(Q56891850)

2

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John L Macomber

3

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Irina P Krapf

4

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Andy Chen

5

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Joseph C Sheffer

6

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Ashley Berkebile

7

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Robert A Horlick

8

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Steven Neben

9

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David J King

10

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Peter M Bowers

Protein Engineering Design and Selection

11

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language of work or name

English

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publication date

February 2013

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published in

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volume

26

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issue

2

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page(s)

151-64

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cites work

Identification of residues that stabilize the single-chain Fv of monoclonal antibodies B3.

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https://api.crossref.org/works/10.1093%2FPROTEIN%2FGZS090

Coupling mammalian cell surface display with somatic hypermutation for the discovery and maturation of human antibodies

21 January 2018

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Engineering antibodies for imaging and therapy

21 January 2018

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Design of therapeutic proteins with enhanced stability.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FPROTEIN%2FGZS090

Affinity enhancement of an in vivo matured therapeutic antibody using structure-based computational design

21 January 2018

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https://api.crossref.org/works/10.1093%2FPROTEIN%2FGZS090

Antibody production, design and use for biosensor-based applications

21 January 2018

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https://api.crossref.org/works/10.1093%2FPROTEIN%2FGZS090

De novo protein design: fully automated sequence selection

21 January 2018

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https://api.crossref.org/works/10.1093%2FPROTEIN%2FGZS090

A large scale test of computational protein design: folding and stability of nine completely redesigned globular proteins

21 January 2018

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https://api.crossref.org/works/10.1093%2FPROTEIN%2FGZS090

High-resolution structural and thermodynamic analysis of extreme stabilization of human procarboxypeptidase by computational protein design

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FPROTEIN%2FGZS090

Optimization of the antibody C(H)3 domain by residue frequency analysis of IgG sequences

21 January 2018

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https://api.crossref.org/works/10.1093%2FPROTEIN%2FGZS090

An intermediate pH unfolding transition abrogates the ability of IgE to interact with its high affinity receptor FcepsilonRIalpha.

21 January 2018

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https://api.crossref.org/works/10.1093%2FPROTEIN%2FGZS090

Dominant forces in protein folding

21 January 2018

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https://api.crossref.org/works/10.1093%2FPROTEIN%2FGZS090

Disulfide by Design™: a computational method for the rational design of disulfide bonds in proteins

21 January 2018

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https://api.crossref.org/works/10.1093%2FPROTEIN%2FGZS090

Bayesian statistical analysis of protein side-chain rotamer preferences

21 January 2018

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https://api.crossref.org/works/10.1093%2FPROTEIN%2FGZS090

Structure-based improvement of the biophysical properties of immunoglobulin VH domains with a generalizable approach

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FPROTEIN%2FGZS090

Biophysical properties of human antibody variable domains

21 January 2018

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Stability improvement of antibodies for extracellular and intracellular applications: CDR grafting to stable frameworks and structure-based framework engineering

21 January 2018

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https://api.crossref.org/works/10.1093%2FPROTEIN%2FGZS090

Improving the species cross-reactivity of an antibody using computational design

21 January 2018

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Contribution of the intramolecular disulfide bridge to the folding stability of REIv, the variable domain of a human immunoglobulin kappa light chain.

21 January 2018

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https://api.crossref.org/works/10.1093%2FPROTEIN%2FGZS090

A broad range of Fab stabilities within a host of therapeutic IgGs.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FPROTEIN%2FGZS090

A test of the "jigsaw puzzle" model for protein folding by multiple methionine substitutions within the core of T4 lysozyme

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FPROTEIN%2FGZS090

Precise determination of the diversity of a combinatorial antibody library gives insight into the human immunoglobulin repertoire

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FPROTEIN%2FGZS090

Engineered human antibody constant domains with increased stability

21 January 2018

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https://api.crossref.org/works/10.1093%2FPROTEIN%2FGZS090

The Role of the Intrachain Disulfide Bond in the Conformation and Stability of the Constant Fragment of the Immunoglobulin Light Chain1

