(Q56977996)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19236225%20AND%20SRC:MED&resulttype=core&format=json

22 January 2020

review article

1 reference

title

Computational toxicology: an overview of the sources of data and of modelling methods (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19236225%20AND%20SRC:MED&resulttype=core&format=json

22 January 2020

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19236225%20AND%20SRC:MED&resulttype=core&format=json

John Blayney Owen Mitchell

22 January 2020

series ordinal

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19236225%20AND%20SRC:MED&resulttype=core&format=json

22 January 2020

author name string

Donatas Zmuidinavicius

series ordinal

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19236225%20AND%20SRC:MED&resulttype=core&format=json

22 January 2020

N J Maximilan Macaluso

series ordinal

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19236225%20AND%20SRC:MED&resulttype=core&format=json

22 January 2020

language of work or name

English

0 references

publication date

1 January 2009

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19236225%20AND%20SRC:MED&resulttype=core&format=json

Expert Opinion on Drug Metabolism & Toxicology

22 January 2020

published in

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19236225%20AND%20SRC:MED&resulttype=core&format=json

22 January 2020

volume

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19236225%20AND%20SRC:MED&resulttype=core&format=json

22 January 2020

issue

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19236225%20AND%20SRC:MED&resulttype=core&format=json

22 January 2020

page(s)

1-14

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19236225%20AND%20SRC:MED&resulttype=core&format=json

Ushering in the new toxicology: toxicogenomics and the public interest

22 January 2020

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Future of toxicology--predictive toxicology: An expanded view of "chemical toxicity".

21 January 2018

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Modeling promiscuity based on in vitro safety pharmacology profiling data

21 January 2018

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Use of toxicological information in drug design.

21 January 2018

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The emerging importance of predictive ADME simulation in drug discovery

21 January 2018

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Genomic and genetic biomarkers of toxicity

21 January 2018

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Predictive value of in vitro safety studies

21 January 2018

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Toxicogenomics and systems toxicology: aims and prospects

21 January 2018

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Toxicogenomics: a new revolution in drug safety

21 January 2018

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Toxicological and clinical computational analysis and the US FDA/CDER.

21 January 2018

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Toxicity data informatics: supporting a new paradigm for toxicity prediction

21 January 2018

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Technological advances in high-throughput screening

21 January 2018

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Integrating high-content screening and ligand-target prediction to identify mechanism of action

21 January 2018

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The public road to high-quality curated biological pathways

21 January 2018

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Network biology: understanding the cell's functional organization

21 January 2018

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'Systems toxicology' approach identifies coordinated metabolic responses to copper in a terrestrial non-model invertebrate, the earthworm Lumbricus rubellus

21 January 2018

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QT interval prolongation: and the beat goes on.

21 January 2018

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Pharmaceutical profiling in drug discovery.

21 January 2018

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Integration of virtual and high-throughput screening

21 January 2018

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Systems cell biology based on high-content screening

21 January 2018

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Human hepatocytes: isolation, cryopreservation and applications in drug development

21 January 2018

1 reference

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Neurotoxicity assessment using zebrafish

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250802660467

Analysis of cell death inducing compounds

21 January 2018

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Strategies and testing methods for identifying mutagenic risks

21 January 2018

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Methods of in vitro toxicology

21 January 2018

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Small-molecule screening: advances in microarraying and cell-imaging technologies

21 January 2018

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How can toxicogenomics inform risk assessment?

21 January 2018

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Toxicogenomics in predictive toxicology in drug development

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250802660467

Database development in toxicogenomics: issues and efforts

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250802660467

Systems toxicology: applications of toxicogenomics, transcriptomics, proteomics and metabolomics in toxicology

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250802660467

Predicting interactions from mechanistic information: can omic data validate theories?

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250802660467

Prediction of clinical drug efficacy by classification of drug-induced genomic expression profiles in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250802660467

Progress in applying genomics in drug development

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250802660467

ArrayTrack--supporting toxicogenomic research at the U.S. Food and Drug Administration National Center for Toxicological Research

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250802660467

Development of public toxicogenomics software for microarray data management and analysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250802660467

Simultaneous clustering of gene expression data with clinical chemistry and pathological evaluations reveals phenotypic prototypes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250802660467

Analysis of system structure-function relationships

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250802660467

CEBS--Chemical Effects in Biological Systems: a public data repository integrating study design and toxicity data with microarray and proteomics data.

