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BRD4 inhibitors block telomere elongation

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BRD4 inhibitors block telomere elongation (English)

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Carla Connelly

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Carol Greider

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Carol W. Greider

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Steven Wang

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Alexandra Pike

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Stella Lee

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publication date

27 February 2017

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bioRxiv

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cites work

Haploinsufficiency of telomerase reverse transcriptase leads to anticipation in autosomal dominant dyskeratosis congenita

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1101/112169

TERT promoter mutations occur frequently in gliomas and a subset of tumors derived from cells with low rates of self-renewal

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11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1101/112169

Targeting cancer with small molecule kinase inhibitors

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11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1101/112169

The short and long telomere syndromes: paired paradigms for molecular medicine

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11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1101/112169

Telomerase mutations in families with idiopathic pulmonary fibrosis

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11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1101/112169

Telomeres shorten during ageing of human fibroblasts

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11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1101/112169

TEL1, a gene involved in controlling telomere length in S. cerevisiae, is homologous to the human ataxia telangiectasia gene.

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11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1101/112169

Telomerase and cancer therapeutics

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11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1101/112169

Regulation of telomerase by telomeric proteins

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11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1101/112169

Bromodomain 4: a cellular Swiss army knife

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11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1101/112169

BRD4 is an atypical kinase that phosphorylates serine2 of the RNA polymerase II carboxy-terminal domain

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11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1101/112169

Tankyrase, a poly(ADP-ribose) polymerase at human telomeres

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11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1101/112169

MEC3, MEC1, and DDC2 are essential components of a telomere checkpoint pathway required for cell cycle arrest during senescence in Saccharomyces cerevisiae

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11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1101/112169

Telomerase activation. One step on the road to cancer?

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11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1101/112169

The TEL patch of telomere protein TPP1 mediates telomerase recruitment and processivity

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11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1101/112169

DNA degradation at unprotected telomeres in yeast is regulated by the CDK1 (Cdc28/Clb) cell-cycle kinase

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11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1101/112169

Targeting MYC dependence in cancer by inhibiting BET bromodomains

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11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1101/112169

DNA-damage response and repair activities at uncapped telomeres depend on RNF8

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11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1101/112169

Mechanism of human telomerase inhibition by BIBR1532, a synthetic, non-nucleosidic drug candidate.

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11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1101/112169

ATM Kinase Is Required for Telomere Elongation in Mouse and Human Cells

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11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1101/112169

The POT1-TPP1 telomere complex is a telomerase processivity factor

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11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1101/112169

BRD4 bromodomain gene rearrangement in aggressive carcinoma with translocation t(15;19)

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11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1101/112169

BRD4 is a novel therapeutic target for liver fibrosis

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11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1101/112169

ATM and ATR Signaling Regulate the Recruitment of Human Telomerase to Telomeres

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11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1101/112169

BET bromodomain inhibition as a therapeutic strategy to target c-Myc

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11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1101/112169

BRD4 is a histone acetyltransferase that evicts nucleosomes from chromatin

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11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1101/112169

TERT promoter mutations in familial and sporadic melanoma

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11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1101/112169

Regulation of telomere elongation by the cyclin-dependent kinase CDK1.

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11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1101/112169

MAGeCK enables robust identification of essential genes from genome-scale CRISPR/Cas9 knockout screens

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11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1101/112169

The telomere syndromes

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11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1101/112169

High-throughput RNAi screening reveals novel regulators of telomerase

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11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1101/112169

Telomerase, Cell Immortality, and Cancer

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11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1101/112169

Telomeres, telomerase and senescence

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11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1101/112169

POT1 mutations cause telomere dysfunction in chronic lymphocytic leukemia

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11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1101/112169

The double bromodomain-containing chromatin adaptor Brd4 and transcriptional regulation

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1101/112169

Bromodomain inhibitor OTX015 in patients with acute leukaemia: a dose-escalation, phase 1 study

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1101/112169

Imetelstat (GRN163L)--telomerase-based cancer therapy

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1101/112169

Suppression of inflammation by a synthetic histone mimic

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11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1101/112169

Selective cytotoxicity and telomere damage in leukemia cells using the telomerase inhibitor BIBR1532.

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1101/112169

Telomeres and age-related disease: how telomere biology informs clinical paradigms

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11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1101/112169

How shelterin protects mammalian telomeres

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11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1101/112169

Assessment of Brd4 inhibition in idiopathic pulmonary fibrosis lung fibroblasts and in vivo models of lung fibrosis

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1101/112169

Selective inhibition of BET bromodomains

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1101/112169

Flow cytometry and FISH to measure the average length of telomeres (flow FISH).

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1101/112169

RNAi screen identifies Brd4 as a therapeutic target in acute myeloid leukaemia

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1101/112169

Identification of a specific telomere terminal transferase activity in Tetrahymena extracts

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1101/112169

Gene bookmarking accelerates the kinetics of post-mitotic transcriptional re-activation

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1101/112169

A highly selective telomerase inhibitor limiting human cancer cell proliferation

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1101/112169

Inhibition of bromodomain and extra-terminal proteins (BET) as a potential therapeutic approach in haematological malignancies: emerging preclinical and clinical evidence

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1101/112169

Fast gapped-read alignment with Bowtie 2

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1101/112169

Brd4 marks select genes on mitotic chromatin and directs postmitotic transcription

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1101/112169

Telomerase activity in human breast tumors

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1101/112169

Telomere length homeostasis requires that telomerase levels are limiting

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1101/112169

Highly recurrent TERT promoter mutations in human melanoma

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1101/112169

Control of human telomere length by TRF1 and TRF2

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1101/112169

Short telomeres induce a DNA damage response in Saccharomyces cerevisiae

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1101/112169

Treating Myeloproliferation--On Target or Off?

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1101/112169

A randomized phase II study of the telomerase inhibitor imetelstat as maintenance therapy for advanced non-small-cell lung cancer

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1101/112169

RNAi screen for telomerase reverse transcriptase transcriptional regulators identifies HIF1alpha as critical for telomerase function in murine embryonic stem cells

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1101/112169

Bromodomain inhibitor OTX015 in patients with lymphoma or multiple myeloma: a dose-escalation, open-label, pharmacokinetic, phase 1 study

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1101/112169

Understanding TERT Promoter Mutations: A Common Path to Immortality.

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1101/112169

A DNA damage checkpoint response in telomere-initiated senescence

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1101/112169

A yeast chemical genetic screen identifies inhibitors of human telomerase

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1101/112169

An Overview on Small Molecule Inhibitors of BRD4.

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1101/112169

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10.1101/112169

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(Q56507869)

BRD4 inhibitors block telomere elongation

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