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Small changes, big impact: posttranslational modifications and function of huntingtin in Huntington disease.
scientific article published on 10 February 2011
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scholarly article
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Europe PubMed Central
PMCID
3200085
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21311053%20AND%20SRC:MED&resulttype=core&format=json
retrieved
22 January 2020
review article
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Europe PubMed Central
title
Small changes, big impact: posttranslational modifications and function of huntingtin in Huntington disease
(English)
1 reference
stated in
Europe PubMed Central
PMCID
3200085
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21311053%20AND%20SRC:MED&resulttype=core&format=json
retrieved
22 January 2020
main subject
Huntington's disease
0 references
author
Dagmar E Ehrnhoefer
series ordinal
1
1 reference
stated in
Europe PubMed Central
PMCID
3200085
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21311053%20AND%20SRC:MED&resulttype=core&format=json
retrieved
22 January 2020
Michael R. Hayden
series ordinal
3
1 reference
stated in
Europe PubMed Central
PMCID
3200085
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21311053%20AND%20SRC:MED&resulttype=core&format=json
retrieved
22 January 2020
author name string
Liza Sutton
series ordinal
2
1 reference
stated in
Europe PubMed Central
PMCID
3200085
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21311053%20AND%20SRC:MED&resulttype=core&format=json
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22 January 2020
publication date
10 February 2011
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Europe PubMed Central
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3200085
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21311053%20AND%20SRC:MED&resulttype=core&format=json
retrieved
22 January 2020
published in
The Neuroscientist
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stated in
Europe PubMed Central
PMCID
3200085
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21311053%20AND%20SRC:MED&resulttype=core&format=json
retrieved
22 January 2020
volume
17
1 reference
stated in
Europe PubMed Central
PMCID
3200085
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21311053%20AND%20SRC:MED&resulttype=core&format=json
retrieved
22 January 2020
page(s)
475-492
1 reference
stated in
Europe PubMed Central
PMCID
3200085
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21311053%20AND%20SRC:MED&resulttype=core&format=json
retrieved
22 January 2020
issue
5
1 reference
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Europe PubMed Central
PMCID
3200085
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21311053%20AND%20SRC:MED&resulttype=core&format=json
retrieved
22 January 2020
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p300 and p300/cAMP-response element-binding protein-associated factor acetylate the androgen receptor at sites governing hormone-dependent transactivation
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Caspases and neurodegeneration: on the cutting edge of new therapeutic approaches.
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Rhes: A striatal-specific Ras homolog related to Dexras1
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alpha-bungarotoxin receptors contain alpha7 subunits in two different disulfide-bonded conformations
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3200085
retrieved
6 September 2017
Cleavage of atrophin-1 at caspase site aspartic acid 109 modulates cytotoxicity
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3200085
retrieved
6 September 2017
Caspase cleavage of gene products associated with triplet expansion disorders generates truncated fragments containing the polyglutamine tract
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3200085
retrieved
6 September 2017
Dentatorubral pallidoluysian atrophy (DRPLA) protein is cleaved by caspase-3 during apoptosis
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3200085
retrieved
6 September 2017
Aggregation of huntingtin in neuronal intranuclear inclusions and dystrophic neurites in brain
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3200085
retrieved
6 September 2017
Huntingtin is ubiquitinated and interacts with a specific ubiquitin-conjugating enzyme
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3200085
retrieved
6 September 2017
Activity and expression pattern of cyclin-dependent kinase 5 in the embryonic mouse nervous system.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3200085
retrieved
6 September 2017
Activation of specific apoptotic caspases with an engineered small-molecule-activated protease
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3200085
retrieved
14 September 2017
Palmitoylation and function of glial glutamate transporter-1 is reduced in the YAC128 mouse model of Huntington disease
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3200085
retrieved
14 September 2017
Matrix metalloproteinases are modifiers of huntingtin proteolysis and toxicity in Huntington's disease
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3200085
retrieved
14 September 2017
Oxidative stress-enhanced SUMOylation and aggregation of ataxin-1: Implication of JNK pathway
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3200085
retrieved
14 September 2017
Mutant huntingtin N-terminal fragments of specific size mediate aggregation and toxicity in neuronal cells
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3200085
retrieved
14 September 2017
Phosphorylation of mutant huntingtin at S421 restores anterograde and retrograde transport in neurons.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3200085
retrieved
14 September 2017
Intrabodies binding the proline-rich domains of mutant huntingtin increase its turnover and reduce neurotoxicity
