(Q54365047)

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A small-molecule benzimidazole derivative that potently activates AMPK to increase glucose transport in skeletal muscle: comparison with effects of contraction and other AMPK activators.

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scholarly article

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Europe PubMed Central

PubMed publication ID

28 May 2018

http://europepmc.org/abstract/MED/24665903

A small-molecule benzimidazole derivative that potently activates AMPK to increase glucose transport in skeletal muscle: comparison with effects of contraction and other AMPK activators. (English)

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Europe PubMed Central

PubMed publication ID

28 May 2018

http://europepmc.org/abstract/MED/24665903

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Didier Vertommen

3

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Europe PubMed Central

PubMed publication ID

28 May 2018

http://europepmc.org/abstract/MED/24665903

5

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Europe PubMed Central

PubMed publication ID

28 May 2018

http://europepmc.org/abstract/MED/24665903

6

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Europe PubMed Central

PubMed publication ID

28 May 2018

http://europepmc.org/abstract/MED/24665903

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Yu-Chiang Lai

1

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author name string

Samanta Kviklyte

2

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Europe PubMed Central

PubMed publication ID

28 May 2018

http://europepmc.org/abstract/MED/24665903

Louise Lantier

4

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Europe PubMed Central

PubMed publication ID

28 May 2018

http://europepmc.org/abstract/MED/24665903

Stefan Hallén

7

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Europe PubMed Central

PubMed publication ID

28 May 2018

http://europepmc.org/abstract/MED/24665903

Mark H Rider

8

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Europe PubMed Central

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28 May 2018

http://europepmc.org/abstract/MED/24665903

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1 June 2014

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Europe PubMed Central

PubMed publication ID

28 May 2018

http://europepmc.org/abstract/MED/24665903

Biochemical Journal

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PubMed publication ID

28 May 2018

http://europepmc.org/abstract/MED/24665903

460

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Europe PubMed Central

PubMed publication ID

28 May 2018

http://europepmc.org/abstract/MED/24665903

3

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Europe PubMed Central

PubMed publication ID

28 May 2018

http://europepmc.org/abstract/MED/24665903

363-375

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Europe PubMed Central

PubMed publication ID

28 May 2018

http://europepmc.org/abstract/MED/24665903

AMPK: a nutrient and energy sensor that maintains energy homeostasis

1 reference

https://api.crossref.org/works/10.1042%2FBJ20131673

21 January 2018

AMPK in Health and Disease

1 reference

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21 January 2018

Quantitation of muscle glycogen synthesis in normal subjects and subjects with non-insulin-dependent diabetes by 13C nuclear magnetic resonance spectroscopy.

1 reference

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21 January 2018

The role of skeletal muscle glycogen breakdown for regulation of insulin sensitivity by exercise

1 reference

https://api.crossref.org/works/10.1042%2FBJ20131673

21 January 2018

Ca2+ and AMPK both mediate stimulation of glucose transport by muscle contractions

1 reference

https://api.crossref.org/works/10.1042%2FBJ20131673

21 January 2018

A role for AMP-activated protein kinase in contraction- and hypoxia-regulated glucose transport in skeletal muscle

1 reference

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AMP-activated protein kinase (AMPK) beta1beta2 muscle null mice reveal an essential role for AMPK in maintaining mitochondrial content and glucose uptake during exercise.

1 reference

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21 January 2018

Long-term AICAR administration and exercise prevents diabetes in ZDF rats

1 reference

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21 January 2018

Knockout of the alpha2 but not alpha1 5'-AMP-activated protein kinase isoform abolishes 5-aminoimidazole-4-carboxamide-1-beta-4-ribofuranosidebut not contraction-induced glucose uptake in skeletal muscle.

1 reference

https://api.crossref.org/works/10.1042%2FBJ20131673

21 January 2018

The 5'-AMP-activated protein kinase gamma3 isoform has a key role in carbohydrate and lipid metabolism in glycolytic skeletal muscle

1 reference

https://api.crossref.org/works/10.1042%2FBJ20131673

21 January 2018

Whole body deletion of AMP-activated protein kinase {beta}2 reduces muscle AMPK activity and exercise capacity.

1 reference

https://api.crossref.org/works/10.1042%2FBJ20131673

21 January 2018

Skeletal muscle AMP-activated protein kinase is essential for the metabolic response to exercise in vivo

1 reference

https://api.crossref.org/works/10.1042%2FBJ20131673

21 January 2018

Inhibition of contraction-stimulated AMP-activated protein kinase inhibits contraction-stimulated increases in PAS-TBC1D1 and glucose transport without altering PAS-AS160 in rat skeletal muscle

1 reference

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21 January 2018

Discovery of TBC1D1 as an insulin-, AICAR-, and contraction-stimulated signaling nexus in mouse skeletal muscle.

1 reference

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21 January 2018

Phosphatidylinositol 3-phosphate 5-kinase (PIKfyve) is an AMPK target participating in contraction-stimulated glucose uptake in skeletal muscle

1 reference

https://api.crossref.org/works/10.1042%2FBJ20131673

21 January 2018

Role of AMP-activated protein kinase in mechanism of metformin action

1 reference

https://api.crossref.org/works/10.1042%2FBJ20131673

21 January 2018

Molecular mechanism of action of metformin: old or new insights?

1 reference

https://api.crossref.org/works/10.1042%2FBJ20131673

21 January 2018

5-aminoimidazole-4-carboxamide ribonucleoside. A specific method for activating AMP-activated protein kinase in intact cells?

