(Q57080797)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26660228%20AND%20SRC:MED&resulttype=core&format=json

2 March 2020

title

Differential Anti-inflammatory Activity of HDAC Inhibitors in Human Macrophages and Rat Arthritis (English)

1 reference

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2 March 2020

0 references

1

1 reference

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2 March 2020

Abishek Iyer

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26660228%20AND%20SRC:MED&resulttype=core&format=json

2 March 2020

Robert C. Reid

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26660228%20AND%20SRC:MED&resulttype=core&format=json

2 March 2020

Matthew J. Sweet

8

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26660228%20AND%20SRC:MED&resulttype=core&format=json

2 March 2020

author name string

Thomas J Fairlie

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26660228%20AND%20SRC:MED&resulttype=core&format=json

2 March 2020

Adam Cotterell

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26660228%20AND%20SRC:MED&resulttype=core&format=json

2 March 2020

Praveer Gupta

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26660228%20AND%20SRC:MED&resulttype=core&format=json

2 March 2020

David A Vesey

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26660228%20AND%20SRC:MED&resulttype=core&format=json

2 March 2020

David P Fairlie

9

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26660228%20AND%20SRC:MED&resulttype=core&format=json

2 March 2020

language of work or name

English

0 references

publication date

10 December 2015

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26660228%20AND%20SRC:MED&resulttype=core&format=json

Journal of Pharmacology and Experimental Therapeutics

2 March 2020

published in

1 reference

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2 March 2020

volume

356

1 reference

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2 March 2020

issue

2

1 reference

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2 March 2020

page(s)

387-396

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26660228%20AND%20SRC:MED&resulttype=core&format=json

HDAC inhibitors block innate immunity

2 March 2020

cites work

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Histone deacetylase inhibitors decrease Toll-like receptor-mediated activation of proinflammatory gene expression by impairing transcription factor recruitment

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Inhibiting histone deacetylase 1 suppresses both inflammation and bone loss in arthritis

21 January 2018

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Lysine acetylation targets protein complexes and co-regulates major cellular functions

21 January 2018

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A therapeutic strategy uses histone deacetylase inhibitors to modulate the expression of genes involved in the pathogenesis of rheumatoid arthritis

21 January 2018

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Targeting monocytes/macrophages in the treatment of rheumatoid arthritis.

21 January 2018

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Small molecule inhibitors of histone acetyltransferases and deacetylases are potential drugs for inflammatory diseases.

21 January 2018

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The binding modes and binding affinities of artemisinin derivatives with Plasmodium falciparum Ca2+-ATPase (PfATP6).

21 January 2018

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HDACs and their inhibitors in immunology: teaching anticancer drugs new tricks

21 January 2018

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Histone deacetylases and their inhibitors in cancer, neurological diseases and immune disorders

21 January 2018

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Pharmacokinetics, safety and inducible cytokine responses during a phase 1 trial of the oral histone deacetylase inhibitor ITF2357 (givinostat).

21 January 2018

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Targeting histone deacetylase activity in rheumatoid arthritis and asthma as prototypes of inflammatory disease: should we keep our HATs on?

21 January 2018

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Towards isozyme-selective HDAC inhibitors for interrogating disease.

21 January 2018

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Differential effects of selective HDAC inhibitors on macrophage inflammatory responses to the Toll-like receptor 4 agonist LPS.

21 January 2018

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Histone deacetylase inhibitors in inflammatory disease.

21 January 2018

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Granzyme A produces bioactive IL-1β through a nonapoptotic inflammasome-independent pathway.

21 January 2018

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An mRNA atlas of G protein-coupled receptor expression during primary human monocyte/macrophage differentiation and lipopolysaccharide-mediated activation identifies targetable candidate regulators of inflammation.

21 January 2018

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Preclinical anti-arthritic study and pharmacokinetic properties of a potent histone deacetylase inhibitor MPT0G009

21 January 2018

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Lysine acetylation in obesity, diabetes and metabolic disease.