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3200085
retrieved
14 September 2017
Proteolytic cleavage of ataxin-7 by caspase-7 modulates cellular toxicity and transcriptional dysregulation
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3200085
retrieved
14 September 2017
Phosphorylation of huntingtin by cyclin-dependent kinase 5 is induced by DNA damage and regulates wild-type and mutant huntingtin toxicity in neurons.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3200085
retrieved
14 September 2017
Heat shock protein 70 alters the endosome-lysosomal localization of huntingtin
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3200085
retrieved
14 September 2017
Expression and characterization of full-length human huntingtin, an elongated HEAT repeat protein
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3200085
retrieved
14 September 2017
Proteolytic cleavage of polyglutamine-expanded ataxin-3 is critical for aggregation and sequestration of non-expanded ataxin-3.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3200085
retrieved
14 September 2017
Co-chaperone CHIP associates with expanded polyglutamine protein and promotes their degradation by proteasomes.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3200085
retrieved
14 September 2017
The role of palmitoylation in functional expression of nicotinic alpha7 receptors.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3200085
retrieved
14 September 2017
Mutant huntingtin directly increases susceptibility of mitochondria to the calcium-induced permeability transition and cytochrome c release
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3200085
retrieved
14 September 2017
Critical loss of CBP/p300 histone acetylase activity by caspase-6 during neurodegeneration.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3200085
retrieved
14 September 2017
Parkin facilitates the elimination of expanded polyglutamine proteins and leads to preservation of proteasome function.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3200085
retrieved
14 September 2017
Proteases acting on mutant huntingtin generate cleaved products that differentially build up cytoplasmic and nuclear inclusions
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3200085
retrieved
28 September 2017
Calpain activation in Huntington's disease.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3200085
retrieved
28 September 2017
Inhibiting caspase cleavage of huntingtin reduces toxicity and aggregate formation in neuronal and nonneuronal cells
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3200085
retrieved
28 September 2017
A second cytotoxic proteolytic peptide derived from amyloid beta-protein precursor
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3200085
retrieved
28 September 2017
Evidence for a recruitment and sequestration mechanism in Huntington's disease
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3200085
retrieved
28 September 2017
The influence of huntingtin protein size on nuclear localization and cellular toxicity.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3200085
retrieved
28 September 2017
Cleavage of huntingtin by apopain, a proapoptotic cysteine protease, is modulated by the polyglutamine tract
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3200085
retrieved
28 September 2017
The identification of a functional nuclear localization signal in the Huntington disease protein
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3200085
retrieved
28 September 2017
Phosphorylation of huntingtin at Ser421 in YAC128 neurons is associated with protection of YAC128 neurons from NMDA-mediated excitotoxicity and is modulated by PP1 and PP2A.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3200085
retrieved
23 June 2018
Acetylation targets mutant huntingtin to autophagosomes for degradation
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3200085
retrieved
23 June 2018
Cdk5 phosphorylation of huntingtin reduces its cleavage by caspases: implications for mutant huntingtin toxicity
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3200085
retrieved
23 June 2018
Widespread expression of the human and rat Huntington's disease gene in brain and nonneural tissues
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3200085
retrieved
23 June 2018
Abnormalities of striatal projection neurons and N-methyl-D-aspartate receptors in presymptomatic Huntington's disease
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3200085
retrieved
23 June 2018
Huntington's disease.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3200085
retrieved
1 September 2018
Genetically engineered mesenchymal stem cells reduce behavioral deficits in the YAC 128 mouse model of Huntington's disease
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3200085
retrieved
1 September 2018
Axonal degeneration is regulated by the apoptotic machinery or a NAD+-sensitive pathway in insects and mammals.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3200085
retrieved
1 September 2018
p75NTR-dependent, myelin-mediated axonal degeneration regulates neural connectivity in the adult brain
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3200085
retrieved
1 September 2018
Phosphorylation of huntingtin reduces the accumulation of its nuclear fragments
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3200085
retrieved
1 September 2018
N-terminal proteolysis of full-length mutant huntingtin in an inducible PC12 cell model of Huntington's disease
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3200085
retrieved
1 September 2018
A conserved mechanism for steroid receptor translocation to the plasma membrane
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3200085
retrieved
1 September 2018
Wild-type huntingtin participates in protein trafficking between the Golgi and the extracellular space
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3200085
