(Q54430665)

29 May 2018

title

Thymidylate synthase inhibition induces p53-dependent and p53-independent apoptotic responses in human urinary bladder cancer cells. (English)

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29 May 2018

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Dimitrios J Stravopodis

1

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29 May 2018

Lukas H. Margaritis

7

object named as

Lukas H Margaritis

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29 May 2018

Panagiotis K Karkoulis

2

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29 May 2018

Eumorphia G Konstantakou

3

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29 May 2018

Sophia Melachroinou

4

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29 May 2018

Angeliki Thanasopoulou

5

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29 May 2018

Gerasimos Aravantinos

6

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29 May 2018

Ema Anastasiadou

8

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29 May 2018

Gerassimos E Voutsinas

9

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29 May 2018

publication date

28 April 2010

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29 May 2018

Journal of Cancer Research and Clinical Oncology

published in

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29 May 2018

volume

137

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29 May 2018

page(s)

359-374

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29 May 2018

issue

2

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29 May 2018

https://scigraph.springernature.com/pub.10.1007/s00432-010-0891-y

exact match

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cites work

Retinoblastoma tumor suppressor targets dNTP metabolism to regulate DNA replication

1 reference

https://api.crossref.org/works/10.1007%2FS00432-010-0891-Y

GraBCas: a bioinformatics tool for score-based prediction of Caspase- and Granzyme B-cleavage sites in protein sequences

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00432-010-0891-Y

Thymidylate synthase inhibition triggers apoptosis via caspases-8 and -9 in both wild-type and mutant p53 colon cancer cell lines

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00432-010-0891-Y

Uracil in DNA: consequences for carcinogenesis and chemotherapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00432-010-0891-Y

Inhibition of Fas expression by RNAi modulates 5-fluorouracil-induced apoptosis in HCT116 cells expressing wild-type p53.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00432-010-0891-Y

Characterization of p53 wild-type and null isogenic colorectal cancer cell lines resistant to 5-fluorouracil, oxaliplatin, and irinotecan

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00432-010-0891-Y

Disruption of p53 in human cancer cells alters the responses to therapeutic agents

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00432-010-0891-Y

Prognostic value of proliferation, apoptosis, defective DNA mismatch repair, and p53 overexpression in patients with resected Dukes' B2 or C colon cancer: a North Central Cancer Treatment Group Study

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00432-010-0891-Y

Systemic and targeted therapy for advanced colon cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00432-010-0891-Y

Life and death decisions by the E2F transcription factors

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00432-010-0891-Y

Intratumoural thymidylate synthase and dihydropyrimidine dehydrogenase activities are good predictors of 5-fluorouracil sensitivity in colorectal cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00432-010-0891-Y

Expression of thymidylate synthase in human cells is an early G(1) event regulated by CDK4 and p16INK4A but not E2F.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00432-010-0891-Y

Weekly cisplatin plus infusional high-dose 5-fluorouracil and leucovorin (P-HDFL) for metastatic urothelial carcinoma: an effective regimen with low toxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00432-010-0891-Y

5-fluorouracil mediates apoptosis and G1/S arrest in laryngeal squamous cell carcinoma via a p53-independent pathway.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00432-010-0891-Y

5-Fluorouracil: mechanisms of action and clinical strategies

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00432-010-0891-Y

Posttranslational phosphorylation of mutant p53 protein in tumor development

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00432-010-0891-Y

Prognostic significance of thymidylate synthase activity in bladder carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00432-010-0891-Y

Prognostic significance of orotate phosphoribosyltransferase activity in bladder carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00432-010-0891-Y

Identification of novel genes associated with the response to 5-FU treatment in gastric cancer cell lines using a cDNA microarray

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00432-010-0891-Y

Induction of thymidylate synthase as a 5-fluorouracil resistance mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00432-010-0891-Y

Cyclin-dependent kinases are inactivated by a combination of p21 and Thr-14/Tyr-15 phosphorylation after UV-induced DNA damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00432-010-0891-Y

E2F1 death pathways as targets for cancer therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00432-010-0891-Y

Transcriptional activation of the proapoptotic bik gene by E2F proteins in cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00432-010-0891-Y

RB activity alters checkpoint response and chemosensitivity in lung cancer lines

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00432-010-0891-Y

Transcriptional control of human p53-regulated genes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00432-010-0891-Y

DNA damage-induced cell death by apoptosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00432-010-0891-Y

Thymidylate synthase: a critical target in cancer therapy?