21 January 2018

1 reference

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Understanding genetic toxicity through data mining: the process of building knowledge by integrating multiple genetic toxicity databases

21 January 2018

1 reference

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Distributed structure-searchable toxicity (DSSTox) public database network: a proposal

21 January 2018

1 reference

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Data merging for integrated microarray and proteomic analysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250802660467

Toxicity-indicating structural patterns

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250802660467

Use of computer-assisted prediction of toxic effects of chemical substances

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250802660467

The expanding role of predictive toxicology: an update on the (Q)SAR models for mutagens and carcinogens

21 January 2018

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Computational toxicology in drug development

21 January 2018

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Progress in QSAR toxicity screening of pharmaceutical impurities and other FDA regulated products

21 January 2018

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A QSAR for the mutagenic potencies of twelve 2-amino-trimethylimidazopyridine isomers: structural, quantum chemical, and hydropathic factors

21 January 2018

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Combined Use of MC4PC, MDL-QSAR, BioEpisteme, Leadscope PDM, and Derek for Windows Software to Achieve High-Performance, High-Confidence, Mode of Action-Based Predictions of Chemical Carcinogenesis in Rodents.

21 January 2018

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Substructure-based support vector machine classifiers for prediction of adverse effects in diverse classes of drugs

21 January 2018

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Keynote review: in vitro safety pharmacology profiling: an essential tool for successful drug development

21 January 2018

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Predicting the toxic potential of drugs and chemicals in silico: a model for the peroxisome proliferator-activated receptor gamma (PPAR gamma).

21 January 2018

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Peroxisome proliferator-activated receptors: nuclear control of metabolism

21 January 2018

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The toxicology of ligands for peroxisome proliferator-activated receptors (PPAR).

21 January 2018

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Toxicological relationships between proteins obtained from protein target predictions of large toxicity databases

21 January 2018

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Analysis of pharmacology data and the prediction of adverse drug reactions and off-target effects from chemical structure

21 January 2018

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Drug interactions in cancer therapy

21 January 2018

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Can we rationally design promiscuous drugs?

21 January 2018

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Selective optimization of side activities: another way for drug discovery

21 January 2018

1 reference

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Bridging chemical and biological space: "target fishing" using 2D and 3D molecular descriptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250802660467

PASS: prediction of activity spectra for biologically active substances

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250802660467

SuperTarget and Matador: resources for exploring drug-target relationships

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250802660467

STITCH: interaction networks of chemicals and proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250802660467

PDTD: a web-accessible protein database for drug target identification

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250802660467

DrugBank: a knowledgebase for drugs, drug actions and drug targets

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250802660467

Drug Adverse Reaction Target Database (DART) : proteins related to adverse drug reactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250802660467

Enrichment of high-throughput screening data with increasing levels of noise using support vector machines, recursive partitioning, and laplacian-modified naive bayesian classifiers

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250802660467

Using extended-connectivity fingerprints with Laplacian-modified Bayesian analysis in high-throughput screening follow-up

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250802660467

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250802660467

Shape signatures: a new approach to computer-aided ligand- and receptor-based drug design

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250802660467

Shape signatures: new descriptors for predicting cardiotoxicity in silico

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250802660467

Relating protein pharmacology by ligand chemistry

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250802660467

How many drug targets are there?

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250802660467

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250802660467

I want a new drug: G-protein-coupled receptors in drug development

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250802660467

On the applicability of GPCR homology models to computer-aided drug discovery: a comparison between in silico and crystal structures of the beta2-adrenergic receptor.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250802660467

Ligand-protein inverse docking and its potential use in the computer search of protein targets of a small molecule

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250802660467

Fold independent structural comparisons of protein-ligand binding sites for exploring functional relationships

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250802660467

A searchable database for comparing protein-ligand binding sites for the analysis of structure-function relationships.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250802660467

Towards a structural classification of phosphate binding sites in protein-nucleotide complexes: an automated all-against-all structural comparison using geometric matching

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250802660467

Prediction of potential drug targets based on simple sequence properties

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250802660467

Chemogenomic data analysis: prediction of small-molecule targets and the advent of biological fingerprint

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250802660467

Development of proteo-chemometrics: a novel technology for the analysis of drug-receptor interactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250802660467

Generalized modeling of enzyme-ligand interactions using proteochemometrics and local protein substructures

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250802660467

Rough set-based proteochemometrics modeling of G-protein-coupled receptor-ligand interactions.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250802660467

Computer systems for the prediction of toxicity: an update

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250802660467

Comparison of MC4PC and MDL-QSAR rodent carcinogenicity predictions and the enhancement of predictive performance by combining QSAR models.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250802660467

In silico tools for sharing data and knowledge on toxicity and metabolism: derek for windows, meteor, and vitic

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250802660467

The E-state as the basis for molecular structure space definition and structure similarity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250802660467

10.1517/17425250802660467

21 January 2018

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19236225%20AND%20SRC:MED&resulttype=core&format=json

22 January 2020

1 reference