retrieved
1 September 2018
The first 17 amino acids of Huntingtin modulate its sub-cellular localization, aggregation and effects on calcium homeostasis.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3200085
retrieved
1 September 2018
Soluble androgen receptor oligomers underlie pathology in a mouse model of spinobulbar muscular atrophy
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3200085
retrieved
1 September 2018
Cleavage at the caspase-6 site is required for neuronal dysfunction and degeneration due to mutant huntingtin
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3200085
retrieved
1 September 2018
Wild-type huntingtin protects neurons from excitotoxicity
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3200085
retrieved
1 September 2018
Oligoproline effects on polyglutamine conformation and aggregation
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3200085
retrieved
1 September 2018
Levels of mutant huntingtin influence the phenotypic severity of Huntington disease in YAC128 mouse models
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3200085
retrieved
1 September 2018
Huntingtin phosphorylation on serine 421 is significantly reduced in the striatum and by polyglutamine expansion in vivo
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3200085
retrieved
1 September 2018
Regulation of histone acetylation during memory formation in the hippocampus.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3200085
retrieved
1 September 2018
Caspase-mediated proteolysis of the polyglutamine disease protein ataxin-3.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3200085
retrieved
1 September 2018
Early striatal dendrite deficits followed by neuron loss with advanced age in the absence of anterograde cortical brain-derived neurotrophic factor.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3200085
retrieved
1 September 2018
Specific caspase interactions and amplification are involved in selective neuronal vulnerability in Huntington's disease
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3200085
retrieved
1 September 2018
Enhanced Akt signaling is an early pro-survival response that reflects N-methyl-D-aspartate receptor activation in Huntington's disease knock-in striatal cells
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3200085
retrieved
1 September 2018
Depletion of wild-type huntingtin in mouse models of neurologic diseases
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3200085
retrieved
1 September 2018
Serine 776 of ataxin-1 is critical for polyglutamine-induced disease in SCA1 transgenic mice
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3200085
retrieved
1 September 2018
SUMO-1 co-localized with mutant atrophin-1 with expanded polyglutamines accelerates intranuclear aggregation and cell death.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3200085
retrieved
1 September 2018
Genetic modulation of polyglutamine toxicity by protein conjugation pathways in Drosophila
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3200085
retrieved
1 September 2018
Polyglutamine-expanded ataxin-7 promotes non-cell-autonomous purkinje cell degeneration and displays proteolytic cleavage in ataxic transgenic mice.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3200085
retrieved
1 September 2018
The IGF-1/Akt pathway is neuroprotective in Huntington's disease and involves Huntingtin phosphorylation by Akt.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3200085
retrieved
1 September 2018
Enhanced SUMOylation in polyglutamine diseases.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3200085
retrieved
1 September 2018
Increased sensitivity to N-methyl-D-aspartate receptor-mediated excitotoxicity in a mouse model of Huntington's disease
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3200085
retrieved
1 September 2018
Tissue-specific proteolysis of Huntingtin (htt) in human brain: evidence of enhanced levels of N- and C-terminal htt fragments in Huntington's disease striatum.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3200085
retrieved
1 September 2018
Mutant huntingtin expression in clonal striatal cells: dissociation of inclusion formation and neuronal survival by caspase inhibition.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3200085
retrieved
1 September 2018
Huntingtin acts in the nucleus to induce apoptosis but death does not correlate with the formation of intranuclear inclusions.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3200085
retrieved
1 September 2018
Akt blocks ligand binding and protects against expanded polyglutamine androgen receptor toxicity
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3200085
retrieved
3 December 2018
Caspase-3 cleaves the expanded androgen receptor protein of spinal and bulbar muscular atrophy in a polyglutamine repeat length-dependent manner
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/21311053
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Identifiers
DOI
10.1177/1073858410390378
1 reference
stated in
Europe PubMed Central
PMCID
3200085
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21311053%20AND%20SRC:MED&resulttype=core&format=json
retrieved
22 January 2020
Fatcat ID
release_7rp52t3dsjfatkrka5366m4j5m
1 reference
stated in
Fatcat
reference URL
https://api.fatcat.wiki/v0/release/7rp52t3dsjfatkrka5366m4j5m
retrieved
24 November 2022
based on heuristic
mapped directly with Wikidata item
PMCID
3200085
1 reference
stated in
Europe PubMed Central
PMCID
3200085
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21311053%20AND%20SRC:MED&resulttype=core&format=json
retrieved
22 January 2020
PubMed ID
21311053
1 reference
stated in
Europe PubMed Central
PMCID
3200085
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21311053%20AND%20SRC:MED&resulttype=core&format=json
retrieved
22 January 2020
ResearchGate publication ID
49826606
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