(Q54647670)

2 June 2018

title

p21 does not protect cancer cells from apoptosis induced by nongenotoxic p53 activation. (English)

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2 June 2018

author name string

M Xia

series ordinal

1

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2 June 2018

D Knezevic

series ordinal

2

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2 June 2018

L T Vassilev

series ordinal

3

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2 June 2018

language of work or name

English

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publication date

27 September 2010

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2 June 2018

published in

Oncogene

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2 June 2018

volume

30

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2 June 2018

issue

3

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2 June 2018

page(s)

346-355

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2 June 2018

https://scigraph.springernature.com/pub.10.1038/onc.2010.413

exact match

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cites work

p21 in cancer: intricate networks and multiple activities

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New wirings in the survivin networks

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Apoptosis inhibitory activity of cytoplasmic p21(Cip1/WAF1) in monocytic differentiation

21 January 2018

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p21-induced cycle arrest in G1 protects cells from apoptosis induced by UV-irradiation or RNA polymerase II blockage

21 January 2018

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Awakening guardian angels: drugging the p53 pathway

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Disruption of p53 in human cancer cells alters the responses to therapeutic agents

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Survivin is required for stable checkpoint activation in taxol-treated HeLa cells

21 January 2018

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Mitochondrial survivin inhibits apoptosis and promotes tumorigenesis.

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Compartmentalized phosphorylation of IAP by protein kinase A regulates cytoprotection

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Nuclear accumulation of p21Cip1 at the onset of mitosis: a role at the G2/M-phase transition

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WAF1, a potential mediator of p53 tumor suppression

21 January 2018

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MDM2-dependent downregulation of p21 and hnRNP K provides a switch between apoptosis and growth arrest induced by pharmacologically activated p53

21 January 2018

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HCT116 cells deficient in p21(Waf1) are hypersensitive to tyrosine kinase inhibitors and adriamycin through a mechanism unrelated to p21 and dependent on p53.

21 January 2018

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The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases

21 January 2018

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The p53 pathway: positive and negative feedback loops

21 January 2018

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Transcriptional repression of the anti-apoptotic survivin gene by wild type p53.

21 January 2018

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Sustained activation of the JNK cascade and rapamycin-induced apoptosis are suppressed by p53/p21(Cip1)

21 January 2018

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The multiple battles fought by anti-apoptotic p21.

21 January 2018

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A transcriptional activation function of p53 is dispensable for and inhibitory of its apoptotic function

21 January 2018

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Survivin is required for a sustained spindle checkpoint arrest in response to lack of tension

21 January 2018

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Cleavage of p21Cip1/Waf1 and p27Kip1 mediates apoptosis in endothelial cells through activation of Cdk2: role of a caspase cascade

21 January 2018

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Control of apoptosis and mitotic spindle checkpoint by survivin

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p21/CDKN1A mediates negative regulation of transcription by p53.

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Phosphorylation of p53 on key serines is dispensable for transcriptional activation and apoptosis

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Small-molecule MDM2 antagonists reveal aberrant p53 signaling in cancer: implications for therapy

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Live or let die: the cell's response to p53

21 January 2018

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Elevated MDM2 boosts the apoptotic activity of p53-MDM2 binding inhibitors by facilitating MDMX degradation

21 January 2018

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p21 is a universal inhibitor of cyclin kinases

21 January 2018

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Transcriptional Regulation of the p21(WAF1/CIP1)Gene

21 January 2018

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Myc suppression of the p21 Cip1 Cdk inhibitor influences the outcome of the p53 response to DNA damage

21 January 2018

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Mutated p21(WAF1/CIP1/SDI1) lacking CDK-inhibitory activity fails to prevent apoptosis in human colorectal carcinoma cells

21 January 2018

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p21 blocks irradiation-induced apoptosis downstream of mitochondria by inhibition of cyclin-dependent kinase-mediated caspase-9 activation

31 March 2020

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Resistance to Fas-mediated apoptosis: activation of caspase 3 is regulated by cell cycle regulator p21WAF1 and IAP gene family ILP

31 March 2020

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Caspase-mediated cleavage of p21Waf1/Cip1 converts cancer cells from growth arrest to undergoing apoptosis

31 March 2020

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31 March 2020

Identifiers

DOI

10.1038/ONC.2010.413

1 reference

2 June 2018

1 reference

2 June 2018