1 reference

https://api.crossref.org/works/10.1042%2FBJ20131673

21 January 2018

Long-term AICAR administration reduces metabolic disturbances and lowers blood pressure in rats displaying features of the insulin resistance syndrome

1 reference

https://api.crossref.org/works/10.1042%2FBJ20131673

21 January 2018

5-Aminoimidazole-4-carboxamide ribonucleoside treatment improves glucose homeostasis in insulin-resistant diabetic (ob/ob) mice

1 reference

https://api.crossref.org/works/10.1042%2FBJ20131673

21 January 2018

5-aminoimidazole-4-carboxamide 1-beta-D-ribofuranoside acutely stimulates skeletal muscle 2-deoxyglucose uptake in healthy men.

1 reference

https://api.crossref.org/works/10.1042%2FBJ20131673

21 January 2018

Blunting of AICAR-induced human skeletal muscle glucose uptake in type 2 diabetes is dependent on age rather than diabetic status

1 reference

https://api.crossref.org/works/10.1042%2FBJ20131673

21 January 2018

Activation of glycogen phosphorylase and glycogenolysis in rat skeletal muscle by AICAR--an activator of AMP-activated protein kinase

1 reference

https://api.crossref.org/works/10.1042%2FBJ20131673

21 January 2018

Identification and characterization of a small molecule AMPK activator that treats key components of type 2 diabetes and the metabolic syndrome

1 reference

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21 January 2018

Defining the mechanism of activation of AMP-activated protein kinase by the small molecule A-769662, a member of the thienopyridone family.

1 reference

https://api.crossref.org/works/10.1042%2FBJ20131673

21 January 2018

Mechanism of action of A-769662, a valuable tool for activation of AMP-activated protein kinase.

1 reference

https://api.crossref.org/works/10.1042%2FBJ20131673

21 January 2018

Thienopyridone drugs are selective activators of AMP-activated protein kinase beta1-containing complexes.

1 reference

https://api.crossref.org/works/10.1042%2FBJ20131673

21 January 2018

A-769662 activates AMPK beta1-containing complexes but induces glucose uptake through a PI3-kinase-dependent pathway in mouse skeletal muscle.

1 reference

https://api.crossref.org/works/10.1042%2FBJ20131673

21 January 2018

Identification of a novel AMP-activated protein kinase beta subunit isoform that is highly expressed in skeletal muscle

1 reference

https://api.crossref.org/works/10.1042%2FBJ20131673

21 January 2018

Direct AMP-activated protein kinase activators: a review of evidence from the patent literature

1 reference

https://api.crossref.org/works/10.1042%2FBJ20131673

21 January 2018

Glycogen content and contraction regulate glycogen synthase phosphorylation and affinity for UDP-glucose in rat skeletal muscles.

1 reference

https://api.crossref.org/works/10.1042%2FBJ20131673

21 January 2018

Glycogen content regulates insulin- but not contraction-mediated glycogen synthase activation in the rat slow-twitch soleus muscles.

1 reference

https://api.crossref.org/works/10.1042%2FBJ20131673

21 January 2018

Coordinated maintenance of muscle cell size control by AMP-activated protein kinase

1 reference

https://api.crossref.org/works/10.1042%2FBJ20131673

21 January 2018

A novel PKB/Akt inhibitor, MK-2206, effectively inhibits insulin-stimulated glucose metabolism and protein synthesis in isolated rat skeletal muscle.

1 reference

https://api.crossref.org/works/10.1042%2FBJ20131673

21 January 2018

Additive effect of contraction and insulin on glucose uptake and glycogen synthase in muscle with different glycogen contents.

1 reference

https://api.crossref.org/works/10.1042%2FBJ20131673

21 January 2018

Use of alpha-toxin from Staphylococcus aureus to test for channelling of intermediates of glycolysis between glucokinase and aldolase in hepatocytes

1 reference

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A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

1 reference

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Mammalian target of rapamycin-independent S6K1 and 4E-BP1 phosphorylation during contraction in rat skeletal muscle.

1 reference

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Effects of contraction and insulin on protein synthesis, AMP-activated protein kinase and phosphorylation state of translation factors in rat skeletal muscle

1 reference

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Glycogen-dependent effects of 5-aminoimidazole-4-carboxamide (AICA)-riboside on AMP-activated protein kinase and glycogen synthase activities in rat skeletal muscle

1 reference

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21 January 2018

Activation of AMP-activated protein kinase revealed by hydrogen/deuterium exchange mass spectrometry

1 reference

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21 January 2018

Expression profiling of the gamma-subunit isoforms of AMP-activated protein kinase suggests a major role for gamma3 in white skeletal muscle

1 reference

https://api.crossref.org/works/10.1042%2FBJ20131673

21 January 2018

Single phosphorylation sites in Acc1 and Acc2 regulate lipid homeostasis and the insulin-sensitizing effects of metformin.

1 reference

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A Ca(2+)-calmodulin-eEF2K-eEF2 signalling cascade, but not AMPK, contributes to the suppression of skeletal muscle protein synthesis during contractions

1 reference

https://api.crossref.org/works/10.1042%2FBJ20131673

21 January 2018

5-Aminoimidazole-4-Carboxamide-1- -D-Ribofuranoside and Metformin Inhibit Hepatic Glucose Phosphorylation by an AMP-Activated Protein Kinase-Independent Effect on Glucokinase Translocation

1 reference

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21 January 2018

Identifiers

10.1042/BJ20131673

1 reference

Europe PubMed Central

PubMed publication ID

28 May 2018

http://europepmc.org/abstract/MED/24665903

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

28 May 2018

http://europepmc.org/abstract/MED/24665903

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