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NAD + biosynthesis, aging, and disease.
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Europe PubMed Central
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5795269
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29744033%20AND%20SRC:MED&resulttype=core&format=json
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26 March 2020
title
NAD + biosynthesis, aging, and disease
(English)
1 reference
stated in
Europe PubMed Central
PMCID
5795269
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29744033%20AND%20SRC:MED&resulttype=core&format=json
retrieved
26 March 2020
author
Sean Johnson
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1
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Europe PubMed Central
PMCID
5795269
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29744033%20AND%20SRC:MED&resulttype=core&format=json
retrieved
26 March 2020
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Shin-Ichiro Imai
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2
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Europe PubMed Central
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5795269
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29744033%20AND%20SRC:MED&resulttype=core&format=json
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26 March 2020
publication date
1 February 2018
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Europe PubMed Central
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5795269
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retrieved
26 March 2020
published in
F1000Research
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Europe PubMed Central
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5795269
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retrieved
26 March 2020
volume
7
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Europe PubMed Central
PMCID
5795269
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29744033%20AND%20SRC:MED&resulttype=core&format=json
retrieved
26 March 2020
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132
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Europe PubMed Central
PMCID
5795269
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29744033%20AND%20SRC:MED&resulttype=core&format=json
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26 March 2020
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1 February 2018
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NAMPT-Mediated NAD(+) Biosynthesis Is Essential for Vision In Mice
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CD38 Dictates Age-Related NAD Decline and Mitochondrial Dysfunction through an SIRT3-Dependent Mechanism.
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Nicotinamide mononucleotide protects against β-amyloid oligomer-induced cognitive impairment and neuronal death
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NAD⁺ repletion improves mitochondrial and stem cell function and enhances life span in mice
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Genomic integrity and the ageing brain
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Physiological and pathophysiological roles of NAMPT and NAD metabolism
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Effect of nicotinamide mononucleotide on brain mitochondrial respiratory deficits in an Alzheimer's disease-relevant murine model
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NAD+ and sirtuins in aging and disease
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SIRT6 regulates TNF-α secretion through hydrolysis of long-chain fatty acyl lysine
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Nicotinamide riboside restores cognition through an upregulation of proliferator-activated receptor-γ coactivator 1α regulated β-secretase 1 degradation and mitochondrial gene expression in Alzheimer's mouse models
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Flavonoid apigenin is an inhibitor of the NAD+ ase CD38: implications for cellular NAD+ metabolism, protein acetylation, and treatment of metabolic syndrome
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The sirtuin SIRT6 regulates lifespan in male mice
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SIRT1 activates MAO-A in the brain to mediate anxiety and exploratory drive
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Nicotinamide mononucleotide, a key NAD(+) intermediate, treats the pathophysiology of diet- and age-induced diabetes in mice
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16 June 2018
Age related changes in NAD+ metabolism oxidative stress and Sirt1 activity in wistar rats
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16 June 2018
PARP-1 inhibition increases mitochondrial metabolism through SIRT1 activation
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Reduced mitochondrial function in obesity-associated fatty liver: SIRT3 takes on the fat.
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16 June 2018
Fatty liver is associated with reduced SIRT3 activity and mitochondrial protein hyperacetylation
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16 June 2018
Sirtuin regulation of mitochondria: energy production, apoptosis, and signaling
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16 June 2018
Neuroinflammatory processes in Alzheimer's disease
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16 June 2018
Sirt1 activation protects the mouse renal medulla from oxidative injury
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16 June 2018
SIRT3 regulates mitochondrial fatty-acid oxidation by reversible enzyme deacetylation
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16 June 2018
Mammalian sirtuins: biological insights and disease relevance
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16 June 2018
Downregulation of the longevity-associated protein sirtuin 1 in insulin resistance and metabolic syndrome: potential biochemical mechanisms
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16 June 2018
CD38 as a regulator of cellular NAD: a novel potential pharmacological target for metabolic conditions
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16 June 2018
Sirtuin 1 reduction parallels the accumulation of tau in Alzheimer disease
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16 June 2018
Sirt1 protects against high-fat diet-induced metabolic damage
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16 June 2018
Nicotinic acid, nicotinamide, and nicotinamide riboside: a molecular evaluation of NAD+ precursor vitamins in human nutrition
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16 June 2018
Age-associated loss of Sirt1-mediated enhancement of glucose-stimulated insulin secretion in beta cell-specific Sirt1-overexpressing (BESTO) mice
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16 June 2018
Nampt/PBEF/Visfatin regulates insulin secretion in beta cells as a systemic NAD biosynthetic enzyme
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16 June 2018
Sirt1 modulates premature senescence-like phenotype in human endothelial cells
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16 June 2018
Nucleocytoplasmic shuttling of the NAD+-dependent histone deacetylase SIRT1
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16 June 2018
NAD+ metabolism in health and disease
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16 June 2018
SIRT4 inhibits glutamate dehydrogenase and opposes the effects of calorie restriction in pancreatic beta cells
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16 June 2018
Structure of Nampt/PBEF/visfatin, a mammalian NAD+ biosynthetic enzyme.