21 January 2018

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Antifibrotic activity of an inhibitor of histone deacetylases in DOCA-salt hypertensive rats

21 January 2018

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Animal research: reporting in vivo experiments: the ARRIVE guidelines

21 January 2018

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The mechanism of osteoclast differentiation induced by IL-1.

21 January 2018

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Macrophages in rheumatoid arthritis

21 January 2018

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Use of the nitrile oxide cycloaddition (NOC) reaction for molecular probe generation: a new class of enzyme selective histone deacetylase inhibitors (HDACIs) showing picomolar activity at HDAC6.

21 January 2018

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HDAC inhibitors and immunotherapy; a double edged sword?

21 January 2018

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The histone deacetylase inhibitor ITF2357 reduces production of pro-inflammatory cytokines in vitro and systemic inflammation in vivo

21 January 2018

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The antitumor histone deacetylase inhibitor suberoylanilide hydroxamic acid exhibits antiinflammatory properties via suppression of cytokines

21 January 2018

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Managing macrophages in rheumatoid arthritis by reform or removal

21 January 2018

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Therapeutic effects of NK-HDAC-1, a novel histone deacetylase inhibitor, on collagen-induced arthritis through the induction of apoptosis of fibroblast-like synoviocytes.

21 January 2018

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Understanding local macrophage phenotypes in disease: shape-shifting macrophages

21 January 2018

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Anti-rheumatic activities of histone deacetylase (HDAC) inhibitors in vivo in collagen-induced arthritis in rodents.

21 January 2018

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An antagonist of human protease activated receptor-2 attenuates PAR2 signaling, macrophage activation, mast cell degranulation, and collagen-induced arthritis in rats

21 January 2018

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Histone deacetylases in skeletal development and bone mass maintenance

21 January 2018

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Drug insight: tumor necrosis factor-converting enzyme as a pharmaceutical target for rheumatoid arthritis

21 January 2018

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Protective and pathogenic functions of macrophage subsets

21 January 2018

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Trichostatin A, a histone deacetylase inhibitor, suppresses synovial inflammation and subsequent cartilage destruction in a collagen antibody-induced arthritis mouse model

21 January 2018

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Inflammasome-independent regulation of IL-1-family cytokines

21 January 2018

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Histone deacetylase inhibitors impair innate immune responses to Toll-like receptor agonists and to infection

21 January 2018

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Deacetylase inhibition increases regulatory T cell function and decreases incidence and severity of collagen-induced arthritis

21 January 2018

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Conservation and divergence in Toll-like receptor 4-regulated gene expression in primary human versus mouse macrophages

21 January 2018

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21 January 2018

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Histone deacetylase inhibitors promote osteoblast maturation

21 January 2018

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Inflammatory responses induced by lipopolysaccharide are amplified in primary human monocytes but suppressed in macrophages by complement protein C5a.

21 January 2018

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Histone deacetylases as regulators of inflammation and immunity

21 January 2018

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Clinical Toxicities of Histone Deacetylase Inhibitors

21 January 2018

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HDAC inhibitors: modulating leukocyte differentiation, survival, proliferation and inflammation.

21 January 2018

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Macrophage fusion: the making of osteoclasts and giant cells

21 January 2018

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HDAC inhibition in rheumatoid arthritis and juvenile idiopathic arthritis

21 January 2018

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Histone deacetylase inhibitor LAQ824 augments inflammatory responses in macrophages through transcriptional regulation of IL-10.

21 January 2018

1 reference

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New and emerging HDAC inhibitors for cancer treatment

21 January 2018

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The anticancer effects of HDAC inhibitors require the immune system

21 January 2018

1 reference

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DC-STAMP is essential for cell-cell fusion in osteoclasts and foreign body giant cells

21 January 2018

1 reference

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Macrophages from the synovium of active rheumatoid arthritis exhibit an activin A-dependent pro-inflammatory profile

21 January 2018

1 reference

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21 January 2018

Identifiers

DOI

10.1124/JPET.115.229328

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26660228%20AND%20SRC:MED&resulttype=core&format=json

2 March 2020

1 reference