(Q54322921)

27 May 2018

title

Hedgehog signaling controls fibroblast activation and tissue fibrosis in systemic sclerosis. (English)

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author

Jérôme Avouac

8

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27 May 2018

Georg Schett

15

object named as

Georg Schett

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Angelika Horn

1

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Katrin Palumbo

2

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Cinzia Cordazzo

3

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Clara Dees

4

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Alfiya Akhmetshina

5

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Michal Tomcik

6

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Pawel Zerr

7

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Johannes Gusinde

9

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Jochen Zwerina

10

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Hermine Roudaut

11

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Elisabeth Traiffort

12

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Martial Ruat

13

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Oliver Distler

14

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Jörg H W Distler

16

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publication date

1 August 2012

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27 May 2018

published in

Arthritis and Rheumatism

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volume

64

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issue

8

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page(s)

2724-2733

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Systemic sclerosis: a prototypic multisystem fibrotic disorder

cites work

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21 January 2018

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Mutations affecting segment number and polarity in Drosophila

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Sonic hedgehog, a member of a family of putative signaling molecules, is implicated in the regulation of CNS polarity

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Floor plate and motor neuron induction by vhh-1, a vertebrate homolog of hedgehog expressed by the notochord

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Activation of the transcription factor Gli1 and the Sonic hedgehog signalling pathway in skin tumours

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Hedgehog signal transduction by Smoothened: pharmacologic evidence for a 2-step activation process

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Patching the gaps in Hedgehog signalling

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Cyclopia and defective axial patterning in mice lacking Sonic hedgehog gene function

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Sonic hedgehog regulates branching morphogenesis in the mammalian lung

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Altered neural cell fates and medulloblastoma in mouse patched mutants

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Basal cell carcinomas in mice overexpressing sonic hedgehog

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Activating Smoothened mutations in sporadic basal-cell carcinoma

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Basal cell carcinomas in mice overexpressing Gli2 in skin

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Hedgehog is an early and late mediator of pancreatic cancer tumorigenesis

21 January 2018

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Dual inhibition of c-abl and PDGF receptor signaling by dasatinib and nilotinib for the treatment of dermal fibrosis

21 January 2018

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Monocyte chemoattractant protein 1 released from glycosaminoglycans mediates its profibrotic effects in systemic sclerosis via the release of interleukin-4 from T cells

21 January 2018

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The induction of matrix metalloproteinase and cytokine expression in synovial fibroblasts stimulated with immune cell microparticles

21 January 2018

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Bucillamine induces the synthesis of vascular endothelial growth factor dose-dependently in systemic sclerosis fibroblasts via nuclear factor-kappaB and simian virus 40 promoter factor 1 pathways

21 January 2018

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Platelet-derived serotonin links vascular disease and tissue fibrosis

21 January 2018

1 reference

The transcription factor JunD mediates transforming growth factor {beta}-induced fibroblast activation and fibrosis in systemic sclerosis

21 January 2018

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Increase of proliferating oligodendroglial progenitors in the adult mouse brain upon Sonic hedgehog delivery in the lateral ventricle.

21 January 2018

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Ultraviolet and ionizing radiation enhance the growth of BCCs and trichoblastomas in patched heterozygous knockout mice

21 January 2018

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Inhibition of Notch signaling prevents experimental fibrosis and induces regression of established fibrosis.

21 January 2018

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Imatinib mesylate reduces production of extracellular matrix and prevents development of experimental dermal fibrosis

21 January 2018

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Inhibition of activator protein 1 signaling abrogates transforming growth factor β-mediated activation of fibroblasts and prevents experimental fibrosis.

21 January 2018

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β-catenin is a central mediator of pro-fibrotic Wnt signaling in systemic sclerosis

21 January 2018

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Hedgehog target genes: mechanisms of carcinogenesis induced by aberrant hedgehog signaling activation

21 January 2018

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TGF-β/SMAD/GLI2 signaling axis in cancer progression and metastasis

21 January 2018

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Networking of WNT, FGF, Notch, BMP, and Hedgehog signaling pathways during carcinogenesis

21 January 2018

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Biochemical evidence that patched is the Hedgehog receptor

21 January 2018

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Sonic hedgehog regulates ischemia/hypoxia-induced neural progenitor proliferation

21 January 2018

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Uncontrolled expression of vascular endothelial growth factor and its receptors leads to insufficient skin angiogenesis in patients with systemic sclerosis

21 January 2018

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Sonic hedgehog is an autocrine viability factor for myofibroblastic hepatic stellate cells

21 January 2018

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PDGF isoforms induce and maintain anagen phase of murine hair follicles.

21 January 2018

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Accumulation of hedgehog-responsive progenitors parallels alcoholic liver disease severity in mice and humans

21 January 2018

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Hedgehog-mediated epithelial-to-mesenchymal transition and fibrogenic repair in nonalcoholic fatty liver disease.

21 January 2018

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Inhibition of Hedgehog signaling enhances delivery of chemotherapy in a mouse model of pancreatic cancer

21 January 2018

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21 January 2018

Identifiers

DOI

10.1002/ART.34444

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27 May 2018

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27 May 2018