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16 June 2018
Neuronal SIRT1 activation as a novel mechanism underlying the prevention of Alzheimer disease amyloid neuropathology by calorie restriction
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16 June 2018
SirT2 is a histone deacetylase with preference for histone H4 Lys 16 during mitosis
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16 June 2018
Mammalian Sir2 homolog SIRT7 is an activator of RNA polymerase I transcription
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16 June 2018
Genomic instability and aging-like phenotype in the absence of mammalian SIRT6
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16 June 2018
Sirt1 regulates insulin secretion by repressing UCP2 in pancreatic beta cells
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16 June 2018
Mouse Sir2 homolog SIRT6 is a nuclear ADP-ribosyltransferase
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16 June 2018
Autocrine and paracrine calcium signaling by the CD38/NAD+/cyclic ADP-ribose system
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16 June 2018
The NAD biosynthesis pathway mediated by nicotinamide phosphoribosyltransferase regulates Sir2 activity in mammalian cells
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16 June 2018
Discoveries of nicotinamide riboside as a nutrient and conserved NRK genes establish a Preiss-Handler independent route to NAD+ in fungi and humans
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16 June 2018
Nicotinamide mononucleotide activation of a new DNA-dependent polyadenylic acid synthesizing nuclear enzyme
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16 June 2018
Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase
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16 June 2018
Poly(ADP-ribose) polymerase activity in mononuclear leukocytes of 13 mammalian species correlates with species-specific life span
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16 June 2018
NAD+ Intermediates: The Biology and Therapeutic Potential of NMN and NR.
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The SARM1 Toll/Interleukin-1 Receptor Domain Possesses Intrinsic NAD+ Cleavage Activity that Promotes Pathological Axonal Degeneration.
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5795269
retrieved
13 August 2018
Nicotinamide mononucleotide inhibits JNK activation to reverse Alzheimer disease.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5795269
retrieved
13 August 2018
Long-Term Administration of Nicotinamide Mononucleotide Mitigates Age-Associated Physiological Decline in Mice
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5795269
retrieved
13 August 2018
Neophobia, NQO1 and SIRT1 as premorbid and prodromal indicators of AD in 3xTg-AD mice.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5795269
retrieved
13 August 2018
Physical exercise improves synaptic dysfunction and recovers the loss of survival factors in 3xTg-AD mouse brain.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5795269
retrieved
13 August 2018
Distinct patterns of sirtuin expression during progression of Alzheimer's disease.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5795269
retrieved
13 August 2018
The many faces of sirtuins: Coupling of NAD metabolism, sirtuins and lifespan
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5795269
retrieved
13 August 2018
Epigenetic regulation of BACE1 in Alzheimer's disease patients and in transgenic mice.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5795269
retrieved
13 August 2018
Inflammatory and age-related pathologies in mice with ectopic expression of human PARP-1.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5795269
retrieved
13 August 2018
Protective role of SIRT1 in diabetic vascular dysfunction
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5795269
retrieved
13 August 2018
Cilostazol inhibits oxidative stress-induced premature senescence via upregulation of Sirt1 in human endothelial cells
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5795269
retrieved
13 August 2018
The enzyme CD38 (a NAD glycohydrolase, EC 3.2.2.5) is necessary for the development of diet-induced obesity.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5795269
retrieved
13 August 2018
Regulation of intracellular levels of NAD: a novel role for CD38.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5795269
retrieved
13 August 2018
Increased dosage of mammalian Sir2 in pancreatic beta cells enhances glucose-stimulated insulin secretion in mice
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5795269
retrieved
13 August 2018
The expression of SIRT1 in nonalcoholic fatty liver disease induced by high-fat diet in rats
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/29744033
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Activating SIRT1: a new strategy to prevent atherosclerosis?
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/29744033
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
SIRT1: a novel target to prevent atherosclerosis
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/29744033
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Direct evidence of sirtuin downregulation in the liver of non-alcoholic fatty liver disease patients
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/29744033
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
The Sirt1 activator SRT1720 attenuates angiotensin II-induced atherosclerosis in apoE⁻/⁻ mice through inhibiting vascular inflammatory response
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/29744033
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Identifiers
DOI
10.12688/F1000RESEARCH.12120.1
1 reference
stated in
Europe PubMed Central
PMCID
5795269
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29744033%20AND%20SRC:MED&resulttype=core&format=json
retrieved
26 March 2020
PMCID
5795269
1 reference
stated in
Europe PubMed Central
PMCID
5795269
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29744033%20AND%20SRC:MED&resulttype=core&format=json
retrieved
26 March 2020
PubMed ID
29744033
1 reference
stated in
Europe PubMed Central
PMCID
5795269
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29744033%20AND%20SRC:MED&resulttype=core&format=json
retrieved
26 March 2020
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