(Q40103515)

17 September 2017

Proteolytic cleavage of ataxin-7 by caspase-7 modulates cellular toxicity and transcriptional dysregulation (English)

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transcriptional dysregulation

17 September 2017

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15

Lisa M Ellerby

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17 September 2017

Jessica E Young

1

1 reference

17 September 2017

Launce Gouw

2

1 reference

17 September 2017

Stephanie Propp

3

1 reference

17 September 2017

Bryce L Sopher

4

1 reference

17 September 2017

Jillian Taylor

5

1 reference

17 September 2017

Amy Lin

6

1 reference

17 September 2017

Evan Hermel

7

1 reference

17 September 2017

Anna Logvinova

8

1 reference

17 September 2017

Sylvia F Chen

9

1 reference

17 September 2017

Shiming Chen

10

1 reference

17 September 2017

Dale E Bredesen

11

1 reference

17 September 2017

Ray Truant

12

1 reference

17 September 2017

Louis J Ptacek

13

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17 September 2017

Albert R La Spada

14

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17 September 2017

language of work or name

English

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publication date

23 July 2007

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Journal of Biological Chemistry

17 September 2017

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17 September 2017

282

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17 September 2017

41

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17 September 2017

30150-30160

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Cloning of the SCA7 gene reveals a highly unstable CAG repeat expansion

17 September 2017

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M705265200

Ataxin-7 expression analysis in controls and spinocerebellar ataxia type 7 patients

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M705265200

Nuclear localization of the spinocerebellar ataxia type 7 protein, ataxin-7

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M705265200

A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M705265200

Expansion of an unstable trinucleotide CAG repeat in spinocerebellar ataxia type 1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M705265200

Cloning of the gene for spinocerebellar ataxia 2 reveals a locus with high sensitivity to expanded CAG/glutamine repeats

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M705265200

CAG expansions in a novel gene for Machado-Joseph disease at chromosome 14q32.1

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M705265200

Moderate expansion of a normally biallelic trinucleotide repeat in spinocerebellar ataxia type 2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M705265200

Dentatorubral and pallidoluysian atrophy expansion of an unstable CAG trinucleotide on chromosome 12p

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M705265200

Androgen receptor gene mutations in X-linked spinal and bulbar muscular atrophy

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M705265200

Histone deacetylase inhibitors arrest polyglutamine-dependent neurodegeneration in Drosophila

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M705265200

Cleavage of atrophin-1 at caspase site aspartic acid 109 modulates cytotoxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M705265200

Inhibition of calpain cleavage of huntingtin reduces toxicity: accumulation of calpain/caspase fragments in the nucleus

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M705265200

Cleavage of huntingtin by apopain, a proapoptotic cysteine protease, is modulated by the polyglutamine tract

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M705265200

Nuclear accumulation of truncated atrophin-1 fragments in a transgenic mouse model of DRPLA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M705265200

Aggregation of huntingtin in neuronal intranuclear inclusions and dystrophic neurites in brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M705265200

Caspase 3-cleaved N-terminal fragments of wild-type and mutant huntingtin are present in normal and Huntington's disease brains, associate with membranes, and undergo calpain-dependent proteolysis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M705265200

Specific caspase interactions and amplification are involved in selective neuronal vulnerability in Huntington's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M705265200

Subtype-specific enhancement of NMDA receptor currents by mutant huntingtin

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M705265200

Cell death triggered by polyglutamine-expanded huntingtin in a neuronal cell line is associated with degradation of CREB-binding protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M705265200

Altered proteasomal function due to the expression of polyglutamine-expanded truncated N-terminal huntingtin induces apoptosis by caspase activation through mitochondrial cytochrome c release

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M705265200

Interaction of Akt-phosphorylated ataxin-1 with 14-3-3 mediates neurodegeneration in spinocerebellar ataxia type 1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M705265200

Interference of Crx-dependent transcription by ataxin-7 involves interaction between the glutamine regions and requires the ataxin-7 carboxy-terminal region for nuclear localization

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M705265200

Ataxin-7 can export from the nucleus via a conserved exportin-dependent signal.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M705265200

Ataxin-7 is a subunit of GCN5 histone acetyltransferase-containing complexes

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M705265200

Glutamine-expanded ataxin-7 alters TFTC/STAGA recruitment and chromatin structure leading to photoreceptor dysfunction.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M705265200

Polyglutamine-expanded ataxin-7 inhibits STAGA histone acetyltransferase activity to produce retinal degeneration

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M705265200

SCA7 knockin mice model human SCA7 and reveal gradual accumulation of mutant ataxin-7 in neurons and abnormalities in short-term plasticity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M705265200

Polyglutamine-expanded ataxin-7 antagonizes CRX function and induces cone-rod dystrophy in a mouse model of SCA7

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M705265200

Electrophysiologic and phenotypic features of an autosomal cone-rod dystrophy caused by a novel CRX mutation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M705265200

Intranuclear neuronal inclusions: a common pathogenic mechanism for glutamine-repeat neurodegenerative diseases?

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M705265200

Huntington disease and the related disorder, dentatorubral-pallidoluysian atrophy (DRPLA).

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M705265200

Expanded polyglutamine in the Machado-Joseph disease protein induces cell death in vitro and in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M705265200

Inactivation of the mouse Huntington's disease gene homolog Hdh

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M705265200

Length of huntingtin and its polyglutamine tract influences localization and frequency of intracellular aggregates

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M705265200

Targeted disruption of the Huntington's disease gene results in embryonic lethality and behavioral and morphological changes in heterozygotes

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M705265200

Biology of A beta amyloid in Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M705265200

Increased apoptosis and early embryonic lethality in mice nullizygous for the Huntington's disease gene homologue

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M705265200

The influence of huntingtin protein size on nuclear localization and cellular toxicity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M705265200

Kennedy's disease: caspase cleavage of the androgen receptor is a crucial event in cytotoxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M705265200

Cleavage at the caspase-6 site is required for neuronal dysfunction and degeneration due to mutant huntingtin

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M705265200

Recruitment and activation of caspase-8 by the Huntingtin-interacting protein Hip-1 and a novel partner Hippi

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M705265200

SCA7 mouse models show selective stabilization of mutant ataxin-7 and similar cellular responses in different neuronal cell types

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M705265200

Nuclear localization of a non-caspase truncation product of atrophin-1, with an expanded polyglutamine repeat, increases cellular toxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M705265200

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M705265200

Inhibiting caspase cleavage of huntingtin reduces toxicity and aggregate formation in neuronal and nonneuronal cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M705265200

Cleavage of automodified poly(ADP-ribose) polymerase during apoptosis. Evidence for involvement of caspase-7.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M705265200

Structural basis for the activation of human procaspase-7

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M705265200

Huntingtin contains a highly conserved nuclear export signal

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M705265200

Discovery of an allosteric site in the caspases

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M705265200

Conserved Phosphoprotein Interaction Motif Is Functionally Interchangeable between Ataxin-7 and Arrestins†

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M705265200

21 January 2018

Identifiers

DOI

10.1074/JBC.M705265200

1 reference

17 September 2017

1 reference