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FPROTEIN%2FGZS090

The influence of the framework core residues on the biophysical properties of immunoglobulin heavy chain variable domains

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FPROTEIN%2FGZS090

Selecting and screening recombinant antibody libraries

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FPROTEIN%2FGZS090

Replacing the complementarity-determining regions in a human antibody with those from a mouse

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FPROTEIN%2FGZS090

Structural understanding of stabilization patterns in engineered bispecific Ig-like antibody molecules

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FPROTEIN%2FGZS090

Improving in vivo folding and stability of a single-chain Fv antibody fragment by loop grafting

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FPROTEIN%2FGZS090

Selection for improved protein stability by phage display.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FPROTEIN%2FGZS090

Fully synthetic human combinatorial antibody libraries (HuCAL) based on modular consensus frameworks and CDRs randomized with trinucleotides

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FPROTEIN%2FGZS090

Computational thermostabilization of an enzyme

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FPROTEIN%2FGZS090

Native protein sequences are close to optimal for their structures

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FPROTEIN%2FGZS090

Design of a Novel Globular Protein Fold with Atomic-Level Accuracy

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FPROTEIN%2FGZS090

The nature of antibody heavy chain residue H6 strongly influences the stability of a VH domain lacking the disulfide bridge

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FPROTEIN%2FGZS090

Expression of an antibody fragment at high levels in the bacterial cytoplasm

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FPROTEIN%2FGZS090

Stabilization of phage T4 lysozyme by engineered disulfide bonds

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FPROTEIN%2FGZS090

Improving the stability of an antibody variable fragment by a combination of knowledge-based approaches: validation and mechanisms.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FPROTEIN%2FGZS090

Control of translational repression by protein-protein interactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FPROTEIN%2FGZS090

The effect of additional disulfide bonds on the stability and folding of ribonuclease A.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FPROTEIN%2FGZS090

Antibody scFv fragments without disulfide bonds made by molecular evolution

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FPROTEIN%2FGZS090

A humanized antibody that binds to the interleukin 2 receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FPROTEIN%2FGZS090

Engineering interchain disulfide bonds into conserved framework regions of Fv fragments: improved biochemical characteristics of recombinant immunotoxins containing disulfide-stabilized Fv.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FPROTEIN%2FGZS090

Domain interactions in the Fab fragment: a comparative evaluation of the single-chain Fv and Fab format engineered with variable domains of different stability

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FPROTEIN%2FGZS090

Single-domain antibodies as building blocks for novel therapeutics

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FPROTEIN%2FGZS090

Transfer of engineered biophysical properties between different antibody formats and expression systems

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FPROTEIN%2FGZS090

Backrub-like backbone simulation recapitulates natural protein conformational variability and improves mutant side-chain prediction

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FPROTEIN%2FGZS090

Consensus-based engineering of protein stability: from intrabodies to thermostable enzymes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FPROTEIN%2FGZS090

Sequence statistics reliably predict stabilizing mutations in a protein domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FPROTEIN%2FGZS090

The role of thiols and disulfides on protein stability.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FPROTEIN%2FGZS090

Human IgG Fc receptor heterogeneity: molecular aspects and clinical implications

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FPROTEIN%2FGZS090

The thermal stability of immunoglobulin: unfolding and aggregation of a multi-domain protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FPROTEIN%2FGZS090

Conserved amino acid networks involved in antibody variable domain interactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FPROTEIN%2FGZS090

Different Equilibrium Stability Behavior of ScFv Fragments: Identification, Classification, and Improvement by Protein Engineering†

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FPROTEIN%2FGZS090

Stability engineering of antibody single-chain Fv fragments

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FPROTEIN%2FGZS090

Correlation betweenin VitroStability andin VivoPerformance of Anti-GCN4 Intrabodies as Cytoplasmic Inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FPROTEIN%2FGZS090

Thermal stabilization of a single-chain Fv antibody fragment by introduction of a disulphide bond.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FPROTEIN%2FGZS090

Disulfide bond formation and its impact on the biological activity and stability of recombinant therapeutic proteins produced by Escherichia coli expression system

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FPROTEIN%2FGZS090