(Q54566875)

1 June 2018

title

Induction of autophagy with catalytic mTOR inhibitors reduces huntingtin aggregates in a neuronal cell model. (English)

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1 June 2018

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5

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author name string

Ana Roscic

1

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1 June 2018

Barbara Baldo

2

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Christophe Crochemore

3

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David Marcellin

4

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language of work or name

English

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publication date

20 September 2011

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1 June 2018

Journal of Neurochemistry

published in

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volume

119

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issue

2

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page(s)

398-407

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1 June 2018

Dual mTORC2/mTORC1 targeting results in potent suppressive effects on acute myeloid leukemia (AML) progenitors

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Chaperone-mediated autophagy in protein quality control

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Vertical targeting of the phosphatidylinositol-3 kinase pathway as a strategy for treating melanoma

21 January 2018

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Proteasome impairment does not contribute to pathogenesis in R6/2 Huntington's disease mice: exclusion of proteasome activator REGgamma as a therapeutic target

21 January 2018

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Clinical correlates of dementia and disability in Huntington's disease.

21 January 2018

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AZD8055 is a potent, selective, and orally bioavailable ATP-competitive mammalian target of rapamycin kinase inhibitor with in vitro and in vivo antitumor activity

21 January 2018

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Intracellular protein degradation from a vague idea through the lysosome and the ubiquitin-proteasome system and on to human diseases and drug targeting: Nobel Lecture, December 8, 2004.

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1471-4159.2011.07435.X

Aggregation of huntingtin in neuronal intranuclear inclusions and dystrophic neurites in brain

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1471-4159.2011.07435.X

Small changes, big impact: posttranslational modifications and function of huntingtin in Huntington disease.

21 January 2018

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The mTOR kinase inhibitor Everolimus decreases S6 kinase phosphorylation but fails to reduce mutant huntingtin levels in brain and is not neuroprotective in the R6/2 mouse model of Huntington's disease

21 January 2018

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Ku-0063794 is a specific inhibitor of the mammalian target of rapamycin (mTOR)

21 January 2018

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Raptor, a binding partner of target of rapamycin (TOR), mediates TOR action

21 January 2018

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Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive

21 January 2018

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LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing

21 January 2018

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mTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machinery

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1471-4159.2011.07435.X

Huntingtin and the molecular pathogenesis of Huntington's disease. Fourth in molecular medicine review series

21 January 2018

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Proteolysis of mutant huntingtin produces an exon 1 fragment that accumulates as an aggregated protein in neuronal nuclei in Huntington disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2011.07435.X

Mutant ubiquitin found in neurodegenerative disorders is a ubiquitin fusion degradation substrate that blocks proteasomal degradation

21 January 2018

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Identification and characterization of NVP-BEZ235, a new orally available dual phosphatidylinositol 3-kinase/mammalian target of rapamycin inhibitor with potent in vivo antitumor activity

21 January 2018

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Autophagy and neurodegeneration: when the cleaning crew goes on strike

21 January 2018

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Autophagy fights disease through cellular self-digestion

21 January 2018

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Regulation of macroautophagy by mTOR and Beclin 1 complexes

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1471-4159.2011.07435.X

Differential expression of normal and mutant Huntington's disease gene alleles

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1471-4159.2011.07435.X

Inhibition of mTOR induces autophagy and reduces toxicity of polyglutamine expansions in fly and mouse models of Huntington disease

21 January 2018

1 reference

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Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1471-4159.2011.07435.X

Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1471-4159.2011.07435.X

Small molecule enhancers of autophagy for neurodegenerative diseases

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1471-4159.2011.07435.X

Small molecules enhance autophagy and reduce toxicity in Huntington's disease models.

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1471-4159.2011.07435.X

Trehalose, a novel mTOR-independent autophagy enhancer, accelerates the clearance of mutant huntingtin and alpha-synuclein.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2011.07435.X

Huntingtin phosphorylation sites mapped by mass spectrometry. Modulation of cleavage and toxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2011.07435.X

A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2011.07435.X

A small-molecule scaffold induces autophagy in primary neurons and protects against toxicity in a Huntington disease model.

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1471-4159.2011.07435.X

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1471-4159.2011.07435.X

mTORC1 signaling: what we still don't know

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1471-4159.2011.07435.X

Inducible mutant huntingtin expression in HN10 cells reproduces Huntington's disease-like neuronal dysfunction

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1471-4159.2011.07435.X

Single-step detection of mutant huntingtin in animal and human tissues: a bioassay for Huntington's disease

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1471-4159.2011.07435.X

A new multiphasic buffer system for sodium dodecyl sulfate-polyacrylamide gel electrophoresis of proteins and peptides with molecular masses 100,000-1000, and their detection with picomolar sensitivity

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1471-4159.2011.07435.X

TOR signaling in growth and metabolism

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1471-4159.2011.07435.X

Reversal of neuropathology and motor dysfunction in a conditional model of Huntington's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2011.07435.X

10.1111/J.1471-4159.2011.07435.X

21 January 2018

Identifiers

DOI

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1 June 2018

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1 June 2018