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00432-010-0891-Y

Prognostic significance of thymidylate synthase, dihydropyrimidine dehydrogenase and thymidine phosphorylase protein expression in colorectal cancer patients treated with or without 5-fluorouracil-based chemotherapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00432-010-0891-Y

The emerging role of E2F-1 in the DNA damage response and checkpoint control

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00432-010-0891-Y

Drug-mediated targeted disruption of multiple protein activities through functional inhibition of the Hsp90 chaperone complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00432-010-0891-Y

Effect of caspase cleavage-site phosphorylation on proteolysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00432-010-0891-Y

Downstream molecular determinants of response to 5-fluorouracil and antifolate thymidylate synthase inhibitors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00432-010-0891-Y

Outcomes of p53 activation--spoilt for choice

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00432-010-0891-Y

Disulfiram-mediated inhibition of NF-kappaB activity enhances cytotoxicity of 5-fluorouracil in human colorectal cancer cell lines

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00432-010-0891-Y

Mechanisms of acquired chemoresistance to 5-fluorouracil and tomudex: thymidylate synthase dependent and independent networks.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00432-010-0891-Y

A global map of p53 transcription-factor binding sites in the human genome

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00432-010-0891-Y

Determination of TP53 mutation is more relevant than microsatellite instability status for the prediction of disease-free survival in adjuvant-treated stage III colon cancer patients.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00432-010-0891-Y

HSP90 and the chaperoning of cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00432-010-0891-Y

Participation of DNA repair in the response to 5-fluorouracil

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00432-010-0891-Y

Activation of the p53 tumor suppressor protein

21 January 2018

1 reference

12 December 2020

Colorectal tumors responding to 5-fluorouracil have low gene expression levels of dihydropyrimidine dehydrogenase, thymidylate synthase, and thymidine phosphorylase.

1 reference

12 December 2020

Correlation of thymidylate synthase, thymidine phosphorylase and dihydropyrimidine dehydrogenase with sensitivity of gastrointestinal cancer cells to 5-fluorouracil and 5-fluoro-2'-deoxyuridine

1 reference

12 December 2020

Radiochemotherapy with cisplatin and 5-fluorouracil after transurethral surgery in patients with bladder cancer

1 reference

12 December 2020

Human bladder cancer cells undergo cisplatin-induced apoptosis that is associated with p53-dependent and p53-independent responses

1 reference

12 December 2020

Role of the hMLH1 DNA mismatch repair protein in fluoropyrimidine-mediated cell death and cell cycle responses.

1 reference

12 December 2020

Thymidylate synthase, dihydropyrimidine dehydrogenase, orotate phosphoribosyltransferase mRNA and protein expression levels in solid tumors in large scale population analysis.

1 reference

12 December 2020

Relationship between expression of 5-fluorouracil metabolic enzymes and 5-fluorouracil sensitivity in esophageal carcinoma cell lines

1 reference

12 December 2020

Overexpression of p53 is not associated with drug resistance of gastric cancers to 5-fluorouracil-based systemic chemotherapy

1 reference

12 December 2020

Transcriptional control elements and complex initiation pattern of the TATA-less bidirectional human thymidylate synthase promoter

1 reference

12 December 2020

Expression level of thymidylate synthase mRNA reflects 5-fluorouracil sensitivity with low dose and long duration in primary colorectal cancer

1 reference

12 December 2020

Thymidine phosphorylase activity in human bladder cancer: difference between superficial and invasive cancer

1 reference

12 December 2020

Ki-ras mutation and p53 overexpression predict the clinical behavior of colorectal cancer: a Southwest Oncology Group study.

1 reference

12 December 2020

Grade-dependent effects on cell cycle progression and apoptosis in response to doxorubicin in human bladder cancer cell lines.

1 reference

12 December 2020

Immunohistochemical determination of p53 protein does not predict clinical response in advanced colorectal cancer with low thymidylate synthase expression receiving a bolus 5-fluorouracil-leucovorin combination

1 reference

12 December 2020

Thymidylate synthase gene and protein expression correlate and are associated with response to 5-fluorouracil in human colorectal and gastric tumors

1 reference

12 December 2020

p53 point mutations and thymidylate synthase messenger RNA levels in disseminated colorectal cancer: an analysis of response and survival.

1 reference

12 December 2020

Apoptosis, cell cycle progression and gene expression in TP53-depleted HCT116 colon cancer cells in response to short-term 5-fluorouracil treatment.

1 reference

12 December 2020

mRNA expression levels of E2F transcription factors correlate with dihydrofolate reductase, reduced folate carrier, and thymidylate synthase mRNA expression in osteosarcoma.

1 reference

12 December 2020

p53 dependence and apoptosis in response to FP treatment with p53-transfected colon cancer cell lines by use of thin layer collagen gel.

1 reference

12 December 2020

10.1007/S00432-010-0891-Y

Identifiers

DOI

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29 May 2018

PubMed ID

20425122

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29 May 2018