(Q54614020)

1 June 2018

title

Protein phosphatase 1-dependent dephosphorylation of Akt is the prime signaling event in sphingosine-induced apoptosis in Jurkat cells. (English)

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author name string

Faisal Thayyullathil

1

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Shahanas Chathoth

2

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Allen Shahin

3

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Jaleel Kizhakkayil

4

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Abdulkader Hago

5

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Mahendra Patel

6

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Sehamuddin Galadari

7

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publication date

1 April 2011

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Journal of Cellular Biochemistry

published in

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volume

112

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issue

4

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page(s)

1138-1153

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Inhibition of the insulin receptor tyrosine kinase by sphingosine

cites work

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One of the protein phosphatase 1 isoenzymes in Drosophila is essential for mitosis.

21 January 2018

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Protein phosphatase 1alpha is a Ras-activated Bad phosphatase that regulates interleukin-2 deprivation-induced apoptosis

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Apoptosis in brain-specific autoimmune disease

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Regulation of cell death protease caspase-9 by phosphorylation

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Long chain ceramides activate protein phosphatase-1 and protein phosphatase-2A. Activation is stereospecific and regulated by phosphatidic acid

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Role of AKT kinase in sphingosine-induced apoptosis in human hepatoma cells

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Histone acetylation-independent effect of histone deacetylase inhibitors on Akt through the reshuffling of protein phosphatase 1 complexes

21 January 2018

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Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B

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Sphingosine in apoptosis signaling

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Sphingosine generation, cytochrome c release, and activation of caspase-7 in doxorubicin-induced apoptosis of MCF7 breast adenocarcinoma cells.

21 January 2018

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Akt phosphorylation and stabilization of X-linked inhibitor of apoptosis protein (XIAP).

21 January 2018

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Interleukin-3-induced phosphorylation of BAD through the protein kinase Akt

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Identification of PP1alpha as a caspase-9 regulator in IL-2 deprivation-induced apoptosis

21 January 2018

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Phosphorylation and inactivation of protein phosphatase 1 by cyclin-dependent kinases

21 January 2018

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Regulation of neuronal survival by the serine-threonine protein kinase Akt

21 January 2018

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Mechanisms and Functions of Cell Death

21 January 2018

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The protein kinase encoded by the Akt proto-oncogene is a target of the PDGF-activated phosphatidylinositol 3-kinase

21 January 2018

1 reference

Activation of caspase-3-like proteases in apoptosis induced by sphingosine and other long-chain bases in Hep3B hepatoma cells

21 January 2018

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Characterization of the interleukin-1beta-converting enzyme/ced-3-family protease, caspase-3/CPP32, in Hodgkin's disease: lack of caspase-3 expression in nodular lymphocyte predominance Hodgkin's disease

21 January 2018

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Induction of apoptosis and potentiation of ceramide-mediated cytotoxicity by sphingoid bases in human myeloid leukemia cells

21 January 2018

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Akt phosphorylates and negatively regulates apoptosis signal-regulating kinase 1

21 January 2018

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Phosphatidic acid is a potent and selective inhibitor of protein phosphatase 1 and an inhibitor of ceramide-mediated responses

21 January 2018

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Inhibitory phosphorylation of PP1alpha catalytic subunit during the G(1)/S transition

21 January 2018

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A novel immunosuppressive agent FTY720 induced Akt dephosphorylation in leukemia cells

21 January 2018

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Inactivation and dephosphorylation of protein kinase Balpha (PKBalpha) promoted by hyperosmotic stress

21 January 2018

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Sphingosine-1-phosphate as second messenger in cell proliferation induced by PDGF and FCS mitogens

21 January 2018

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Sphingosine-induced apoptosis in rhabdomyosarcoma cell lines is dependent on pre-mitochondrial Bax activation and post-mitochondrial caspases

21 January 2018

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Inhibition of PKB/Akt1 by C2-ceramide involves activation of ceramide-activated protein phosphatase in PC12 cells.

21 January 2018

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Ceramide inhibits protein kinase B/Akt by promoting dephosphorylation of serine 473.

21 January 2018

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Protein serine/threonine phosphatases--new avenues for cell regulation

21 January 2018

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Prevention of docosahexaenoic acid-induced cytotoxicity by phosphatidic acid in Jurkat leukemic cells: the role of protein phosphatase-1.

21 January 2018

1 reference

Yama/CPP32 beta, a mammalian homolog of CED-3, is a CrmA-inhibitable protease that cleaves the death substrate poly(ADP-ribose) polymerase

21 January 2018

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Rapid reactive oxygen species (ROS) generation induced by curcumin leads to caspase-dependent and -independent apoptosis in L929 cells.

21 January 2018

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Apoptosis in the pathogenesis and treatment of disease

21 January 2018

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Protein phosphatase 1alpha-mediated stimulation of apoptosis is associated with dephosphorylation of the retinoblastoma protein

21 January 2018

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Prognostic significance of activated Akt expression in pancreatic ductal adenocarcinoma

21 January 2018

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Activation of p38 mitogen-activated protein kinase is required for death receptor-independent caspase-8 activation and cell death in response to sphingosine

21 January 2018

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HER-2/neu induces p53 ubiquitination via Akt-mediated MDM2 phosphorylation

21 January 2018

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Lipid-Regulated Kinases: Some Common Themes at Last

21 January 2018

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21 January 2018

Identifiers

DOI

10.1002/JCB.23033

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1 June 2018

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