(Q54496603)

30 May 2018

title

Class IA phosphatidylinositol 3-kinase regulates osteoclastic bone resorption through protein kinase B-mediated vesicle transport. (English)

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30 May 2018

author

Sakae Tanaka

13

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30 May 2018

author name string

Masahiro Shinohara

1

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30 May 2018

Masaki Nakamura

2

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30 May 2018

Hironari Masuda

3

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30 May 2018

Jun Hirose

4

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30 May 2018

Yuho Kadono

5

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30 May 2018

Mitsuyasu Iwasawa

6

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30 May 2018

Yuuichi Nagase

7

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30 May 2018

Kohjiro Ueki

8

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30 May 2018

Takashi Kadowaki

9

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30 May 2018

Takehiko Sasaki

10

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30 May 2018

Shigeaki Kato

11

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30 May 2018

Hiroaki Nakamura

12

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30 May 2018

Hiroshi Takayanagi

14

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30 May 2018

publication date

1 December 2012

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30 May 2018

Journal of Bone and Mineral Research

published in

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30 May 2018

volume

27

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30 May 2018

issue

12

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30 May 2018

page(s)

2464-2475

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30 May 2018

Reaching a genetic and molecular understanding of skeletal development

cites work

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Osteoimmunology: shared mechanisms and crosstalk between the immune and bone systems

21 January 2018

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Therapeutic approaches to bone diseases

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RANK-L and RANK: T cells, bone loss, and mammalian evolution

21 January 2018

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Role of RANKL in physiological and pathological bone resorption and therapeutics targeting the RANKL-RANK signaling system

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Osteoimmunology and the effects of the immune system on bone

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Osteoclast precursors, RANKL/RANK, and immunology

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The role(s) of Src kinase and Cbl proteins in the regulation of osteoclast differentiation and function

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alphavbeta3 and macrophage colony-stimulating factor: partners in osteoclast biology

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Genetic regulation of osteoclast development and function

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Synaptotagmin VII regulates bone remodeling by modulating osteoclast and osteoblast secretion

21 January 2018

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Targeted disruption of the c-src proto-oncogene leads to osteopetrosis in mice

21 January 2018

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Cellular function of phosphoinositide 3-kinases: implications for development, homeostasis, and cancer.

21 January 2018

1 reference

The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism

21 January 2018

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The emerging mechanisms of isoform-specific PI3K signalling

21 January 2018

1 reference

21 January 2018

Phosphoinositide kinases

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Regulation of phosphoinositide 3-kinase expression in health and disease

21 January 2018

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SH2 domains recognize specific phosphopeptide sequences

21 January 2018

1 reference

The role of PI3K in immune cells

21 January 2018

1 reference

PI3K in lymphocyte development, differentiation and activation

21 January 2018

1 reference

The phosphatidylinositol 3-kinase, p38, and extracellular signal-regulated kinase pathways are involved in osteoclast differentiation

21 January 2018

1 reference

Wortmannin, a specific inhibitor of phosphatidylinositol-3 kinase, blocks osteoclastic bone resorption.

21 January 2018

1 reference

Isoform-specific phosphoinositide 3-kinase inhibitors from an arylmorpholine scaffold

21 January 2018

1 reference

Class IA phosphoinositide 3-kinase regulates heart size and physiological cardiac hypertrophy

21 January 2018

1 reference

Increased insulin sensitivity in mice lacking p85beta subunit of phosphoinositide 3-kinase

21 January 2018

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Estrogen prevents bone loss via estrogen receptor alpha and induction of Fas ligand in osteoclasts

21 January 2018

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Control of cell polarity and motility by the PtdIns(3,4,5)P3 phosphatase SHIP1

21 January 2018

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Guidelines for assessment of bone microstructure in rodents using micro-computed tomography

21 January 2018

1 reference

Bone histomorphometry: standardization of nomenclature, symbols, and units. Report of the ASBMR Histomorphometry Nomenclature Committee

21 January 2018

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Tyrosine kinases Btk and Tec regulate osteoclast differentiation by linking RANK and ITAM signals.

21 January 2018

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Regulation of osteoclast apoptosis and motility by small GTPase binding protein Rac1.

21 January 2018

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Actin cytoskeletal organisation in osteoclasts: a model to decipher transmigration and matrix degradation

21 January 2018

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Direct regulation of the Akt proto-oncogene product by phosphatidylinositol-3,4-bisphosphate

21 January 2018

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Ins (endocytosis) and outs (exocytosis) of GLUT4 trafficking

21 January 2018

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Insulin receptor substrate 1 binds two novel splice variants of the regulatory subunit of phosphatidylinositol 3-kinase in muscle and brain

21 January 2018

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Increased insulin sensitivity and hypoglycaemia in mice lacking the p85 alpha subunit of phosphoinositide 3-kinase

21 January 2018

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The p85alpha subunit of class IA phosphatidylinositol 3-kinase regulates the expression of multiple genes involved in osteoclast maturation and migration

21 January 2018

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Bcl2 regulation by the melanocyte master regulator Mitf modulates lineage survival and melanoma cell viability

21 January 2018

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Podosomes display actin turnover and dynamic self-organization in osteoclasts expressing actin-green fluorescent protein

21 January 2018

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Podosome and sealing zone: specificity of the osteoclast model

21 January 2018

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The tyrosine kinase activity of c-Src regulates actin dynamics and organization of podosomes in osteoclasts

21 January 2018

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Polarized secretion of lysosomal enzymes: co-distribution of cation-independent mannose-6-phosphate receptors and lysosomal enzymes along the osteoclast exocytic pathway

21 January 2018

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The Rab GTPase-activating protein AS160 integrates Akt, protein kinase C, and AMP-activated protein kinase signals regulating GLUT4 traffic.

21 January 2018

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Regulation of membrane traffic by phosphoinositide 3-kinases

21 January 2018

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PI 3-kinase p110beta: a new target for antithrombotic therapy

21 January 2018

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Fine tuning the immune response with PI3K.

21 January 2018

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Antitumor activity of ZSTK474, a new phosphatidylinositol 3-kinase inhibitor

21 January 2018

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Inhibitory effects of ZSTK474, a novel phosphoinositide 3-kinase inhibitor, on osteoclasts and collagen-induced arthritis in mice

21 January 2018

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Targeting the PI3K signaling pathway in cancer

21 January 2018

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Targeting phosphoinositide 3-kinase: moving towards therapy

21 January 2018

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Interfering with resistance to smoothened antagonists by inhibition of the PI3K pathway in medulloblastoma.

21 January 2018

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Identification and characterization of NVP-BEZ235, a new orally available dual phosphatidylinositol 3-kinase/mammalian target of rapamycin inhibitor with potent in vivo antitumor activity

21 January 2018

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The identification of 2-(1H-indazol-4-yl)-6-(4-methanesulfonyl-piperazin-1-ylmethyl)-4-morpholin-4-yl-thieno[3,2-d]pyrimidine (GDC-0941) as a potent, selective, orally bioavailable inhibitor of class I PI3 kinase for the treatment of cancer

21 January 2018

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Cancer to bone: a fatal attraction

21 January 2018

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c-Fms Tyrosine 559 Is a Major Mediator of M-CSF-induced Proliferation of Primary Macrophages

21 January 2018

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21 January 2018

Identifiers

DOI

10.1002/JBMR.1703

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30 May 2018

PubMed ID

22806988

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30 May 2018