lookup

A functional floxed allele of Pkd1 that can be conditionally inactivated in vivo

1 reference

Crossref

https://api.crossref.org/works/10.1038%2FS41598-018-22938-X

7 January 2021

inferred from DOI database lookup

Identifiers

DOI

10.1038/S41598-018-22938-X

1 reference

25 May 2018

Dimensions Publication ID

0 references

1 reference

25 May 2018

PubMed ID

29615724

1 reference

25 May 2018