(Q54355900)

28 May 2018

title

Different substrate-dependent transition states in the active site of the ribosome. (English)

1 reference

28 May 2018

author

Marina Rodnina

series ordinal

3

1 reference

28 May 2018

Wolfgang Wintermeyer

series ordinal

2

object named as

Wolfgang Wintermeyer

1 reference

28 May 2018

Stephan Kuhlenkoetter

series ordinal

1

object named as

Stephan Kuhlenkoetter

1 reference

28 May 2018

language of work or name

English

0 references

publication date

31 July 2011

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28 May 2018

published in

Nature

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28 May 2018

volume

476

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28 May 2018

issue

7360

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28 May 2018

page(s)

351-354

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28 May 2018

The critical role of the universally conserved A2602 of 23S ribosomal RNA in the release of the nascent peptide during translation termination.

cites work

1 reference

https://api.crossref.org/works/10.1038%2FNATURE10247

The active site of the ribosome is composed of two layers of conserved nucleotides with distinct roles in peptide bond formation and peptide release

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE10247

Peptide release on the ribosome depends critically on the 2' OH of the peptidyl-tRNA substrate

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE10247

Mechanism of the translation termination reaction on the ribosome

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE10247

The transition state for peptide bond formation reveals the ribosome as a water trap

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE10247

Structure of the 70S ribosome bound to release factor 2 and a substrate analog provides insights into catalysis of peptide release

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE10247

Structural basis for translation termination on the 70S ribosome

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE10247

Insights into Translational Termination from the Structure of RF2 Bound to the Ribosome

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE10247

Crystal structure of a translation termination complex formed with release factor RF2

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE10247

Crystal Structures of the Ribosome in Complex with Release Factors RF1 and RF2 Bound to a Cognate Stop Codon

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE10247

Structural insights into the roles of water and the 2' hydroxyl of the P site tRNA in the peptidyl transferase reaction

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE10247

Two distinct components of release factor function uncovered by nucleophile partitioning analysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE10247

An intact ribose moiety at A2602 of 23S rRNA is key to trigger peptidyl-tRNA hydrolysis during translation termination.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE10247

Important contribution to catalysis of peptide bond formation by a single ionizing group within the ribosome.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE10247

An uncharged amine in the transition state of the ribosomal peptidyl transfer reaction

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE10247

Kinetic isotope effect analysis of the ribosomal peptidyl transferase reaction

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE10247

The G2447A mutation does not affect ionization of a ribosomal group taking part in peptide bond formation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE10247

Essential mechanisms in the catalysis of peptide bond formation on the ribosome.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE10247

Transition state chirality and role of the vicinal hydroxyl in the ribosomal peptidyl transferase reaction.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE10247

The ribosome as an entropy trap

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE10247

A post-translational modification in the GGQ motif of RF2 from Escherichia coli stimulates termination of translation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE10247

The accuracy of codon recognition by polypeptide release factors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE10247

The syn-oriented 2-OH provides a favorable proton transfer geometry in 1,2-diol monoester aminolysis: implications for the ribosome mechanism

21 January 2018

1 reference

12 December 2020

The essential role of the invariant GGQ motif in the function and stability in vivo of bacterial release factors RF1 and RF2

1 reference

12 December 2020

Analysis of predictions for the catalytic mechanism of ribosomal peptidyl transfer

1 reference

12 December 2020

Peptide bond formation does not involve acid-base catalysis by ribosomal residues

1 reference

12 December 2020

Identifiers

DOI

10.1038/NATURE10247

1 reference

28 May 2018

Dimensions Publication ID

1013073423

0 references

1 reference

28 May 2018